Role of 5-HT receptor subtypes in the modulation of dorsal periaqueductal gray generated aversion

Nogueira, Ricardo de Carvalho; Graeff, Frederico Guilherme

doi:10.1016/0091-3057(94)00402-5

Cited by 114 publications

(70 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Whereas activation of 5-HT1A receptors hyperpolarizes the cell membrane, stimulation of 5-HT2A receptors excites it (Brandão et al 1991;Hoyer et al 2002). It has been suggested that the anti-escape effect resulting from the recruitment of 5-HT2A receptors is due to the activation of inhibitory GABAergic interneurons found in the dPAG (Nogueira and Graeff 1995). In support of this idea, immunocytochemical studies revealed that a high proportion of GABAergic neurons located in all regions of the PAG express 5-HT2A receptors (Griffts and Lovick 2002).…”

Section: Introductionmentioning

confidence: 88%

“…A previous study has shown that using a similar test protocol, there is no difference between animals tested 10 or 20 min after intra-dPAG injection of saline (Nogueira and Graeff 1995). Therefore, all control animals were tested 10 min after intra-dPAG injection of saline.…”

Section: Escape Threshold Determinationmentioning

confidence: 97%

“…It has been consistently shown that serotonin inhibits escape responses generated by electrical stimulation of the dPAG and that both 5-HT1A and 5HT2A receptors are implicated in this anti-aversive effect (de Bortoli et al 2006;Graeff 2004;Nogueira and Graeff 1995;Schutz et al 1985). Other evidence indicates that chronic treatment with antidepressant drugs such as fluoxetine and imipramine inhibits escape expression (Poltronieri et al 2003;Schenberg et al 2001;Teixeira et al 2000) and increases the reactivity of these two receptor subtypes in the dPAG (de Bortoli et al 2006;Jacob et al 2002).…”

Section: Introductionmentioning

confidence: 94%

“…Drug doses were based on previous studies carried out with the elevated T-maze and electrical stimulation of dPAG (Casarotto et al 2010;de Bortoli et al 2006;Nogueira and Graeff 1995;Schutz et al 1985;Zanoveli et al 2003Zanoveli et al , 2005Yamashita et al 2011). …”

Section: Escape Threshold Determinationmentioning

confidence: 99%

See 3 more Smart Citations

Serotonin-2A receptor regulation of panic-like behavior in the rat dorsal periaqueductal gray matter: the role of GABA

2011

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 88%

Section: Escape Threshold Determinationmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 94%

Section: Escape Threshold Determinationmentioning

confidence: 99%

See 2 more Smart Citations

Serotonin-2A receptor regulation of panic-like behavior in the rat dorsal periaqueductal gray matter: the role of GABA

2011

View full text Add to dashboard Cite

show abstract

“…Interestingly, Nogueira and Graeff showed that intra-PAG administration of the 5-HT1A receptor agonists (8-hydroxy-2-di-n-propylaminotetralin hydrobromide; 8-OH-DPAT and BAY-R-1532) decreased the escape threshold during PAG stimulation (Nogueira and Graeff, 1995). On the other hand, Jenck et al (1989), Beckett and Marsden (1997) showed the opposite effects with systemic injection of 5-OH-DPAT (Beckett andMarsden, 1997, Jenck, et al, 1989) in comparison with other neurochemical substances.…”

Section: Neurochemistry Of the Pag 41 Monoamines And Amino Acids 41mentioning

confidence: 99%

The Periaqueductal Gray: From Longitudinal columns to defensive behaviour

Lim¹,

Blokland²,

Wandevalle³

et al. 2009

jecm

View full text Add to dashboard Cite

Recent findings on the different functional properties of the neuroanatomical columnar subdivision of the Periaqueductal Gray (PAG) have provided a fundamental understanding for the pathophysiology of panic and anxiety disorder. In this review, we focus mainly on the prominent role of the PAG in defensive behaviour by combining both the behavioural and neuroanatomical data. We have applied the theoretical model of the "two dimensional defence system" by McNaughton and Corr (2004), and thereby constituted an organizational structure on the neuronal circuitry of the different brain regions in relation with this panic-and fearlike behaviour. It has become clear that the dorsal and lateral PAG are involved in the active emotional coping (fight and flight reaction), whereas the ventrolateral PAG is responsible for the passive emotional coping (quiescence/freezing). In this regard, the PAG and other related brain structures are working in concert with different neurotransmitters providing animals with defensive strategies in response to predatory threats. The functional roles of the PAG in these behaviours as characterized in animals warrants further translational studies in humans which may eventually lead to novel approaches in anxiety-and panic-related disorders.

show abstract