2020
DOI: 10.1038/s41598-020-73675-z
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Role of a genetic variation in the microRNA-4421 binding site of ERP29 regarding risk of oropharynx cancer and prognosis

Abstract: We conducted a two-stage association study on patients with oropharynx (OP) squamous cell carcinoma (SCC) and healthy controls to identify single nucleotide variants (SNVs) located at the microRNA (miR)-binding sites of carcinogenesis genes associated with risk and prognosis of the disease. In stage 1, 49 patients and 49 controls were analyzed using Genome-Wide Human SNV Arrays to identify variants in the 3′-untranslated region (3′-UTR) of carcinogenesis-related genes, and one SNV was selected for data validat… Show more

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Cited by 9 publications
(18 citation statements)
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References 48 publications
(78 reference statements)
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“…Initially, univariate Cox analysis with P < 0.001 was used to evaluate the relationship between DEGs and the survival time of HNSC patients [22]. To further narrow the scope of the candidate prognostic DEGs, we adopted the multivariate Cox regression and step backward Cox regression after primary filtration [23]. The linear combination of the regression coefficient (β) derived from the multivariate Cox regression model multiplied by its mRNA level generated a prognostic risk score with ten genes.…”
Section: Construction Of the Tp53-associated Prognostic Modelmentioning
confidence: 99%
“…Initially, univariate Cox analysis with P < 0.001 was used to evaluate the relationship between DEGs and the survival time of HNSC patients [22]. To further narrow the scope of the candidate prognostic DEGs, we adopted the multivariate Cox regression and step backward Cox regression after primary filtration [23]. The linear combination of the regression coefficient (β) derived from the multivariate Cox regression model multiplied by its mRNA level generated a prognostic risk score with ten genes.…”
Section: Construction Of the Tp53-associated Prognostic Modelmentioning
confidence: 99%
“…More details about the dataset of the cohort of OPSCC patients and the controls can be found in Carron et al [ 5 ]. The study was approved in keeping with the institutional review board guidelines (numbers: 424/2016 and 1,438,601) and according to the Declaration of Helsinki.…”
Section: Methodsmentioning
confidence: 99%
“…For survival analysis, we selected 139 patients; 13 out of 152 patients were sent to other services for treatment and follow-up, and no consistent clinical information could be retrieved. Patients were treated according to the institutional protocol, based on conventional procedures for CDDP, RT, and surgery [ 5 ]. The follow-up of patients was performed at 3-month intervals.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Besides having protective effect through inducing the expression of chaperones such as glucose regulatory proteins, ERS also induces endogenous apoptosis of cells independently by activating Bax to antagonize the protective effect of Bcl-2 [ 13 ], which also participates in pyroptosis by inhibiting the production of IL-1β [ 14 ]. Furthermore, ERp29 expression is upregulated under genotoxicity stress [ 15 18 ]. However, it remains largely unknown how the expression of ERp29 is regulated.…”
Section: Introductionmentioning
confidence: 99%