Role of a probiotic strain in the modulation of gut microbiota and cytokines in inflammatory bowel disease

Bamola, V Deepak; Dubey, Divya; Samanta, Projoyita; Kedia, Saurabh; Ahuja, Vineet; Madempudi, Ratna Sudha; Neelamraju, Jayanthi; Chaudhry, Rama

doi:10.1016/j.anaerobe.2022.102652

Cited by 17 publications

(6 citation statements)

References 65 publications

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“…Extensive success has been achieved in several cases of IBD (especially ulcerative colitis) (Akutko & Stawarski, 2021; Basso et al., 2019). But there are also some bacilli that have been shown to be protective against IBD (Bamola et al., 2022; Shinde et al., 2020). B. subtilis and B. coagulans , as examples, maintain the integrity of the intestinal mucosa and improve intestinal flora (Shinde et al., 2020; Zhang et al., 2021; Zhang, Li, et al., 2016).…”

Section: Application Status and Concernsmentioning

confidence: 99%

Probiotic characterization of Bacillus smithii: Research advances, concerns, and prospective trends

Zhao,

Huang,

Liu

et al. 2024

Comp Rev Food Sci Food Safe

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Bacillus smithii is a thermophilic Bacillus that can be isolated from white wine, hot spring soil, high‐temperature compost, and coffee grounds, with various biofunctions and wide applications. It is resistant to both gastric acid and high temperature, which makes it easier to perform probiotic effects than traditional commercial probiotics, so it can maintain good vitality during food processing and has great application prospects. This paper starts with the taxonomy and genetics and focuses on aspects, including genetic transformation, functional enzyme production, waste utilization, and application in the field of food science as a potential probiotic. According to available studies during the past 30 years, we considered that B. smithii is a novel class of microorganisms with a wide range of functional enzymes such as hydrolytic enzymes and hydrolases, as well as resistance to pathogenic bacteria. It is available in waste degradation, organic fertilizer production, the feed and chemical industries, the pharmaceutical sector, and food fortification. Moreover, B. smithii has great potentials for applications in the food industry, as it presents high resistance to the technological processes that guarantee its health benefits. It is also necessary to systematically evaluate the safety, flavor, and texture of B. smithii and explore its biological mechanism of action, which is of great value for further application in multiple fields, especially in food and medicine.

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Section: Application Status and Concernsmentioning

confidence: 99%

Probiotic characterization of Bacillus smithii: Research advances, concerns, and prospective trends

Zhao,

Huang,

Liu

et al. 2024

Comp Rev Food Sci Food Safe

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“…First, a series of in vitro experiments conducted on HT-29 cells demonstrated that treatment with Bifidobacteria strains led to reduced expression of inflammatory genes and lower cytokine production compared with untreated and pathogen-exposed cells [39 ▪ ]. Secondly, a RCT investigating Bacillus clausii UBBC-07 in 108 patients with IBD showed that supplementation with the probiotic led to increased abundances of putatively-beneficial bacteria (Bifidobacteria, Lactobacillus, Faecalibacterium ) compared with placebo in conjunction with increased secretion of IL-10 [40 ▪ ]. Translating the mechanistic rationale and experimental data to clinical evidence, however, has proven to be limited.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Probiotics in irritable bowel syndrome and inflammatory bowel disease: review of mechanisms and effectiveness

Quigley

Whelan

2023

Current Opinion in Gastroenterology

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Purpose of reviewThe gastrointestinal (GI) microbiome has been implicated in the pathogenesis of inflammatory bowel disease (IBD) and has been linked with irritable bowel syndrome (IBS). The aim of this article is to critically review the emerging evidence for the mechanisms and effectiveness of probiotics in the management of these conditions. Recent findingsThe GI microbiome is strongly influenced by ageing, diet and disease. Probiotics may confer health effects to the host by modulating the metabolic activities of the microbiome to propagate anti-inflammatory effects and reinforce the intestinal barrier, and are considered to be safe to use. Many short-term studies have demonstrated the effectiveness of probiotics overall in IBS, with meta-analyses demonstrating efficacy across specific strains albeit with relatively small effect sizes. Within IBD, some probiotics appear to offer clinical benefit in ulcerative colitis but strain-specific effects are unclear. Evidence for the use of probiotics in Crohn's disease remains limited.

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“…2,3 In the mucosa, they can produce a bactericidal effect, restore the imbalanced intestinal microbiota, inactivate toxins, and improve the response of the immune system by stimulating the complement and IgA fractions and reducing the inflammatory process. 2,3 In addition, they may reduce carbohydrate absorption through the efficient removal of carbohydrates from the intestinal lumen through short-chain fatty acids production. 4 Clinical trials have documented the potential of probiotics in the prevention and/or treatment of infectious diseases, particularly gastrointestinal (GI) and urogenital conditions.…”

mentioning

confidence: 99%

“…Probiotics are believed to ferment nonabsorbable substrates in the intestinal lumen and thus modulate gases, favor the conjugation of bile salts, act in the acidification of short-chain fatty acids, and increase intestinal transit 2,3. In the mucosa, they can produce a bactericidal effect, restore the imbalanced intestinal microbiota, inactivate toxins, and improve the response of the immune system by stimulating the complement and IgA fractions and reducing the inflammatory process 2,3. In addition, they may reduce carbohydrate absorption through the efficient removal of carbohydrates from the intestinal lumen through short-chain fatty acids production 4…”

mentioning

confidence: 99%

“…4 Clinical trials have documented the potential of probiotics in the prevention and/or treatment of infectious diseases, particularly gastrointestinal (GI) and urogenital conditions. 2,3,5 The effect of probiotics in colorectal cancer has shown positive effects in treated patients, resulting in benefits such as decreased enterobacteria and enterococci, improvement in the modulation of local immunity, improvement of GI symptoms, and recovery of intestinal function, among others. 6 Antibiotics are medications prescribed for numerous infectious diseases.…”

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confidence: 99%

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Probiotics in the Management of Antibiotic-Associated Diarrhea in Children

Fadin,

Vieira,

Toledo

et al. 2023

Topics in Clinical Nutrition

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This review aimed to evaluate probiotic use to prevent antibiotic-associated diarrhea in children. A total of 1564 studies of randomized clinical trials published in English were found using PubMed, Cochrane, and Virtual Health Library (MEDLINE/LILACS). A meta-analysis included 4 trials in subgroup Lactobacillus rhamnosus (95% confidence interval [CI]: 0.17-0.49; P < .00001), 2 trials in subgroup L reuteri (95% CI: 0.51-1.77; P = .87), and 5 groups in subgroup association of species of probiotics (95% CI: 0.21-1.71; P = .33). The findings suggest that L rhamnosus alone may be useful in preventing antibiotic-associated diarrhea in children.

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Role of a probiotic strain in the modulation of gut microbiota and cytokines in inflammatory bowel disease

Cited by 17 publications

References 65 publications

Probiotic characterization of Bacillus smithii: Research advances, concerns, and prospective trends

Probiotic characterization of Bacillus smithii: Research advances, concerns, and prospective trends

Probiotics in irritable bowel syndrome and inflammatory bowel disease: review of mechanisms and effectiveness

Probiotics in the Management of Antibiotic-Associated Diarrhea in Children

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