2022
DOI: 10.3390/jpm12061010
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Role of ABCA1 in Cardiovascular Disease

Abstract: Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most important proteins that maintains cholesterol homeostasis. ABCA1 mediates nascent high-density lipoprotein biogenesis. Upon binding with apolipoprotein A-I, ABCA1 facilitates the efflux of excess intracellular cholesterol and phospholipids and controls the rate-limiting step of reverse cholesterol transport. In addition, ABCA1 interacts … Show more

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Cited by 32 publications
(22 citation statements)
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“…PCSK9 has been reported to inhibit the LDL receptor, resulting in lower cholesterol uptake by the liver and subsequent higher cholesterol concentrations in the circulation [ 38 ]. Intestinal ABCA1 promotes the efflux of free cholesterol from cells to HDL, which contributes to reverse cholesterol transport [ 39 ]. Based on our data, NR supplementation resulted in the lower mRNA expression of hepatic PCSK9 and higher mRNA expression of intestinal ABCA1 in ApoE -/- mice fed with HFD than mice without supplementation.…”
Section: Discussionmentioning
confidence: 99%
“…PCSK9 has been reported to inhibit the LDL receptor, resulting in lower cholesterol uptake by the liver and subsequent higher cholesterol concentrations in the circulation [ 38 ]. Intestinal ABCA1 promotes the efflux of free cholesterol from cells to HDL, which contributes to reverse cholesterol transport [ 39 ]. Based on our data, NR supplementation resulted in the lower mRNA expression of hepatic PCSK9 and higher mRNA expression of intestinal ABCA1 in ApoE -/- mice fed with HFD than mice without supplementation.…”
Section: Discussionmentioning
confidence: 99%
“…We report the case of a patient referred to our clinic presenting features typical of Tangier disease with a likely pathogenic ABCA1 variant, c.4799A>G, identified for the first time as homozygous. Several types of variants in ABCA1 have been identified, with missense and frameshift variants being the most often described [ 32 ]. In ClinVar, there are 37 likely pathogenic/pathogenic variants in ABCA1, of which 14 are associated with TD.…”
Section: Discussionmentioning
confidence: 99%
“…PCSK9 is a key protein in LDL metabolism and helps in the degradation of LDL receptors 26 . ABCA1 is an important protein for maintaining cholesterol homeostasis, promoting intracellular excess cholesterol and phospholipid efflux, and controlling the rate‐limiting step of the reverse cholesterol transport mechanism 27 . APOa1 is the major plasma HDL lipoprotein that exhibits several proven cardioprotective functions 28 .…”
Section: Discussionmentioning
confidence: 99%