Role of ACE, ACE2 and Neprilysin in the Kidney

Chappell, Mark C.

doi:10.1007/978-1-4020-6372-5_1

Cited by 2 publications

(2 citation statements)

References 121 publications

(140 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another pathway of Ang II degradation involves digestion by neprilysin, endopeptidases, and carboxypeptidases into small peptide fragments of unknown biological function (Figure 1). 11,12 There is overwhelming evidence that renin is the ratelimiting step in the activation of Ang II via its control of Ang I formation. 13 For instance, changes in salt intake modulate Ang II activity largely via changes in renin release and circulating plasma renin activity.…”

Section: Ace2 and The Ang II Degrading Pathwaymentioning

confidence: 99%

Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy

Batlle

Wysocki

Soler

et al. 2012

Kidney International

115

110

View full text Add to dashboard Cite

Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that degrades angiotensin II with high efficiency leading to the formation of angiotensin-(1-7). ACE2 within the kidneys is largely localized in tubular epithelial cells and in glomerular epithelial cells. Decreased glomerular expression of this enzyme coupled with increased expression of ACE has been described in diabetic kidney disease, both in mice and humans with type 2 diabetes. Moreover, both ACE2 genetic ablation and pharmacological ACE2 inhibition have been shown to increase albuminuria and promote glomerular injury. Studies using recombinant ACE2 have shown the ability of ACE2 to rapidly metabolize Ang II in vivo and form the basis for future studies to examine the potential of ACE2 amplification in the therapy of diabetic kidney disease and cardiovascular disease.

show abstract

Section: Ace2 and The Ang II Degrading Pathwaymentioning

confidence: 99%

Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy

Batlle

Wysocki

Soler

et al. 2012

Kidney International

115

110

View full text Add to dashboard Cite

show abstract

“…ACE2 exhibits the highest efficiency constant among the enzymes capable of forming Ang-(1–7) from the substrates Ang I, Ang II or Ang-(1–9). The efficiency constant is the ratio of the catalytic (kcat) constant to the Michelis-Menten (Km) value for prolyl (oligo) endopeptidase (PO), neprilysin (NP), angiotensin converting enzyme 2 (ACE2), ACE and prolyl carboxypeptidase (PC) 20.…”

Section: Figuresmentioning

confidence: 99%

Does ACE2 contribute to the development of hypertension?

Chappell

2009

Hypertens Res

View full text Add to dashboard Cite

Role of ACE, ACE2 and Neprilysin in the Kidney

Cited by 2 publications

References 121 publications

Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy

Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy

Does ACE2 contribute to the development of hypertension?

Contact Info

Product

Resources

About