Role of acidic pH of intravenous fluids in subsequent development of metabolic acidosis- may not be what it seems

Acute kidney injury (AKI) is a complex and life-threatening condition with multifactorial etiologies, ranging from ischemic injury to nephrotoxic exposures. Management is founded on treating the underlying cause of AKI, but supportive care—via fluid management, vasopressor therapy, kidney replacement therapy (KRT), and more—is also crucial. Blood pressure targets are often higher in AKI, and these can be achieved with fluids and vasopressors, some of which may be more kidney-protective than others. Initiation of KRT is controversial, and studies have not consistently demonstrated any benefit to early start dialysis. There are no targeted pharmacotherapies for AKI itself, but some do exist for complications of AKI; additionally, medications become a key aspect of AKI management because changes in renal function and dialysis support can lead to issues with both toxicities and underdosing. This review will cover existing literature on these and other aspects of AKI treatment. Additionally, this review aims to identify gaps and challenges and to offer recommendations for future research and clinical practice.

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Role of acidic pH of intravenous fluids in subsequent development of metabolic acidosis- may not be what it seems

Cited by 3 publications

References 5 publications

A Novel Approach for the Measurement of pH of Body Fluids at Various Temperatures Using Compensation Technique

A Novel Approach for the Measurement of pH of Body Fluids at Various Temperatures Using Compensation Technique

Dissolution of Polysorbate 20 Degradation Related Free Fatty Acid Particles in Intravenous Bag Solutions

Treatment of Acute Kidney Injury: A Review of Current Approaches and Emerging Innovations

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