Role of activated macrophages in experimental Fusarium solani keratitis

Cytoarchitecture of epithelial inflammatory infiltration indicates the aetiology of infectious keratitis

“…Additionally, fungal keratitis involved four of five of described cell types, while in viral and bacterial keratitis, only two of five types were present. According to the literature, the polymorphous round cells observed in fungal keratitis might represent neutrophils and specific subtypes of T cells, while the dendriform cells might represent different subtypes of antigen-presenting cells and stimulated macrophages (Hu et al 2014). The IVCM features of Candida keratitis demonstrated fungal colonization of the corneal epithelium that was associated with a reduced adhesion of the epithelial cells, as reported by other authors (Hostetter 1994).…”

“…Mycological cultures grow slowly and give a positive answer in only 50-60% of cases (Nielsen et al 2013). According to the literature, the polymorphous round cells observed in fungal keratitis might represent neutrophils and specific subtypes of T cells, while the dendriform cells might represent different subtypes of antigen-presenting cells and stimulated macrophages (Hu et al 2014). It includes several types of both resident and infiltrating inflammatory cells (Leal & Pearlman 2012).…”

Moxifloxacin Modulated TGF-β1-Related Interleukin-12 Secretion in Corneal Fibroblasts

“…IL-12 is involved in antigen presentation and corneal inflammation. [13][14][15] As IL-12 is also FIGURE 7. Effect of conditioned medium from IL-12-silenced HCFs on cell migration.…”

“…This echoes the reports that the tear concentration of IL-12 is low but with great variability. 12,26 It increases following surgery 15 and in the cornea of infectious keratitis 13,14 since there is a TGF-b1 surge following corneal wounding 27 and/or infection. 28 Our results indicate an interindividual variation in the production and TGF-b1 regulation of IL-12 in noninflammatory cell; that is, corneal fibroblast.…”

“…In the eye, IL-12 is present in the tear at 89.8 6 115.8 pg/ mL. 12 Its expression increased significantly in the corneas with fungal 13 and herpetic stromal keratitis. 14 It also increased in the tears of patients following refractive surgery.…”