Role of active and passive smoking on lung cancer etiology in Mexico City

Franco‐Marina, Francisco; Caloca, Jaime Villalba; Corcho-Berdugo, Alexánder

doi:10.1590/s0036-36342006000700009

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…54,55 Higher lung cancer mortality rates were observed in the northern region with women experiencing higher mortality in the central states of Mexico, 56,57 although trends are predicted to increase in the southern and poorer regions of the country. 58 The decreasing mortality rates in the central regions surrounding Mexico City suggest that access to early detection programs, state of the art treatment and specialized medical services increases survival of cancer patients.…”

Section: Discussionmentioning

confidence: 99%

The burden of cancer in Mexico, 1990-2013

et al. 2016

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Objective. To analyze mortality and incidence for 28 cancers by deprivation status, age and sex from 1990 to 2013. Materials and methods. The data and methodological approaches provided by the Global Burden of Disease (GBD 2013) were used. Results. Trends from 1990 to 2013 show important changes in cancer epidemiology in Mexico. While some cancers show a decreasing trend in incidence and mortality (lung, cervical) others emerge as relevant health priorities (prostate, breast, stomach, colorectal and liver cancer). Age standardized incidence and mortality rates for all cancers are higher in the northern states while the central states show a decreasing trend in the mortality rate. The analysis show that infection related cancers like cervical or liver cancer play a bigger role in more deprived states and that cancers with risk factors related to lifestyle like colorectal cancer are more common in less marginalized states. Conclusions. The burden of cancer in Mexico shows complex regional patterns by age, sex, types of cancer and deprivation status. Creation of a national cancer registry is crucial.Keywords: cancer; burden of disease; mortality; incidence; social condition; cause of death; epidemiology ResumenObjetivo. Analizar la incidencia y la mortalidad de 28 tipos de cáncer por nivel de marginación, grupos de edad y sexo, de 1990 a 2013. Material y métodos. Los datos utilizados provienen del estudio de la Carga Global de Enfermedades (2013). Las entidades federativas se clasificaron de acuerdo con el índice de marginación del Consejo Nacional de Población. Resultados. Los datos muestran una tendencia decreciente para algunos cánceres (pulmón y cervical), mientras otros aparecen como prioritarios y relevantes (próstata, mama, estómago, colon e hígado). En el norte se observan incrementos regionales mayores en las tasas de incidencia y mortalidad estandarizadas por edad, mientras que en los estados del centro se observa una tendencia decreciente de la tasa de mortalidad. Conclusiones. La epidemiología del cáncer en México (en su mayoría basada en datos de mortalidad) presentan patrones regionales complejos por edad, sexo, tipo de cáncer e índice de marginación. Es vital la creación de un registro nacional para mejorar el seguimiento y evaluación de intervenciones preventivas y curativas.

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Section: Discussionmentioning

confidence: 99%

The burden of cancer in Mexico, 1990-2013

et al. 2016

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“…It is well known that there is a significant dose-response association between smoking and the risk of lung cancer (Jockel et al, 1998;Franco-Marina et al, 2006;Neuberger et al, 2006). Thus, we wanted to evaluate whether the smoking history can influence the association between genetic polymorphism of MCP-1 and NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Relationship between genetic polymorphism of MCP-1 and non-small-cell lung cancer in the Han nationality of North China

Yang¹,

Shi²,

Song³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. Monocyte chemoattractant protein 1 (MCP-1) is an important chemokine that has a dose-dependent anti-tumoral effect. Polymorphism in the MCP-1 distal regulatory region (-2518A/G) can affect the level of MCP-1 expression. We examined the polymorphisms of 112 unrelated patients with non-small-cell lung cancer (NSCLC) and 82 unrelated healthy controls of Han nationality in North China using PCR-RFLP. We found that the distributions of AA, AG and GG genotypes of MCP-1-2518 were significantly different in NSCLC patients compared to controls (χ 2 = 10.106, P = 0.006). There was a significant increase in the frequency of the AA genotype (odds ratio (OR) = 3.138, χ 2 = 8.905, P = 0.003) and a significant decrease in the frequency of the GG genotype (OR = 0.516, χ 2 = 4.613, P = 0.032) in the NSCLC patients, compared to controls. The frequencies of AA, AG and GG genotypes did not differ in the NSCLC patients according to the number of pack-years smoked. Based on these results, we suggest that the MCP-1 -2518A/G polymorphism is associated with genetic susceptibility to NSCLC.

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“…It is well known that tobacco smoking is the leading cause of LC [21][22][23]; every risk model used for estimating the risk of radon-induced LC must take into account this fact.…”

Section: Methodsmentioning

confidence: 99%

Study of epidemiological risk of lung cancer in Mexico due indoor radon exposure

Angeles¹,

Espinosa²

2014

AIP Conference Proceedings

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Abstract. In this work the lifetime relative risks (LRR) of lung cancer due to exposure to indoor 222 Rn on the Mexican population is calculated. Cigarette smoking is the number one risk factor for lung cancer (LC), because that, to calculate the number of cases of LC due to exposure to 222 Rn is necessary considers the number of cases of LC for smoking cigarette. The lung cancer mortality rates published by the "Secretaría de Salud" (SSA), the mexican population data published by the "Consejo Nacional de Población" (CONAPO), smoking data in the mexican population, published by the "Comisión Nacional Contra las Adicciones" (CONADIC), the "Organización Panamericana de la Salud" (OPS) and indoor 222 Rn concentrations in Mexico published in several recent studies are used. To calculate the lifetime relative risks (LRR) for different segments of the Mexican population, firstly the Excess Relative Risk (ERR) is calculated using the method developed by the BEIR VI committee and subsequently modified by the USEPA and published in the report "EPA Assessment of Risks from Radon in Homes". The excess relative risks were then used to calculate the corresponding lifetime relative risks, again using the method developed by the BEIR VI committee. The lifetime relative risks for Mexican male and female eversmokers and Mexican male and female never-smokers were calculated for radon concentrations spanning the range found in recent studies of indoor radon concentrations in Mexico. The lifetime relative risks of lung cancer induced by lifetime exposure to the mexican average indoor radon concentration were estimated to be 1.44 and 1.40 for never-smokers mexican females and males respectively, and 1.19 and 1.17 for ever-smokers Mexican females and males respectively. The Mexican population LRR values obtained in relation to the USA and Canada LRR published values in ever-smokers for both gender are similar with differences less than 4 %, in case of never-smokers in relation with Canada population the differences in LRR values are less than 2% and in never-smokers for the USA population the differences in LRR values compared with the Mexican population are about 10%.

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Role of active and passive smoking on lung cancer etiology in Mexico City

Cited by 8 publications

References 32 publications

The burden of cancer in Mexico, 1990-2013

The burden of cancer in Mexico, 1990-2013

Relationship between genetic polymorphism of MCP-1 and non-small-cell lung cancer in the Han nationality of North China

Study of epidemiological risk of lung cancer in Mexico due indoor radon exposure

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