Role of acute infection in triggering acute coronary syndromes

Corrales–Medina, Vicente F.; Madjid, Mohammad; Musher, Daniel M.

doi:10.1016/s1473-3099(09)70331-7

Cited by 415 publications

(376 citation statements)

References 110 publications

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“…Corrales-Medina et al, reported hospitalisation for pneumonia was associated with increased short-term and long-term risk of CVD and development of acute coronary syndromes [25,27,28].…”

Section: Cardiovascular Stress and Morbidity In Elderly Cap Patientsmentioning

confidence: 99%

Macrolides: Are They Safe Bet in Management of Community Acquired Pneumonia (CAP) in Elderly Patients Admitted to an Intensive Care Unit (ICU)

Inzirillo¹,

Giorgetta²,

Ravalli³

et al. 2017

Insights Chest Dis

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“…Corrales-Medina et al, reported hospitalisation for pneumonia was associated with increased short-term and long-term risk of CVD and development of acute coronary syndromes [25,27,28].…”

Section: Cardiovascular Stress and Morbidity In Elderly Cap Patientsmentioning

confidence: 99%

Macrolides: Are They Safe Bet in Management of Community Acquired Pneumonia (CAP) in Elderly Patients Admitted to an Intensive Care Unit (ICU)

Inzirillo¹,

Giorgetta²,

Ravalli³

et al. 2017

Insights Chest Dis

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“…Pneumonia not only results in hospital admissions of the elderly, but also results in a significant cost to primary care [7]. There is also evidence that the influenza vaccination prevents the acute myocardial infarction, with infection being a likely trigger for the acute thrombosis in underlying diseased arteries [8][9][10]. It has also been shown that 10% of AMI patients have undiagnosed influenza, and patients at risk of heart disease are under-vaccinated [8].…”

Section: Ageing and Prevention Of Infectionmentioning

confidence: 99%

Elderly vaccination—The glass is half full

MacIntyre¹

2013

Health

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The shifting global demography and ageing of populations worldwide brings with new challenges for the health care, and an imperative for healthy ageing and preventive health strategies for adults. Immunization is the low hanging fruit for healthy ageing, and yet under-utilized for various reasons, including waning immunity in the elderly, lack of RCT data in this age group, and lack of provider confidence in vaccines for the elderly. The elderly people have a higher incidence of infection and more severe and serious consequences of infection. Diseases such as influenza, pneumococcal disease and herpes zoster have long been recognized as causing a high burden in the elderly, but evidence is also emerging for other infections such as pertussis being a major cause of the morbidity in this age group. Now, there are several vaccines which can prevent major infectious diseases in the elderly. To improve uptake of these vaccines, elderly vaccination should be viewed through a different lens to pediatric vaccination, accepting that vaccines are less immunogenic in the elderly. The population health impact of vaccines in the elderly, despite of immunosenescence and lower immunogenicity, is still likely to be high given the increased disease incidence. Vaccination is an important and readily available means of prevention in the elderly.

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“…The majority of patients with CAP have coexisting cardiac disease [11]. Infections such as CAP cause a surge of inflammatory mediators and prothrombogenic milieu, resulting in instability of the coronary plaques, biomechanical stress from the interplay of vascular volume and tone, and increased load from high metabolic demand [12]. In a prospective 30-day study of 1,343 inpatients and 944 outpatients with CAP, 26.7 % of inpatients and 2.1 % of outpatients had cardiac events, with the majority occurring within the first week, and more than half occurring within the first 24 hours.…”

Section: Cap and Other Diseasesmentioning

confidence: 99%

Management of community-acquired pneumonia

Ehsan¹,

Metersky

2013

Curr Respir Care Rep

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This article summarizes recent literature related to community-acquired pneumonia (CAP), which continues to represent one of the most common causes of morbidity and mortality throughout the world, especially in the elderly. The impact is even more striking if we take healthcare costs into account. Patients with CAP usually have other comorbidities which not only increase mortality in this group but also add further to its economic burden. Patients with COPD, preexisting cardiac disease, and diabetes are particularly at higher risk for developing more severe pneumonia. New diagnostic modalities, including ultrasonography, are being used more commonly in clinical practice. Procalcitonin levels can be used to identify bacterial pneumonia and to de-escalate antibiotic therapy, resulting in fewer days on antibiotics. Other biomarkers have been used in studies to stratify patients by risk. Guideline-concordant regimens including atypical coverage, and macrolides in particular, appear to provide benefit. More recent data suggest the need for careful screening of patients for cardiovascular risk factors prior to initiating macrolides and fluoroquinolones.

show abstract

Role of acute infection in triggering acute coronary syndromes

Cited by 415 publications

References 110 publications

Macrolides: Are They Safe Bet in Management of Community Acquired Pneumonia (CAP) in Elderly Patients Admitted to an Intensive Care Unit (ICU)

Macrolides: Are They Safe Bet in Management of Community Acquired Pneumonia (CAP) in Elderly Patients Admitted to an Intensive Care Unit (ICU)

Elderly vaccination—The glass is half full

Management of community-acquired pneumonia

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