Role of additives and solvents in the synthesis of chiral isoreticular MOF-74 topologies

Gheorghe, Anca; Reus, Suzanne; Koenis, Mark A. J.; Dubbeldam, David; Woutersen, Sander; Tanase, Stéfania

doi:10.1039/d1dt01945g

Cited by 7 publications

(2 citation statements)

References 42 publications

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“…These factors can affect the final structures of crystalline materials. The importance of the solvent role relies on its template effect in the crystallization process. − It has been shown that different MOFs can be achieved from the same ingredients by changing the kinds of solvents. , The solvent molecules can play their roles in the reactions by providing a reaction medium, coordinating to metal ions, and inhabitation in the voids of porous materials . Solvent molecules can coordinate with metal ions during the preparation of MOFs, which could affect the final structure by their structure-directing properties .…”

Section: Resultsmentioning

confidence: 99%

Design of Calcium-Based Metal–Organic Frameworks by the Solvent Effect and Computational Investigation of Their Potential as Drug Carriers

Alavijeh

Akhbari

Bernini

et al. 2022

Crystal Growth & Design

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In this study, a new Ca-based metal−organic framework (MOF) was designed by the solvent effect. In fact, one known and one new Ca-based MOF with different structures were obtained by changing one reaction parameter (solvent). The structures of [Ca(BDC)(DMF)-(H 2 O)] n (1) and [Ca(HBDC)(BDC) 0.5 (DMA) 2 ] n (MUT-3) were compared to test the effect of solvent (DMF = dimethylformamide or DMA = dimethylacetamide) on the architectures of the resulting frameworks. Both compounds were computationally characterized by means of Monte Carlo simulations to obtain their void fractions, accessible surface areas, pore size distributions, and pore volumes.Additionally, grand canonical Monte Carlo simulations were performed to determine the potential of both MOFs as likely drug carriers for 5-fluorouracil (5-FU) as an anticancer drug. Adsorption isotherms, snapshots, the energy of adsorption, and radial distribution functions were calculated. The obtained results showed higher pore volume and accessible surface area and amount of 5-FU loading for MUT-3 compared to compound 1.

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Section: Resultsmentioning

confidence: 99%

Design of Calcium-Based Metal–Organic Frameworks by the Solvent Effect and Computational Investigation of Their Potential as Drug Carriers

Alavijeh

Akhbari

Bernini

et al. 2022

Crystal Growth & Design

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“…iii) The third approach is an indirect method that leads to the formation of achiral frameworks and utilization of some external chiral agents to produce stereogenic centres ( Xue et al, 2016 ; Zavakhina et al, 2019 ). Chiral inducing compounds may involve chiral guest, solvent, auxiliary pendant or functionalization ( Gheorghe et al, 2021 ). In this last case the presence of an enantiopure chiral agent is the driving force that induces chirality.…”

Section: Introductionmentioning

confidence: 99%

Chiral “doped” MOFs: an electrochemical and theoretical integrated study

Kawondera,

Bonechi,

Maccioni

et al. 2023

Front. Chem.

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This work reports on the electrochemical behaviour of Fe and Zn based metal-organic framework (MOF) compounds, which are “doped” with chiral molecules, namely: cysteine and camphor sulfonic acid. Their electrochemical behaviour was thoroughly investigated via “solid-state” electrochemical measurements, exploiting an “ad hoc” tailored experimental set-up: a paste obtained by carefully mixing the MOF with graphite powder is deposited on a glassy carbon (GC) surface. The latter serves as the working electrode (WE) in cyclic voltammetry (CV) measurements. Infrared (IR), X-ray diffraction (XRD) and absorbance (UV-Vis) techniques are exploited for a further characterization of the MOFs’ structural and electronic properties. The experimental results are then compared with DFT based quantum mechanical calculations. The electronic and structural properties of the MOFs synthesized in this study depend mainly on the type of metal center, and to a minor extent on the chemical nature of the dopant.

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Tunable Zn-MOF-74 nanocarriers coated with sodium alginate as versatile drug carriers

Kazemi,

Afshari,

Baesmat

et al. 2024

Polym. Bull.

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Role of additives and solvents in the synthesis of chiral isoreticular MOF-74 topologies

Abstract: Chiral induction is a simple and inexpensive approach to synthesise chiral metal-organic frameworks, even when using achiral building-blocks. The challenge lies in selecting the proper chiral inductor. This can only...

Cited by 7 publications

References 42 publications

Design of Calcium-Based Metal–Organic Frameworks by the Solvent Effect and Computational Investigation of Their Potential as Drug Carriers

Design of Calcium-Based Metal–Organic Frameworks by the Solvent Effect and Computational Investigation of Their Potential as Drug Carriers

Chiral “doped” MOFs: an electrochemical and theoretical integrated study

Tunable Zn-MOF-74 nanocarriers coated with sodium alginate as versatile drug carriers

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