Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease

Ma, Lele; Lu, Zuneng

doi:10.4238/gmr.15048740

Cited by 21 publications

(17 citation statements)

References 30 publications

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“…The accumulative analysis presented fluctuating findings and the results tending to show a potential association by Ma et al (29) (Figure 3 for A vs. G model, Supplementary Figure S2 for other models). A sensitivity analysis was conducted by removing each included study, and fluctuating results were observed after several studies were removed (Figure 4 for A vs. G model, Supplementary Figure S3 for other models).…”

Section: Resultsmentioning

confidence: 87%

“…Finally, nine publications (11 independent studies) involving 2,283 patients and 3,032 controls were included (15, 23–30). Three common SNPs were reported; eight studies focused on the rs671 G>A polymorphism (15, 23–29), two studies focused on the rs4767944 C>T polymorphism (27, 30), and one study focused on the rs441 T>C polymorphism (27). In all included studies, most subjects were from East Asians countries including China, Japan, and Korea, except for one study that was performed in the Iranian population (30).…”

Section: Resultsmentioning

confidence: 99%

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Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals

et al. 2019

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Objective: A number of studies have reported that aldehyde dehydrogenase-2 ( ALDH2 ) polymorphisms maybe associated with the risk of Alzheimer's disease (AD) and Parkinson's disease (PD). However, the results of such studies are inconsistent. We therefore conducted a meta-analysis to clarify the association between ALDH2 polymorphisms and the risk of AD and PD. Methods: Five online databases were searched and the relevant studies were reviewed from inception through May 10, 2018. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated in each genetic model of the general population and various subgroups. Furthermore, we simultaneously performed heterogeneity, cumulative, sensitivity, and publication bias analyses. Results: Overall, nine case-control studies involving 5,315 subjects were included in this meta-analysis. Potential associations were found between the ALDH2 rs671 G>A polymorphism and the risk of AD (A vs. G: OR = 1.46, 95%CI = 1.01–2.11, P = 0.05, I 2 = 84.2%; AA vs. GG: OR = 2.22, 95%CI = 1.03–4.77, P = 0.04, I 2 = 79.2%; AA vs. GG+GA: OR = 1.94, 95%CI = 1.03–3.64, P =0.04, I 2 = 71.1%). In addition, some similar results were observed in other subgroups. Moreover, no significant association between ALDH2 polymorphisms and PD risk. Conclusions: In conclusion, our meta-analysis indicated that the ALDH2 rs671 G>A polymorphism plays an important role in AD development.

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Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals

et al. 2019

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“…Several reports of genetic modifications, such as genome-wide association studies (GWAS) and single genetic association studies, have reported gene variation on ALDH2 in East Asian patients (Hao et al, 2011). In this respect, Ma et al (2016) investigated the association between ADH1B rs1229984 and ALDH2 rs671…”

Section: Molecular Alterationsmentioning

confidence: 99%

Aldehyde dehydrogenase 2 in the spotlight: The link between mitochondria and neurodegeneration

et al. 2018

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Growing body of evidence suggests that mitochondrial dysfunctions and resultant oxidative stress are likely responsible for many neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Aldehyde dehydrogenase (ALDH) superfamily plays a crucial role in several biological processes including development and detoxification pathways in the organism. In particular, ALDH2 is crucial in the oxidative metabolism of toxic aldehydes in the brain, such as catecholaminergic metabolites (DOPAL and DOPEGAL) and the principal product of lipid peroxidation process 4-HNE. This review aims to deepen the current knowledge regarding to ALDH2 function and its relation with brain-damaging processes that increase the risk to develop neurodegenerative disorders. We focused on relevant literature of what is currently known at molecular and cellular levels in experimental models of these pathologies. The understanding of ALDH2 contributions could be a potential target in new therapeutic approaches for PD and AD due to its crucial role in mitochondrial normal function maintenance that protects against neurotoxicity.

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“…However, the actual mechanisms are unknown. The ALDH2 polymorphisms are related to Alzheimer's disease, which implies an association between ALDH2 polymorphisms and memory function [17,18].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, ALDH2 polymorphisms are associated with the effects of alcohol on various neurophysiological and psychomotor functions [19,20]. All these studies [17][18][19][20] hypothesized that the ALDH2 gene polymorphisms affect aldehyde metabolism and cognitive function. We therefore hypothesize that the ALDH2 gene affects the cognitive functions in patients with OUD as it does in alcohol abusers, and that it leads to the underlying cognitive deficits in OUD.…”

Section: Introductionmentioning

confidence: 99%

ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment

Lee

Wang

Chang

et al. 2020

Clin Psychopharmacol Neurosci

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Objective: Patients with opioid use disorder (OUD) have impaired attention, inhibition control, and memory function. The aldehyde dehydrogenase 2 (ALDH2) gene has been associated with OUD and ALDH2 gene polymorphisms may affect aldehyde metabolism and cognitive function in other substance use disorder. Therefore, we aimed to investigate whether ALDH2 genotypes have significant effects on neuropsychological functions in OUD patients undergoing methadone maintenance therapy (MMT). Methods: OUD patients undergoing MMT were investigated and followed-up for 12 weeks. ALDH2 gene polymorphisms were genotyped. Connors' Continuous Performance Test (CPT) and the Wechsler Memory Scale-Revised (WMS-R) were administered at baseline and after 12 weeks of MMT. Multivariate linear regressions and generalized estimating equations (GEEs) were used to examine the correlation between the ALDH2 genotypes and performance on the CPTs and WMS-R. Results: We enrolled 86 patients at baseline; 61 patients completed the end-of-study assessments. The GEE analysis showed that, after the 12 weeks of MMT, OUD patients with the ALDH2 *1/*2＋*2/*2 (ALDH2 inactive) genotypes had significantly higher commission error T-scores (p = 0.03), significantly lower hit reaction time T-scores (p = 0.04), and significantly lower WMS-R visual memory index scores (p = 0.03) than did patients with the ALDH2 1*/*1 (ALDH2 active) genotype. Conclusion: OUD patients with the ALDH2 inactive genotypes performed worse in cognitive domains of attention, impulse control, and memory than did those with the ALDH2 active genotype. We conclude that the ALDH2 gene is important in OUD and is associated with neuropsychological performance after MMT.

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Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease

Cited by 21 publications

References 30 publications

Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals

Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals

Aldehyde dehydrogenase 2 in the spotlight: The link between mitochondria and neurodegeneration

ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment

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