Role of adipose tissue in regulating fetal growth in gestational diabetes mellitus

Nguyen-Ngo, Caitlyn; Jayabalan, Nanthini; Haghvirdizadeh, Polin; Salomón, Carlos; Lappas, Martha

doi:10.1016/j.placenta.2020.05.006

Cited by 11 publications

(9 citation statements)

References 175 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Insulin resistance is involved in the development of GDM. Adipose tissue plays a major role in the development of insulin resistance during pregnancy [ 123 , 124 ], and adipose tissue-derived exosomes have been shown to affect biological processes such as metabolism, inflammation, regulation of glucose homeostasis, and insulin sensitivity [ 125 ]. A study [ 23 ] analyzed and compared the protein expression of exosomes from adipose tissue.…”

Section: The Possible Mechanism Of Exosomes Participation In Gdmmentioning

confidence: 99%

The Mystery of Exosomes in Gestational Diabetes Mellitus

Chen

Liu

2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) is one of the common pregnancy complications, which increases the risk of short-term and long-term adverse consequences in both the mother and offspring. However, the pathophysiological mechanism of GDM is still poorly understood. Inflammation, insulin resistance and oxidative stress are considered critical factors in the occurrence and development of GDM. Although the lifestyle intervention and insulin are the primary treatment, adverse pregnancy outcomes still cannot be ignored. Exosomes have a specific function of carrying biological information, which can transmit information to target cells and play an essential role in intercellular communication. Their possible roles in normal pregnancy and GDM have been widely concerned. The possibility of exosomal cargos as biomarkers of GDM is proposed. This paper reviews the literature in recent years and discusses the role of exosomes in GDM and their possible mechanisms to provide some reference for the prediction, prevention, and treatment of GDM and improve the outcome of pregnancy.

show abstract

Section: The Possible Mechanism Of Exosomes Participation In Gdmmentioning

confidence: 99%

The Mystery of Exosomes in Gestational Diabetes Mellitus

Chen

Liu

2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Both FNDC3A and FNDC3B have been located in the placenta (Obholz et al 2006), although a specific function has not been described. Several adipokines have been shown to alter placental nutrient transfer and fetal growth, including leptin (Nguyen-Ngo et al 2020), therefore a role can be proposed for FNDC3A and/or FNDC3B in fatty acid transport across the placenta. Sato et al (2006) cloned Fndc1 from a rat heart cDNA library by RT-PCR, which they designated Ags8 (Activator of G-protein Signaling 8).…”

Section: Functionmentioning

confidence: 99%

Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction

et al. 2022

View full text Add to dashboard Cite

Dietary stress such as obesity and short-term changes in energy balance can disrupt ovarian function leading to infertility. Adipose tissue secretes hormones (adipokines), such as leptin and adiponectin, that are known to alter ovarian function. Muscles can also secrete endocrine factors, and one such family of myokines, the eleven Fibronectin type III Domain-Containing (FNDC) proteins, is emerging as important for energy sensing and homeostasis. In this review we summarize the known roles the FNDC proteins play in energy homeostasis and explore potential impacts on fertility in females. The most well-known member, FNDC5, is the precursor of the 'exercise hormone', irisin, secreted by both muscle and adipose tissue. The receptors for irisin are integrins, and it has recently been shown to alter steroidogenesis in ovarian granulosa cells although the effects appear to be species or context specific, and irisin may improve uterine and placental function in women and rodent models. Another member, FNDC4, is also cleaved to release a bioactive protein that modulates insulin sensitivity in peripheral tissues and whose receptor, ADGRF5, is expressed in the ovary. As obese women and farm animals in negative energy balance (NEB) both have altered insulin sensitivity, secreted FNDC4 may impact ovarian function. We propose a model in which NEB or dietary imbalance alters plasma irisin and secreted FNDC4 concentrations, which then act on the ovary through their cognate receptors to reduce granulosa cell proliferation and follicle health. Research into these molecules will increase our understanding of energy sensing and fertility, and may lead to new approaches to alleviate post-partum infertility

show abstract

“…In 2021, about 14% of live birth pregnancies worldwide were complicated by GDM 6 . While the exact mechanism(s) leading to the development of insulin resistance in GDM are not yet fully understood, altered secretion of adipokines during pregnancy is attracting substantial attention 7–12 …”

Section: Introductionmentioning

confidence: 99%

Adipose tissue‐derived FABP4 mediates glucagon‐stimulated hepatic glucose production in gestational diabetes

Ron,

Mdah,

Zemet

et al. 2023

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

AimsOne of the most common complications of pregnancy is gestational diabetes mellitus (GDM), which may result in significant health threats of the mother, fetus and the newborn. Fatty acid‐binding protein 4 (FABP4) is an adipokine that regulates glucose homeostasis by promoting glucose production and liver insulin resistance in mouse models. FABP4 levels are increased in GDM and correlates with maternal indices of insulin resistance, with a rapid decline post‐partum. We therefore aimed to determine the tissue origin of elevated circulating FABP4 levels in GDM and to assess its potential contribution in promoting glucagon‐induced hepatic glucose production.Materials and MethodsFABP4 protein and gene expression was determined in biopsies from placenta, subcutaneous (sWAT) and visceral (vWAT) white adipose tissues from GDM and normoglycaemic pregnant women. FABP4 differential contribution in glucagon‐stimulated hepatic glucose production was tested in conditioned media before and after its immune clearance.ResultsWe showed that FABP4 is expressed in placenta, sWAT and vWAT of pregnant women at term, with a significant increase in its secretion from vWAT of women with GDM compared with normoglycaemic pregnant women. Neutralizing FABP4 from both normoglycaemic pregnant women and GDM vWAT secretome, resulted in a decrease in glucagon‐stimulated hepatic glucose production.ConclusionsThis study provides new insights into the role of adipose tissue‐derived FABP4 in GDM, highlighting this adipokine, as a potential co‐activator of glucagon‐stimulated hepatic glucose production during pregnancy.

show abstract

Role of adipose tissue in regulating fetal growth in gestational diabetes mellitus

Cited by 11 publications

References 175 publications

The Mystery of Exosomes in Gestational Diabetes Mellitus

The Mystery of Exosomes in Gestational Diabetes Mellitus

Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction

Adipose tissue‐derived FABP4 mediates glucagon‐stimulated hepatic glucose production in gestational diabetes

Contact Info

Product

Resources

About