Role of adjuvant external beam radiotherapy and chemotherapy in one versus two or more node-positive vulvar cancer: A National Cancer Database study

Radiotherapy is not indicated in patients with vulvar squamous cell carcinoma and only one occult intracapsular groin node metastasis

“…Despite these national recommendations, several recent studies have questioned this policy [12][13][14][15][17][18][19]. A summary of the literature on this subject is shown in Table 4.…”

“…A summary of the literature on this subject is shown in Table 4. Six out of 10 published studies recommend adjuvant radiotherapy in all patients, irrespective of the number of positive lymph nodes [12][13][14][15]17,19]. Three other studies do not recommend adjuvant radiotherapy [5,6,16], while the large AGO study could not show a significant difference in recurrence free survival with or without adjuvant radiotherapy and was therefore considered inconclusive [18].…”

“…The current ESGO guidelines [4] and most, but not all [7] other guidelines, recommend adjuvant radiotherapy, except for patients with one clinically occult and pathologically intracapsular lymph node metastasis [8][9][10][11]. However, some recent publications have questioned these recommendations and have recommended adjuvant radiotherapy for all patients with lymph node metastases, irrespective of the number and/or pathological characteristics of these metastases [12][13][14][15].…”

Metastatic Tracheal Tumor of Thyroid Origin: Endoscopic Diode Laser Treatment Combined With Thyroidectomy, Radioactive Iodine, and Radiotherapy

“…2 Surgical management of these patients, such as shaving of the tumor from the outside of the trachea, window, or tracheal resection and total laryngectomy, is still controversial as conservative treatment with radioiodine and external beam radiation renders significant results. 2,7 Mossetti et al performed radical resections of tracheal masses with minor complications in 8 patients. 8 Kim et al question the effectiveness of surgical resection of the tracheal mass in a big study involving 1919 patients with thyroid cancer, 65 of which (3.39%) had a tracheal involvement.…”

The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review

“…Groin and pelvic adjuvant RT should be administered for any nodal metastasis and/or close/involved margins unfit for further surgery. Large tumors, or those at high risk of surgical morbidity, are candidates for primary (chemo) radiation treatment, and multidisciplinary teams play an important role in the evaluation phase [ 11 , 12 , 13 , 14 , 15 ].…”