Role of Adjuvant Radiotherapy in Gastric Cancer

Yu, Jeong Il

doi:10.5230/jgc.2023.23.e1

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…Further studies on larger cohorts are required to confirm the potential of radiotherapy in microsatellite instability-high patients. even the most recent data indicate that adjuvant radiotherapy could be recommended as a therapy option only in patients with less than D2 lymphadenectomy or those with incompletely resected locally advanced tumors (16). the same study indicates that chemoradiotherapy does not improve survival in patients treated with platinum-based protocols.…”

Section: Resultsmentioning

confidence: 97%

Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy

Janković,

Ramić,

Kelava

et al. 2024

Lib Oncol

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gastric cancer remains one of the deadliest types of cancer despite the improvements in therapy regimens. the knowledge about specific molecular and histopathologic features of gastric tumors leads toward targeted therapy protocols. Patients with microsatellite instability-high cancer exhibit special characteristics regarding the response to therapy. these patients benefit from specific immunotherapy regimens and respond poorly to conventional therapy. Our study aimed to evaluate the effect of chemotherapy and chemoradiotherapy on the survival of patients with microsatellite instability gastric cancer in our institution. the results of our study show an increase in survival in the microsatellite instability-high group of patients who received radiotherapy (p=0.04). since all the recent studies recommend radiotherapy only in patients with incompletely resected disease or those with less than D2 lymphadenectomy, our study offers a novelty suggestion in consideration of therapeutic options. If the benefit of radiotherapy can be confirmed in a larger sample of patients, radiotherapy could be a part of tailored therapy for microsatellite instability-high (MSI-H) gastric cancer.

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Section: Resultsmentioning

confidence: 97%

Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy

Janković,

Ramić,

Kelava

et al. 2024

Lib Oncol

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“…ESMO guidelines advocate for the pre- and post-operative administration of FLOT regimen (5-FU, leucovorin, oxaliplatin, and docetaxel) in patients who can tolerate it [ 101 ]. The choice of the chemotherapy regimen may vary depending on the guideline, and the role of radiotherapy as an adjunct is still under investigation [ 105 , 106 , 107 ].…”

Section: Gastric Cancer Characterization Prognosis and Management In ...mentioning

confidence: 99%

Molecular Classifications in Gastric Cancer: A Call for Interdisciplinary Collaboration

Díaz del Arco,

Fernández Aceñero,

Ortega Medina

2024

IJMS

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Gastric cancer (GC) is a heterogeneous disease, often diagnosed at advanced stages, with a 5-year survival rate of approximately 20%. Despite notable technological advancements in cancer research over the past decades, their impact on GC management and outcomes has been limited. Numerous molecular alterations have been identified in GC, leading to various molecular classifications, such as those developed by The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG). Other authors have proposed alternative perspectives, including immune, proteomic, or epigenetic-based classifications. However, molecular stratification has not yet transitioned into clinical practice for GC, and little attention has been paid to alternative molecular classifications. In this review, we explore diverse molecular classifications in GC from a practical point of view, emphasizing their relationships with clinicopathological factors, prognosis, and therapeutic approaches. We have focused on classifications beyond those of TCGA and the ACRG, which have been less extensively reviewed previously. Additionally, we discuss the challenges that must be overcome to ensure their impact on patient treatment and prognosis. This review aims to serve as a practical framework to understand the molecular landscape of GC, facilitate the development of consensus molecular categories, and guide the design of innovative molecular studies in the field.

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Present and future advances in the treatment of esophagogastric cancer

Bonilla,

Ávila,

Jiménez

et al. 2023

Med.

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El cáncer esofagogástrico es un problema de salud pública a nivel mundial y una de las principales causas de mortalidad principalmente en países de ingresos medios y bajos con aumento importante en lugares con estilos de vida occidental. A pesar de los avances significativos en la última década en relación con biomarcadores y tratamiento, persiste con cifras de supervivencia bajas, lo que indica la necesidad de estrategias de medicina de precisión en terapia dirigida molecularmente. Esta revisión analiza el panorama actual de diagnóstico con perfil molecular y tratamiento en los diferentes escenarios de enfermedad temprana, localmente avanzada y metastásica en cáncer esofagogástrico y los desafíos de los avances a futuro de desarrollo y evolución de nuevos biomarcadores y objetivos terapéuticos emergentes como las técnicas quirúrgicas, el progreso de la radioterapia, terapia dirigida, génica e inmunoterapia, que aumentan la esperanza en el tratamiento y abordaje de estas enfermedades.

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Role of Adjuvant Radiotherapy in Gastric Cancer

Cited by 3 publications

References 57 publications

Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy

Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy

Molecular Classifications in Gastric Cancer: A Call for Interdisciplinary Collaboration

Present and future advances in the treatment of esophagogastric cancer

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