Role of adrenergic receptors in the reflex diuresis in rabbits during pulmonary lymphatic obstruction

McCormick, K. M.; Bravo, Emigdio; Kappagoda, C. T.

doi:10.1113/expphysiol.2004.028654

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…The caudal end of the SVC is on the right‐hand bottom corner, and the cranial end is in the opposite corner. Reproduced with permission from McCormick et al (2005).…”

Section: Effect Of Altering Oncotic Pressure On Rar Activitymentioning

confidence: 99%

The rapidly adapting receptors in mammalian airways and their responses to changes in extravascular fluid volume

Kappagoda

Ravindran

2006

Experimental Physiology

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In this short review, we shall focus on some recent findings on the physiological stimulus for the rapidly adapting receptors (RAR) of the airways. They are readily activated by a sustained inflation of the lungs and they are usually identified by their rapid adaptation to this stimulus. They are also activated by both tactile stimuli and irritant gases applied to the epithelium of the airways. The investigations reviewed here suggest that these receptors are activated by changes in extravascular fluid volume. The principal factors governing fluid flux from the microcirculation are identified in the Starling equation. These are the hydrostatic pressure, plasma oncotic pressure and capillary permeability. Findings from recent studies suggest that all these factors increase the activity of RAR. In addition, these receptors are also activated by obstruction of lymph drainage from the lung. Evidence is presented to show that manipulation of Starling forces also increases the extravascular fluid volume of the airways in areas where the RAR are located. On the basis of these findings, it is suggested that, along with mechanosensitivity to stimuli such as stretch, inflation and deflation, another physiological stimulus to the RAR is a change in extravascular fluid volume in the regions of the airways where these receptors are located.

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“…The caudal end of the SVC is on the right‐hand bottom corner, and the cranial end is in the opposite corner. Reproduced with permission from McCormick et al (2005).…”

Section: Effect Of Altering Oncotic Pressure On Rar Activitymentioning

confidence: 99%

The rapidly adapting receptors in mammalian airways and their responses to changes in extravascular fluid volume

Kappagoda

Ravindran

2006

Experimental Physiology

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“…33 There are reports which show that the renal NO generation is mediated by activation of alpha-2 receptors. 34 These studies establish that sympathetic excitation can lead to NO generation by activation of nNOS through alpha-2 receptors. 34 Further evidences in support of these propositions are provided by the observations of Mount and Power 35 who demonstrated that in the kidney, NO was involved in promoting natriuresis and diuresis and Majid and Navar 36 who reported that NO was involved in pressure natriuresis.…”

Section: Discussionmentioning

confidence: 87%

“…34 These studies establish that sympathetic excitation can lead to NO generation by activation of nNOS through alpha-2 receptors. 34 Further evidences in support of these propositions are provided by the observations of Mount and Power 35 who demonstrated that in the kidney, NO was involved in promoting natriuresis and diuresis and Majid and Navar 36 who reported that NO was involved in pressure natriuresis. While evaluating the role of NO, it is emphasised that the NO generated may produce antinatriuresis and antidiuresis also depending upon its site of action and the existing sympathetic drive.…”

Section: Discussionmentioning

confidence: 87%

Role of Nitric Oxide in the Diuresis and Natriuresis Occurring in Patients with Obstructive Sleep Apnoea Syndrome

Singh¹,

Patial²,

Vijayan³

et al. 2022

The Indian Journal of Chest Diseases and Allied Sciences

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Objective. To determine whether nitric oxide (NO) has any role in the diuresis and natriuresis observed in patients with obstructive sleep apnoea syndrome (OSAS).Methods. We measured 12-hour urine volume in the day and in the night in patients with OSAS (n=20) and determined the concentrations of urinary sodium and nitrate. The frequency of urination in the night was also noted. The measurements were done again after two nights of continuous positive airway pressure (CPAP) therapy and after putting the patients on oral anti-oxidant treatment (vitamin C-100mg BD and vitamin E-400IU BD) for 45 days. Ten healthy normal subjects underwent the same protocol except the CPAP therapy. Results.In patients with OSAS, the night urine volume and sodium concentration were similar and the nitrate levels were higher compared to those in the day. After CPAP therapy, while the urine volume and sodium concentration decreased, the nitrate level became similar to that in the day. Such effects were not observed after anti-oxidant treatment. The frequency of urination was decreased in both the instances. The effects observed after CPAP therapy were similar to those observed in control subjects with or without anti-oxidant treatment. Conclusion.Renal NO promotes diuresis and natriuresis in patients with OSAS.

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Sensory Nerves in Lung and Airways

Lee

2014

Comprehensive Physiology

115

157

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Sensory nerves innervating the lung and airways play an important role in regulating various cardiopulmonary functions and maintaining homeostasis under both healthy and disease conditions. Their activities conducted by both vagal and sympathetic afferents are also responsible for eliciting important defense reflexes that protect the lung and body from potential health-hazardous effects of airborne particulates and chemical irritants. This article reviews the morphology, transduction properties, reflex functions, and respiratory sensations of these receptors, focusing primarily on recent findings derived from using new technologies such as neural immunochemistry, isolated airway-nerve preparation, cultured airway neurons, patch-clamp electrophysiology, transgenic mice, and other cellular and molecular approaches. Studies of the signal transduction of mechanosensitive afferents have revealed a new concept of sensory unit and cellular mechanism of activation, and identified additional types of sensory receptors in the lung. Chemosensitive properties of these lung afferents are further characterized by the expression of specific ligand-gated ion channels on nerve terminals, ganglion origin, and responses to the action of various inflammatory cells, mediators, and cytokines during acute and chronic airway inflammation and injuries. Increasing interest and extensive investigations have been focused on uncovering the mechanisms underlying hypersensitivity of these airway afferents, and their role in the manifestation of various symptoms under pathophysiological conditions. Several important and challenging questions regarding these sensory nerves are discussed. Searching for these answers will be a critical step in developing the translational research and effective treatments of airway diseases.

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Role of adrenergic receptors in the reflex diuresis in rabbits during pulmonary lymphatic obstruction

Cited by 6 publications

References 22 publications

The rapidly adapting receptors in mammalian airways and their responses to changes in extravascular fluid volume

The rapidly adapting receptors in mammalian airways and their responses to changes in extravascular fluid volume

Role of Nitric Oxide in the Diuresis and Natriuresis Occurring in Patients with Obstructive Sleep Apnoea Syndrome

Sensory Nerves in Lung and Airways

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