Role of AGC kinases in plant growth and stress responses

García, Ana Victoria Torres; Alyousif, Mohamed S; Hirt, Heribert

doi:10.1007/s00018-012-1093-3

Cited by 47 publications

(39 citation statements)

References 84 publications

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“…Because OXI1 also is involved in root-hair growth and can phosphorylate different members of the RLCK-VIII subfamily, OXI1 is likely to activate MRI during root-hair growth. In PTs, however, OXI1 expression levels are very low, and it seems more likely that either another member of this family, the AGC2 kinases (group VIII), or a combination of them fulfills this role (Table S5) (35)(36)(37). Whether CrRLK1Ls, NADPH oxidases, OXI1/ AGC2 kinases, and MRI/Pti1-like proteins are all part of a linear pathway or, more likely, belong to different pathways that orchestrate complex cross-talk to sustain cell growth remains to be addressed.…”

Section: Discussionmentioning

confidence: 99%

“…Whether CrRLK1Ls, NADPH oxidases, OXI1/ AGC2 kinases, and MRI/Pti1-like proteins are all part of a linear pathway or, more likely, belong to different pathways that orchestrate complex cross-talk to sustain cell growth remains to be addressed. In this regard, the presence of a module composed of OXI/AGC2 kinases and MRI/Pti1-like RLCKs acting downstream of the CrRLK1Ls and NADPH oxidases could potentially allow the integration of inputs generated by biotic or abiotic stresses with the CW integrity pathway (36,37). Interestingly, in all the different genetic backgrounds tested, MRI R240C is more efficient than the WT form in activating downstream responses.…”

Section: Discussionmentioning

confidence: 99%

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Receptor-like cytoplasmic kinase MARIS functions downstream of Cr RLK1L-dependent signaling during tip growth

Boisson-Dernier

Franck

Lituiev

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

120

140

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Growing plant cells need to rigorously coordinate external signals with internal processes. For instance, the maintenance of cell wall (CW) integrity requires the coordination of CW sensing with CW remodeling and biosynthesis to avoid growth arrest or integrity loss. Despite the involvement of receptor-like kinases (RLKs) of the Catharanthus roseus RLK1-like (CrRLK1L) subfamily and the reactive oxygen species-producing NADPH oxidases, it remains largely unknown how this coordination is achieved. ANXUR1 (ANX1) and ANX2, two redundant members of the CrRLK1L subfamily, are required for tip growth of the pollen tube (PT), and their closest homolog, FERONIA, controls root-hair tip growth. Previously, we showed that ANX1 overexpression mildly inhibits PT growth by oversecretion of CW material, whereas pollen tubes of anx1 anx2 double mutants burst spontaneously after germination. Here, we report the identification of suppressor mutants with improved fertility caused by the rescue of anx1 anx2 pollen tube bursting. Mapping of one these mutants revealed an R240C nonsynonymous substitution in the activation loop of a receptor-like cytoplasmic kinase (RLCK), which we named MARIS (MRI). We show that MRI is a plasma membranelocalized member of the RLCK-VIII subfamily and is preferentially expressed in both PTs and root hairs. Interestingly, mri-knockout mutants display spontaneous PT and root-hair bursting. Moreover, expression of the MRI R240C mutant, but not its wild-type form, partially rescues the bursting phenotypes of anx1 anx2 PTs and fer root hairs but strongly inhibits wild-type tip growth. Thus, our findings identify a novel positive component of the CrRLK1L-dependent signaling cascade that coordinates CW integrity and tip growth.receptor-like kinase signaling | cell wall integrity | pollen tube | root hair | Arabidopsis

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Receptor-like cytoplasmic kinase MARIS functions downstream of Cr RLK1L-dependent signaling during tip growth

Boisson-Dernier

Franck

Lituiev

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

120

140

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“…In mammalian systems, AGC kinases are important regulators of cell growth, metabolism, and cell death (Pearce et al, 2010). Although the catalytic kinase domains of plant AGC kinases share sequence similarities with those of mammalian AGC kinases, their molecular functions and targets are largely unknown (Garcia et al, 2012). In the Arabidopsis genome, there are 39 AGC kinase members (Bögre et al, 2003).…”

Section: Oxi1 Is a New Regulator Of High-light-induced Cell Death In mentioning

confidence: 99%

“…In the Arabidopsis genome, there are 39 AGC kinase members (Bögre et al, 2003). To date, in different model plant species, several AGC kinases have been implicated in various developmental and physiological processes, including growth, morphogenesis, defense, and symbiosis (Rentel et al, 2004;Abuqamar et al, 2008;Fu et al, 2009;Garcia et al, 2012;Rademacher and Offringa, 2012;Zhu et al, 2015). In Arabidopsis, OXI1 is required for immunity against the pathogenic oomycete Hyaloperonospora arabidopsidis and the bacterial biotrophic pathogen Pseudomonas syringae pv tomato DC3000 (Rentel et al, 2004;Petersen et al, 2009).…”

Section: Oxi1 Is a New Regulator Of High-light-induced Cell Death In mentioning

confidence: 99%

Singlet Oxygen-Induced Cell Death in Arabidopsis under High-Light Stress Is Controlled by OXI1 Kinase

Shumbe

Chevalier²,

Légeret³

et al. 2016

Plant Physiol.

113

126

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ORCID ID: 0000-0001-7912-7220 (F.M.). Studies of the singlet oxygen (1 O 2 )-overproducing flu and chlorina1 (ch1) mutants of Arabidopsis (Arabidopsis thaliana) have shown that 1 O 2 -induced changes in gene expression can lead to either programmed cell death (PCD) or acclimation. A transcriptomic analysis of the ch1 mutant has allowed the identification of genes whose expression is specifically affected by each phenomenon. One such gene is OXIDATIVE SIGNAL INDUCIBLE1 (OXI1) encoding an AGC kinase that was noticeably induced by excess light energy and 1 O 2 stress conditions leading to cell death. Photo-induced oxidative damage and cell death were drastically reduced in the OXI1 null mutant (oxi1) and in the double mutant ch1*oxi1 compared with the wild type and the ch1 single mutant, respectively. This occurred without any changes in the production rate of 1 O 2 but was cancelled by exogenous applications of the phytohormone jasmonate. OXI1-mediated 1 O 2 signaling appeared to operate through a different pathway from the previously characterized OXI1-dependent response to pathogens and H 2 O 2 and was found to be independent of the EXECUTER proteins. In high-light-stressed plants, the oxi1 mutation was associated with reduced jasmonate levels and with the up-regulation of genes encoding negative regulators of jasmonate signaling and PCD. Our results show that OXI1 is a new regulator of 1 O 2 -induced PCD, likely acting upstream of jasmonate.

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“…Moreover, defects in the INCOMPLETE ROOT HAIR ELONGATION (IRE) gene, which encodes another AGC protein kinase, caused a similar short-root-hair phenotype to agc2-1 mutants (Oyama et al, 2002). These findings, together with the existence of numerous AGC kinases in plants (Garcia et al, 2012), suggest that AGC protein kinase cascades integrate various signals including phospholipids and ROS in the regulation of root hair tip growth. It is noteworthy that PDK1 phosphorylates PIONOID (PID), the AGC protein kinase that modulates auxin polar transport via the phosphorylation of PINFORMED (PIN) auxin transporters (Zegzouti et al, 2006;Huang et al, 2010).…”

Section: Signal Integration By Phosphoinositide Interactorsmentioning

confidence: 75%