Role of aldose reductase in Ischemic Heart Disease in subjects visiting Punjab Institute of Cardiology, Lahore

Abstract

Background: Ischemic heart disease (IHD) is one of the major cardiovascular diseases due to insufficient blood supply to cardiac cells. Aldose reductase (AR) is a multifunctional enzyme that converts glucose into sorbitol in the polyol pathway. The main objective of this study is to determine the role of aldose reductase in ischemic heart disease subjects in our local population and its relationship with lipid profile. Methods: This cross-sectional study sampled 100 subjects from Jelani Block of PIC Lahore after ethical approval, categorized into two groups depending on disease condition, i.e., the IHD (n=50) group and Control Group (n=50), including healthy subjects. They were taken together with disease history, age, smoking, hypertension, and physical activity examined as inclusion criteria. The level of biochemical parameters was evaluated by using a chemistry analyzer. Hormonal (AR) and cardiac marker (CK-MB) assessments were performed on the ELISA system using commercially available ELSA diagnostic kits. Results: The results revealed that levels of aldose reeducate and CK-MB was comparatively more significant in the IHD group than control, but total cholesterol (TC), triglycerides (TG), and high-density lipoproteins (HDL) showed no significant difference between the control and IHD group. Conclusion: A statistically non-significant relationship was observed between aldose reductase and CK-MB and lipid profile in the IHD patients, indicating the role of aldose reductase in IHD subjects because it increases oxidative stress in cardiac cells.