Role of Alendronate in Managing Osteoporosis in Celiac Disease – Illustrative Case Report

Widjaja,

doi:10.4021/gr279w

Cited by 2 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…have reported improvement in T-score and Z-score in a single patient of CD with osteoporosis after 18 months of oral alendronate use in a dose of 10 mg/day. [ 30 ] All our patients showed remarkable improvement in clinical, biochemical, and radiological parameters with gluten-free diet, calcium, and vitamin D supplementation.…”

Section: Discussionmentioning

confidence: 83%

Celiac disease: A missed cause of metabolic bone disease

Rastogi

Bhadada

Bhansali

et al. 2012

Indian J Endocr Metab

View full text Add to dashboard Cite

Introduction:Celiac disease (CD) is a highly prevalent autoimmune disease. The symptoms of CD are varied and atypical, with many patients having no gastrointestinal symptoms. Metabolic bone disease (MBD) is a less recognized manifestation of CD associated with spectrum of musculoskeletal signs and symptoms, viz. bone pains, proximal muscle weakness, osteopenia, osteoporosis, and fracture. We here report five patients who presented with severe MBD as the only manifestation of CD.Materials and Methods:Records of 825 patients of CD diagnosed during 2002–2010 were retrospectively analyzed for clinical features, risk factors, signs, biochemical, and radiological parameters.Results:We were able to identify five patients (0.6%) of CD who had monosymptomatic presentation with musculoskeletal symptoms and signs in the form of bone pains, proximal myopathy, and fragility fractures without any gastrointestinal manifestation. All the five patients had severe MBD in the form of osteopenia, osteoporosis, and fragility fractures. Four of the five patients had additional risk factors such as antiepileptic drugs, chronic alcohol consumption, malnutrition, and associated vitamin D deficiency which might have contributed to the severity of MBD.Conclusion:Severe metabolic disease as the only presentation of CD is rare. Patients show significant improvement in clinical, biochemical, and radiological parameters with gluten-free diet, calcium, and vitamin D supplementation. CD should be looked for routinely in patients presenting with unexplained MBD.

show abstract

Section: Discussionmentioning

confidence: 83%

Celiac disease: A missed cause of metabolic bone disease

Rastogi

Bhadada

Bhansali

et al. 2012

Indian J Endocr Metab

View full text Add to dashboard Cite

show abstract

“…Medicamentous therapy of osteoporosis is initiated parallel with the start of celiac disease therapy if T-score is below -1.5 SD in the presence of other risk factors or previous small trauma fracture or if T-score is below -3.0 SD independently of the presence of other risk factors. Medicamentous therapy of osteoporosis implies bisphosphonates 27 , selective estrogen receptor modulators, calcitonine, bone anabolic (teriparatide), strontium r nelate with adequate supplementation of vitamin D and calcium 28 .…”

Section: Discussionmentioning

confidence: 99%