Role of Alpha-Klotho Protein in Fibrogenesis at Different Stages of Diabetic Nephropathy

Abstract

Introduction: Alpha Klotho protein monitoring in diabetic nephropathy patients is important because the deciency appears to be a risk factor for the development and progression of diabetic nephropathy and thus has prognostic value. There is conicting evidence regarding the relationship between Alpha Klotho protein and brogenesis in diabetic nephropathy. A 2-year cross-s Methods: ectional study of 120 diabetic patients, with and without nephropathy enrolled at MES Medical College. Alpha Klotho protein and the brogenesis regulator, TGF-β1 were measured using ELISA. Results: Conclusion: In diabetic nephropathy patients, Alpha-Klotho protein had a signicant negative correlation with TGF-β1 and eGFR. Alpha-Klotho protein levels have been found to be lower in diabetic nephropathy patients and signicantly related to the severity of the disease. Alpha-KL protein also correlated signicantly with the marker of brogenesis, TGF- beta 1. So it has a value as a prognostic marker and role in preventing brogenesis in diabetic patients.