Role of altered cerebello-thalamo-cortical network in the neurobiology of essential tremor

Lenka, Abhishek; Bhalsing, Ketaki Swapnil; Panda, Rajanikant; Jhunjhunwala, Ketan; Naduthota, Rajini M; Saini, Jitender; Bharath, Rose Dawn; Yadav, Ravi; Pal, Pramod Kumar

doi:10.1007/s00234-016-1771-1

Cited by 77 publications

(41 citation statements)

References 28 publications

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“…In older models of ET, the inferior olivary nucleus (ION) was also included, and it was this structure that was posited to drive the tremor. However, this older model has fallen out of favor [ 18 , 19 ] for a number of reasons, including the normal appearance of the ION on most neuroimaging studies [ 3 , 20 – 22 ] as well as on postmortem comparisons of ET and control brains [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Inferior Olivary nucleus degeneration does not lessen tremor in essential tremor

et al. 2018

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BackgroundIn traditional models of essential tremor, the inferior olivary nucleus was posited to play a central role as the pacemaker for the tremor. However, recent data call this disease model into question.Case presentationOur patient had progressive, long-standing, familial essential tremor. Upper limb tremor began at age 10 and worsened over time. It continued to worsen during the nine-year period he was enrolled in our brain donation program (age 85 – 94 years), during which time the tremor moved from the moderate to severe range on examination. On postmortem examination at age 94, there were degenerative changes in the cerebellar cortex, as have been described in the essential tremor literature. Additionally, there was marked degeneration of the inferior olivary nucleus, which was presumed to be of more recent onset. Such degeneration has not been previously described in essential tremor postmortems. Despite the presence of this degeneration, the patient’s tremor not only persisted but it continued to worsen during the final decade of his life.ConclusionsAlthough the pathophysiology of essential tremor is not completely understood, evidence such as this suggests that the inferior olivary nucleus does not play a critical role in the generation of tremor in these patients.

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Section: Introductionmentioning

confidence: 99%

Inferior Olivary nucleus degeneration does not lessen tremor in essential tremor

et al. 2018

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“…Other than the pontine tegmentum, brain regions with higher glucose metabolism in this study are components of the cerebello-thalamo-cortical loop, which is presumably altered in patients with ET. 25 , 26 Further evidence of involvement of the cerebellum and its connections was revealed in a rs-fMRI study ( Table 2 ). 23 In that study, the connectivity between the cerebellar hemispheres and supplementary motor cortex was significantly increased in patients with primary OT compared with controls, and it correlated with the disease duration and tremor severity.…”

Section: Resultsmentioning

confidence: 86%

Pathogenesis of Primary Orthostatic Tremor: Current Concepts and Controversies

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et al. 2017

Tremor and Other Hyperkinetic Movements

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“…An ever-growing number of recent fMRI studies have also not detected any alterations in the functional connectivity of the ION; rather, an alteration in the cortico-bulbo-cerebello-thalamo-cortical network (and especially the cerebellum) has been the major result of these studies. 39 – 42 Magnetic resonance spectroscopy (MRS) is a neuroimaging technique that allows in vivo quantification of certain chemicals in the brain. Studies using MRS have compared the ratio of N -acetylaspartate (NAA) and creatine (Cr) in patients with ET and healthy controls.…”

Section: Methodsmentioning

confidence: 99%