Role of ?-aminobutyric acid (GABA) in the extrapyramidal motor system 1. Regional distribution of GABA in rabbit, rat, guinea pig and baboon CNS

GABAergic output of the basal ganglia

“…1(C)). Since SNr neurons express an extremely high concentration of GABA A receptors (Fahn and Cote, 1968;Okada et al, 1971) reflecting abundant GABAergic inputs from the striatum (caudate nucleus and putamen) and the external segment of the GP e (Smith and Bolam, 1991), the injected muscimol would bind to the GABA A receptors and suppress the rapid and tonic firing. This chemical manipulation would effectively remove the SNr-SC inhibition.…”

Effect of .GAMMA.-aminobutyric acid on excitability of tubero-infundibular neurons in rat hypothalamic slices.

“…High levels of GABA concentration and glutamic acid decarboxylase activity were demonstrated in the hypothalamus and preoptic area (Okada et al, 1971 ;Makara et al, 1975 ;Fonnum et al, 1977) and the effect of GABA on neuroendocrine functions has been reported by several investigators. Vijayan and McCann (1978) showed the stimulatory effect of intraventricular GABA on LH secretion.…”

“…neurotransmitter which hyperpolarizes the neural membrane (Obata et al, 1967;Curtis et al, 1968;Dreifuss et al, 1969) and is present in high concentrations in the hypothalamus and preoptic area (Okada et al, 1971;Makara et al, 1975;Fonnum et al, 1977). In these areas, a large number of perikarya of tubero-infundibular (TI) neurons controlling the anterior pituitary hormone secretion are also found (Palkovits, 1982), and the effect of GABA on neuroendocrine functions has been investigated (Kordon et al, 1980).…”

Preliminary Studies on GABA-immunoreactive Neurons in the Rat Trigeminal Ganglion

“…The regional and wide distribution of GABA was reported in the brain of some mammals, i.e., substantia nigra, globus pallidus and hypothalamus (Okada et al, 1971). Moreover, there have been many evidences that GABA is present in the superficial dorsal horn of the rat and the mouse spinal cord (Magoul et Roy et al (1991) provided an evidence that GABA is contained within cells of the chick dorsal root ganglia (DRG).…”