Role of Amniotic Membrane Transplantation in Corneal Ulcers

Chauhan, Ramesh Chand; Chhikara, Chetan; Rathi, Ashok; Chugh, Joginder Pal; Goel, Ashiya; Sumpi, Chinging

doi:10.36348/sjmps.2021.v07i02.007

Cited by 3 publications

(3 citation statements)

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“…Although AMT causes corneal opacification in the early phase, it will dissolve in the weeks following the procedure, and vision will improve as a result of the restoration of the corneal surface. 2,12 In this study, there was a high success rate, where 3368 corneal ulcers, either moderate or severe corneal ulcers. There was no significant difference in the success rate for moderate or severe ulcers (p = 0792).…”

Section: Based On Inclusion and Exclusion Criteria 52mentioning

confidence: 62%

“…In cases of corneal ulcers that do not respond to medical therapy, surgical intervention is needed, one of which is an Amniotic Membrane Transplantation (AMT) graft. [1][2][3][4] Amniotic membrane (AM) is the innermost layer of the fetal membrane. AM thickness varies between 0.02-0.05 mm and consists of 3 histological layers: epithelial layer, thick basement membrane, and avascular stroma.…”

Section: Introductionmentioning

confidence: 99%

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Surgical Outcome of Amniotic Membrane Transplantation (AMT) in Patients with Corneal Ulcer in Dr. M. Djamil Hospital Padang Indonesia

Sari

Vitresia

2023

Bioscmed

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Background: Amniotic Membrane Transplantation or AMT Graft has been known to successfully manage ocular surface diseases, especially corneal ulcers. The amniotic membrane promotes epithelialization and inhibits proteinase activity that is required for wound healing. A corneal ulcer is a potentially sight-threatening condition resulting in permanent corneal opacity. Methods: This is a retrospective descriptive study. Subjects were patients diagnosed with corneal ulcers and have been treated with AMT grafts. The data were grouped according to age, gender, severity, cause, visual acuity before and after AMT, and time required for complete epithelialization. Results: Fifty-two patients were included in this study, aged 41-50, with a mean age of 43,17. Men were more common than women by 88,5% vs 11,5%. AMT graft was performed for moderate and severe corneal ulcers in this study, and most of them were caused by infection. The visual acuity before AMT was mostly in the second WHO category of blindness and visual impairment. Four weeks after surgery, 34.6% of patients had improved visual acuity. Complete epithelialization was most frequently (59,6%) achieved in 15-28 days. AMT graft was repeated in 3 patients, and other surgical interventions were required for 2 patients. Conclusion: The AMT graft has successfully managed corneal ulcer patients, especially in moderate to severe cases, in Dr. M. Djamil General Hospital, Padang, Indonesia.

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Section: Based On Inclusion and Exclusion Criteria 52mentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Surgical Outcome of Amniotic Membrane Transplantation (AMT) in Patients with Corneal Ulcer in Dr. M. Djamil Hospital Padang Indonesia

Sari

Vitresia

2023

Bioscmed

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“…Keratoplasty in corneal thinning and perforation Corneal thinning and perforation may result in permanent vision loss, and immediate surgical intervention is needed to prevent catastrophic consequences such as endophthalmitis [12] . Temporary therapies for this situation including corneal gluing [13][14][15] , bandage contact lenses [16][17][18][19] , amniotic membrane transplantation [20][21][22] , scleral graft, and conjunctival flap [23][24][25][26] have unsatisfactory long-term results. Furthermore, tectonic lamellar or penetrating keratoplasty (PK) is the most recommended treatment for most patients with extensive corneal lesions [27][28] .…”

Section: Keratoplastymentioning

confidence: 99%

Applications of SMILE-extracted lenticules in ophthalmology

Aghamollaei,

Fallahtafti,

Daryabari

et al. 2024

Int J Ophthalmol

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AIM: To review recent innovations, challenges, and applications of small incision lenticule extraction (SMILE) extracted lenticule for treating ocular disorders. METHODS: A literature review was performed in the PubMed database, which was last updated on 30 December 2021. There was no limit regarding language. The authors evaluated the reference lists of the collected papers to find any relevant research. RESULTS: Due to the simplicity and accuracy of modern femtosecond lasers and the extensive development of SMILE surgery, many healthy human corneal stromal lenticules were extracted during surgery, motivating some professionals to investigate the SMILE lenticule reusability in different ocular disorders. In addition, new approaches had been developed to preserve, modify, and bioengineer the corneal stroma, leading to the optimal use of discarded byproducts such as lenticules from SMILE surgery. The lenticules can be effectively re-implanted into the autologous or allogenic corneas of human subjects to treat refractive errors, corneal ectasia, and corneal perforation and serve as a patch graft for glaucoma drainage devices with better cosmetic outcomes. CONCLUSION: SMILE-extracted lenticules could be a viable alternative to human donor corneal tissue.

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