Role of AMP-activated protein kinase in metabolic depression in animals

Rider, Mark H.

doi:10.1007/s00360-015-0920-x

Cited by 44 publications

(32 citation statements)

References 130 publications

(172 reference statements)

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“…However, given its crucial role in sensing and responding to changes in fuel status, AMPK is likely involved in the integrative response to natural bouts of fasting and the metabolic depression that accompanies some fasting states (455). Among studies that have examined AMPK in species that normally fast in the wild are several from hibernating species (179).…”

Section: Nutrient and Energy Sensing During Fastingmentioning

confidence: 98%

Integrative Physiology of Fasting

Secor

Carey

2016

Comprehensive Physiology

150

144

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Extended bouts of fasting are ingrained in the ecology of many organisms, characterizing aspects of reproduction, development, hibernation, estivation, migration, and infrequent feeding habits. The challenge of long fasting episodes is the need to maintain physiological homeostasis while relying solely on endogenous resources. To meet that challenge, animals utilize an integrated repertoire of behavioral, physiological, and biochemical responses that reduce metabolic rates, maintain tissue structure and function, and thus enhance survival. We have synthesized in this review the integrative physiological, morphological, and biochemical responses, and their stages, that characterize natural fasting bouts. Underlying the capacity to survive extended fasts are behaviors and mechanisms that reduce metabolic expenditure and shift the dependency to lipid utilization. Hormonal regulation and immune capacity are altered by fasting; hormones that trigger digestion, elevate metabolism, and support immune performance become depressed, whereas hormones that enhance the utilization of endogenous substrates are elevated. The negative energy budget that accompanies fasting leads to the loss of body mass as fat stores are depleted and tissues undergo atrophy (i.e., loss of mass). Absolute rates of body mass loss scale allometrically among vertebrates. Tissues and organs vary in the degree of atrophy and downregulation of function, depending on the degree to which they are used during the fast. Fasting affects the population dynamics and activities of the gut microbiota, an interplay that impacts the host's fasting biology. Fasting-induced gene expression programs underlie the broad spectrum of integrated physiological mechanisms responsible for an animal's ability to survive long episodes of natural fasting.

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Section: Nutrient and Energy Sensing During Fastingmentioning

confidence: 98%

Integrative Physiology of Fasting

Secor

Carey

2016

Comprehensive Physiology

150

144

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“…The rooted trees of the α and β subunits suggest that vertebrate PRKAA1/A2 and PRKAB1/B2 genes arose by duplications of ancestral genes in lower eukaryotes. The evolutionary trees also show a higher mutation rate of β (1.8183 substitutions per site) compared to α (1.1024 substitutions per site) indicating that the β subunit evolved 1.65 times faster than the α subunit [8]. The N-terminus of the α subunit contains the catalytic domain as well as a phosphorylation site for upstream kinases that regulate its activity [9].…”

Section: Ampk Subunit Structure: Unanswered Questions and The Brewingmentioning

confidence: 99%

Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer

Dasgupta

Chhipa

2016

Trends in Pharmacological Sciences

110

120

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AMP kinase (AMPK) is an evolutionarily conserved enzyme required for adaptive responses to various physiological and pathological conditions. AMPK executes numerous cellular functions, some of which are often perceived at odds with each other. While AMPK is essential for embryonic growth and development, its full impact in adult tissues is revealed under stressful situations that organisms face in the real world. Conflicting reports about its cellular functions, particularly in cancer, are intriguing and a growing number of AMPK activators are being developed to treat human diseases such as cancer and diabetes. Whether these drugs will have only context-specific benefits or detrimental effects in the treatment of human cancer will be a subject of intense research. Here we review the current state of AMPK research with an emphasis on cancer and discuss the yet unresolved context-dependent functions of AMPK in human cancer.

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“…Elevated expression of AMPK in muscle tissues (indicative of the cellular energy stress) was observed during the dry period in all muscles of R. jimi and in plantaris muscle of P. diplolister . An increase in AMPK levels is common during the resource- and energy-limited periods in many organisms including hibernating mammals [43,44] and frogs exposed to hypothermia, hypoxia, freezing, dehydration or anoxia [45,46,44]. Furthermore, AMPK suppresses energy-demanding metabolic processes [47,22] and induces cell cycle arrest [12,22,44], which also contributes to energy savings.…”

Section: Discussionmentioning

confidence: 99%

Biomarker-based assessment of the muscle maintenance and energy status of anurans from an extremely seasonal semi-arid environment, the Brazillian Caatinga

Madelaire

Gomes

Sokolova

2018

Preprint

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We studied seasonal variation of key metabolic regulators in the muscles of anurans that 21 experience drastic variation in environmental conditions and differ in the seasonal 22 activity patterns. 23 2 24 Abstract 25 Strongly seasonal environments pose challenges for performance and survival of 26 animals, especially when resource abundance seasonally fluctuates. We investigated the 27 seasonal variation of expression of key metabolic biomarkers in the muscles of three 28 species of anurans from the drastically seasonal Brazilian semi-arid area, Caatinga. The 29 three studied anuran species (Rhinella jimi, R. granulosa and Pleurodema diplolister) 30 differ in their seasonal activity patterns. We examined the expression of proteins 31 regulating energy turnover (AMP-activated protein kinase [AMPK] and protein kinase 32 B [AKT]), protein synthesis and homeostasis (total and phosphorylated eukaryotic 33 initiation factor 2α [eIF2α and p-eIF2α] and chaperone proteins [HSP 60, 70, and 90]) 34 in muscles related to reproduction and locomotion. Cytochrome c oxidase (COX) 35 activity was also assessed as an index of the muscle aerobic capacity. Our results point 36 to the importance of metabolic regulators mediating the muscular function during the 37 drastic seasonal variation. The toads that remain active during the drought appear to 38 maintain muscles through more energy extensive pathways including elevated protein 39 synthesis, while the aestivating species employs energy conservation strategy 40 suppressing protein synthesis, decreasing chaperone expression and increasing 41 expression of AMPK. All three studied species activate cell survival pathways during 42 the drought likely to prevent muscle atrophy, and maintain the muscle capacity 43 throughout the year, despite the resource limitation. These strategies are important 44 considering the unpredictability of the reproductive event and high demand on muscular 45 activity during the reproductive season in these amphibians. 3 47 Introduction 48 Strongly seasonal environments characterized by large changes in conditions 49 such as temperature and food availability, pose challenges to the organisms that need to 50 adjust their functions to survive and complete their life cycles [1, 2]. These 51 physiological adjustments are dependent on biochemical regulators and cell signaling 52 pathways that mediate cell survival, ensure cell and organ integrity and prioritize the use 53 of energy to meet the (often conflicting) needs of survival, growth and reproduction 54 [1,3]. In vertebrate ectotherms, the skeletal muscle physiology and performance are 55 directly related to the overall fitness due to the muscles' involvement in courtship, 56 territorial defense, foraging, escape from predators, mating interactions and migration 57 [4]. In seasonally fluctuating environments, skeletal muscles can display phenotypic 58 changes such as atrophy and changes in the fiber number and type during extreme 59 environmental stress and/or resource limitation [5]. Nevertheless, anuran ...

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Role of AMP-activated protein kinase in metabolic depression in animals

Cited by 44 publications

References 130 publications

Integrative Physiology of Fasting

Integrative Physiology of Fasting

Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer

Biomarker-based assessment of the muscle maintenance and energy status of anurans from an extremely seasonal semi-arid environment, the Brazillian Caatinga

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