Abstract:With an aggressive medical/surgical approach, even patients with intestinal failure and advanced liver disease can avoid transplantation. Patients in the IRP showed improved liver function and nutritional parameters with the ability to discontinue PN while maintaining growth. Early referral of these patients to specialized centers before the development of advanced liver disease is recommended.
“…This change is likely a result of the improved ability of specialized, interdisciplinary intestine failure units to prevent or resolve intestinal failure associated liver disease (IFALD) which has diminished demand (11,(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). It is unlikely that this change is due to a deficiency in case reporting since (1) a similar trend is documented in the most recent Scientific Registry of Transplant Recipients 2011 Annual Report for the Intestine (http://srtr.transplant.hrsa.…”
“…This change is likely a result of the improved ability of specialized, interdisciplinary intestine failure units to prevent or resolve intestinal failure associated liver disease (IFALD) which has diminished demand (11,(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). It is unlikely that this change is due to a deficiency in case reporting since (1) a similar trend is documented in the most recent Scientific Registry of Transplant Recipients 2011 Annual Report for the Intestine (http://srtr.transplant.hrsa.…”
“…The literature contains several studies on interdisciplinary SBS teams [21][22][23][24][25][26]. The picture emerging from these studies is that such teams have great merits and that early referral is important for successful management [9,21,25,26].…”
“…With institution of multidisciplinary intestinal failure centers 1 and with advances in intestinal transplantation (IT), survival of patients with short bowel syndrome (SBS) improved considerably during the past two decades. 2 Survival after IT now approaches that of other solid organ allograft recipients and is similar to survival on long-term parenteral nutrition (PN).…”
Bowel lengthening is technically feasible and effectively leads to weaning from PN in more than half of the adult patients. Lengthening procedures may be an underutilized treatment for adults with short bowel syndrome.
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