Role of angiotensin and endothelin in testicular ischemia reperfusion injury

Turkili, Burak; Kurçer, Zehra; Dengiz, Günnur Özbakış; Kandemır, Nilüfer Onak; Mungan, Görkem; Özaçmak, Veysel Haktan; Banoğlu, Z. Nur

doi:10.1111/j.1442-2042.2011.02924.x

Cited by 8 publications

(7 citation statements)

References 57 publications

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“…Furthermore, necrosis and degeneration of seminiferous tubule (N) can be noticed in the drug treated groups as shown in Fig 2 : (B and C arrows) as compared with spermatogenesis development which has been noticed on a sample from the control group and numerous spermatozoa are observed within the tubule lumen as observed in Fig 2 (A). These observations agreed with Turkili and others study in 2012 who reported ischemic alterations and maturation arrested in testicular tissue after using Enalapril [14].…”

Section: Resultssupporting

confidence: 93%

The effect of Enalapril drug on some histological aspects of testes tissue in the mature albino male mice

Moosa

Ali

2018

ijs

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The study aimed to evaluate whether Enalapril has any effects on the testicular tissue of the albino male mice which received or did not receive treatment with Enalapril. Mature mice were divided into three groups: control group which fed with 0.1mg of normal saline, the second group was orally fed with 10 mg/Kg of Enalapril drug while the third group was fed with 20 mg/Kg of drug, one time a day for 30 successive days by using gavage tube (0.1ml). The histological sections were performed and the slides were examined using the light microscope. The present study result of light microscopic images of mice testes cross sections which treated with 20 mg/Kg of Enalapril showed coagulated necrosis on spermatogonia germ cells, stopping the maturation in testicular tissue and ischematic alternations. Furthermore, the group treated with 10 mg/Kg showed arresting of spermatozoa maturation, congestion of blood vessels and spreading of edema. In comparison with the control group which demonstrated normal interstitial tissue and absence of edema with spermatogenic maturation observing numerous spermatozoa within the tubule lumen. In conclusion, Enalapril might play a role in pathogenesis of testicular tissue and men infertility.

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Section: Resultssupporting

confidence: 93%

The effect of Enalapril drug on some histological aspects of testes tissue in the mature albino male mice

Moosa

Ali

2018

ijs

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“…In the testes, it has been reported that a local RAS is responsible for maintaining blood pressure and volume (59). During tIR injury, inhibition of the classical RAS pathway leads to reductions in testicular injury, inflammation and oxidative stress (10,60). Recently, the testicular angiotenis converting enzyme (tACE)/Ang-(1-7)/Mas receptor axis has been described and it has been suggested that Ang-(1-7)-mediated protection may increase nitric oxide (NO) bioavailability, inhibit ROS generation and suppress apoptosis in tIR (10).…”

Section: Interaction With Renin-angiotensin System (Ras)mentioning

confidence: 99%

Medical perspective in testicular ischemia-reperfusion injury

Arena

Iacona

Antonuccio

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Testicular torsion or torsion of the spermatic cord is one of the most serious urological conditions. It causes testicular injury, which potentially leads to male subfertility. The turning of the spermatic cord and spermatic structures around themselves results in biochemical and histological changes; however, following testicular detorsion, tissues undergo reperfusion that causes more severe damage than that induced by ischemia. Since the primary causes of testicular damage are reactive oxygen species production, an increase in intra-mitochondrial calcium concentration and an increased rate of cellular apoptosis, different medications may potentially be effective. It seems that several medications, experimentally and sometimes clinically, serve an adjuvant role in the cellular damage that occurs following ischemia-reperfusion. Antioxidants, calcium channel blockers, phytotherapeutical medicinals, anaesthetics, hormones and platelet inhibitors may potentially create a solid basis for an adjuvant restoring therapy and ameliorate testicular function following torsion. The current study aimed to review the relevant literature and discuss the actions of a number of molecules that may protect the testes during ischemia/reperfusion injury.

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“…Even with an immediate untwisting, the resultant damage causes subinfertility and infertility followed by loss of spermatogenesis and germ cell‐specific apoptosis (Mogilner et al ., ; Romero et al ., ; Saeedi Saravi et al ., ). Detrimental mechanism and mediators in testicular torsion/detorsion (T/D) are similar to ischaemia/reperfusion (I/R) injury (Turkili et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Nortriptyline protects testes against germ cell apoptosis and oxidative stress induced by testicular ischaemia/reperfusion

et al. 2016

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We designed this experiment to evaluate the effects of nortriptyline on testicular injury after torsion/detorsion (T/D). Ninety-six adult Wistar rats were divided into six groups 16 each in control group (Group 1), sham operated (Group 2), T/D + saline (Group 3), and in groups 4-6; were administered 2, 10 and 20 mg kg , i.p. of nortriptyline 30 and 90 min after torsion respectively. Testicular torsion was created by twisting the right testis 720° in clockwise direction for 1 h. In six rats of each group, tissue MDA level and caspase-3 activity increased and the activities of catalase, superoxide dismutase and glutathione peroxidase decreased in compared with control group 4 h after detorsion (P < 0.001). In six rats of each group 24 h after detorsion, histopathological changes and germ cell apoptosis were significantly deteriorated by measuring mean of seminiferous tubules diameters (MSTD) and TUNEL test. Moreover, 30 days after T/D, sperm concentration and motility were examined in rest of rats. Pre- and post-reperfusion nortriptyline could reduce MDA and caspase-3 levels and normalise antioxidant enzymes activities, dose dependently. Germ cell apoptosis was significantly decreased, and the MSTD, as well as sperm functions, were significantly improved. Inhibition of mitochondrial permeability transition pore is probably involved in protective effects of nortriptyline against testicular T/D cell damages.

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Role of angiotensin and endothelin in testicular ischemia reperfusion injury

Cited by 8 publications

References 57 publications

The effect of Enalapril drug on some histological aspects of testes tissue in the mature albino male mice

The effect of Enalapril drug on some histological aspects of testes tissue in the mature albino male mice

Medical perspective in testicular ischemia-reperfusion injury

Nortriptyline protects testes against germ cell apoptosis and oxidative stress induced by testicular ischaemia/reperfusion

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