2021
DOI: 10.15789/1563-0625-roa-2342
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Role of antimicrobial peptide DEFB126 mutation in pathogenesis of male idiopathic infertility

Abstract: Male infertility is a multifactorial disease, and elucidation of etiopathogenetic mechanisms of its progression is a topical issue. High percentage of the “idiopathic infertility” diagnosis is largely cased by inability to establish etiology of decrease in reproductive spermatic function. Mutation of в-defensin DEFB126 gene is supposed to affect the fertilizing ability of spermatozoa at different levels: it may decrease their ability to migrate through the cervical mucus and reduce binding capacity to epitheli… Show more

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