Role of antioxidant enzymes in brain tumours

Glutathione peroxidase, glutathione reductase and protein oxidation in patients with glioblastoma multiforme and transitional meningioma

“…However, GPx activity increased prominently in meningiomas, but not in gliomas. Rao et al (2000) studied erythrocyte AOEs in 100 patients with a variety of brain tumors and in 47 healthy controls. SOD, CT and GRx activities showed a highly signiWcant decrease in all types of brain tumors when compared to the controls.…”

“…Altered activity of GPx has also been demonstrated in various types of cancers (Punnonen et al 1994;Wasowicz et al 1994). However; little information is available in the literature in relation to brain cancers (Rao et al 2000;Pu et al 1996;Dudek et al 2002a, b;Yilmaz et al 2006). Furthermore, much has been written about the SODs and CTs in malignant cells and tumors during the last few years.…”

Comparative toxicological evaluation of two medicinal plants used by folklore practitioners of northeast India for treatment of hypertension

“…SOD catalase and GPx along with glutathione reductase (GRx) constitute a supportive team of enzymes, which provide defense against reactive oxygen species (Rao et al 2000). The administration of isoniazid to rats decreased the activity of SOD suggesting that isoniazid might impair central nervous system functions through induction of oxidative stress (Adebayo et al 2012).…”

Susceptibility of peripheral lymphocytes of brain tumour patients to in vitro radiation-induced DNA damage, a preliminary study

“…Effect of radiation is mediated through the generation of free radicals [11] and the resultant damage is directly related to the antioxidant status of the cell. Earlier studies have shown that the level of key antioxidant enzymes, such as superoxide dismutase, catalase, glutathione peroxidase and ceruloplasmin, and antioxidant molecules like glutathione are at a significantly lower level in brain tumour, oral leukoplakia and oral squamous cell carcinoma patients [8,[12][13][14][15].…”