Role of Antioxidants and Natural Products in Inflammation

Arulselvan, Palanisamy; Fard, Masoumeh Tangestani; Tan, Woan Sean; Gothai, Sivapragasam; Fakurazi, Sharida; Norhaizan, Mohd Esa; Kumar, Suresh

doi:10.1155/2016/5276130

Cited by 748 publications

(563 citation statements)

References 92 publications

(110 reference statements)

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“…Inflammation is a process associated with the imbalance of reactive oxygen species/reactive nitrogen species (ROS/RNS) and cellular antioxidants causing oxidative stress and oxidative damage of cellular components (Arulselvan et al, ) in diverse cell types. In addition, many evidences have pointed out that ROS act as a signaling molecule responsible to the gathering of numerous pro‐inflammatory cytokines (e.g., IL‐1β, IL‐6, and TNF‐α) and inducible enzymes involved in free‐radical generation (e.g., iNOS and COX‐2) (Blaser, Dostert, Mak, & Brenner, ).…”

Section: Discussionmentioning

confidence: 99%

“…The anti-mutagenicity possibly associated with rosmarinic acid was present in both in PSE and PSME. Vattem et al (2006) demonstrated that the anti-mutagenic properties of rosmarinic acid in S. typhimurium system occurred through the protection of DNA from oxidative damage, by altering the cellular Inflammation is a process associated with the imbalance of reactive oxygen species/reactive nitrogen species (ROS/RNS) and cellular antioxidants causing oxidative stress and oxidative damage of cellular components (Arulselvan et al, 2016) in diverse cell types. In addition, many evidences have pointed out that ROS act as a signaling molecule responsible to the gathering of numerous pro-inflammatory cytokines (e.g., IL-1b, IL-6, and TNF-a) and inducible enzymes involved in freeradical generation (e.g., iNOS and COX-2) (Blaser, Dostert, Mak, & Brenner, 2016).…”

Section: Effect Of Pse and Psme On Inos And Cox-2 Mrna Expressionmentioning

confidence: 99%

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Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal

et al. 2018

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The objective of this study was to investigate the in vitro bioactivities associated with the content of phytochemicals in the extracts from perilla seed meal extract (PSME) compared with dietary seed (PSE). PSE had higher total phenolics and flavonoids content than PSME. However, hydrophilic phytochemical contents in PSME were quantitatively equivalent to PSE. Rosmarinic acid was predominantly found in both extracts. Cell viability and anti‐mutagenicity testing demonstrated that PSE and PSME were biosecured and non‐genotoxic. Both extracts strongly scavenged free radicals and significantly reduced reactive oxygen species (ROS) production. The extracts drastically diminished nitric oxide (NO) production of LPS‐treated RAW 264.7 cells via iNOS mRNA expression. The expression of IL‐6 and COX‐2 were evidently inhibited by these extracts. It could be concluded that PSE and PSME clearly showed in vitro anti‐mutagenicity, antioxidant and anti‐inflammatory capacities. In particular, the by‐product perilla seed meal could be considered as a high nutritive functional food. Practical applications This study suggests that the seed meals, a by‐product from seed oil industry, can be utilized as a valuable dietary source for humans and animals. The high content of polyphenols and their bioactivities can be developed as functional foods, and excipients and fillers in pharmaceuticals and nutraceuticals production. Moreover, recycling of the by‐product seed meals should also reduce environmental and sanitary pollution.

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Section: Discussionmentioning

confidence: 99%

Section: Effect Of Pse and Psme On Inos And Cox-2 Mrna Expressionmentioning

confidence: 99%

Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal

et al. 2018

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“…A recent investigation suggested that there is an inverse relationship between dietary consumption of antioxidant-rich foods and prevalence of human illness (Arulselvan et al ., 2016). Therefore, in our opinion, incorporation of antioxidant – anti-inflammatory natural product compounds – either in the daily diet or as supplemental medicine, can be a promising and safe solution to solve human health issues, in particular chronic disorders, once their chemical properties are defined and pharmacological effects are elucidated.…”

Section: Introductionmentioning

confidence: 99%

Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

Xiao¹,

Ding²,

Fernandez³

et al. 2017

eCM

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Current non-surgical treatments for lumbar radiculopathy [e.g. epidural steroids and Tumour necrosis factor-α (TNF-α) antagonists] are neither effective nor safe. As a non-toxic natural product, curcumin possesses an exceptional anti-inflammatory profile. We hypothesised that curcumin alleviates lumbar radiculopathy by attenuating neuroinflammation, oxidative stress and nociceptive factors. In a dorsal root ganglion (DRG) culture, curcumin effectively inhibited TNF-α-induced neuroinflammation, in a dose-dependent manner, as shown by mRNA and protein expression of IL-6 and COX-2. Such effects might be mediated via protein kinase B (AKT) and extracellular signal regulated kinase (ERK) pathways. Also, a similar effect in combating TNF-α-induced neuroinflammation was observed in isolated primary neurons. In addition, curcumin protected neurons from TNF-α-triggered excessive reactive oxygen species (ROS) production and cellular apoptosis and, accordingly, promoted mRNA expression of the anti-oxidative enzymes haem oxygenase-1, catalase and superoxide dismutase-2. Intriguingly, electronic von Frey test suggested that intraperitoneal injection of curcumin significantly abolished ipsilateral hyperalgesia secondary to disc herniation in mice, for up to 2 weeks post-surgery. Such in vivo pain alleviation could be attributed to the suppression, observed in DRG explant culture, of TNF-α-elicited neuropeptides, such as substance P and calcitonin gene-related peptide. Surprisingly, micro-computed tomography (µCT) data suggested that curcumin treatment could promote disc height recovery following disc herniation. Alcian blue/picrosirius red staining confirmed that systemic curcumin administration promoted regeneration of extracellular matrix proteins, visualised by presence of abundant newly-formed collagen and proteoglycan content in herniated disc. Our study provided pre-clinical evidence for expediting this natural, non-toxic pleiotropic agent to become a new and safe clinical treatment of radiculopathy.

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“…Free from harmful side effects, adequate intake of natural AOC from foodstuff -mainly flavonoids and other phenolic compounds -was identified as a cheap and suitable means to counter both acute and chronic inflammations and prevent -and sometimes help treatingconsequent acute and chronic illnesses such as neurodegenerative diseases, cancer, diabetes, rheumatoid arthritis, inflammatory bowel disease and cardiovascular diseases (Arulselvan et al, 2016;Pérez-Cano and Castell, 2016;Vezza et al, 2016).…”

Section: Healthier Diets Mattermentioning

confidence: 99%

Innovative beer-brewing of typical, old and healthy wheat varieties to boost their spreading

Albanese

Ciriminna

Meneguzzo

et al. 2017

Preprint

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Certain typical old wheat varieties grown in the Mediterranean countries and elsewhere are renowned for their nutritional value due to higher concentration of polyphenols, especially flavonoids, as well as of important minerals, than modern varieties. However, the respective economical sustainability is constrained by reduced yield, increasing costs and stagnating or decreasing market prices. Moreover, under certain conditions, connected with the respective scale and local market volume, low-input, organically grown cereals can lead to lower environmental footprint. Brewing with a portion of such old grains can effectively boost their spreading, conditioned on its ability to supply a significant additional net income to farmers. Beer has become the worldwide most consumed alcoholic beverage and, although its market is dominated by few global players and standardized products, craft breweries have quickly spread out in most countries. Nevertheless, a scale issue has arisen about the economic sustainability of microbreweries, mainly due to high initial capital investment, energy costs, scale, and sometimes taxation. It is shown how breakthrough, cheaper, more efficient and profitable microbreweries can help solving the sustainability issues affecting old wheat varieties, thus boosting the respective spreading, lowering the environmental footprint of the cereal sector and contributing to improve the public health.

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Role of Antioxidants and Natural Products in Inflammation

Cited by 748 publications

References 92 publications

Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal

Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal

Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

Innovative beer-brewing of typical, old and healthy wheat varieties to boost their spreading

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