Role of antioxidants in fertility preservation of sperm — A narrative review

Qamar, Ahmed Yar; Naveed, Muhammad Ilyas; Raza, Sanan; Fang, Xun; Roy, Pantu Kumar; Bang, Seonggyu; Tanga, Bereket Molla; Saadeldin, Islam M.; Lee, Sanghoon; Cho, Jongki

doi:10.5713/ab.22.0325

Cited by 30 publications

(17 citation statements)

References 147 publications

(148 reference statements)

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“…Spermatozoa with weak and disrupted plasma membrane produce more ROS under stress (Aitken, 2017) [13] . The diet regulates the secretory activity of accessory sex gland thus maintains the antioxidative level of seminal plasma that have a protective role in ROS regulation (Qamar et al, 2023) [14] . The diet offered individually to the buck in pans might have offered the better availability of micro and macro nutrient in required proportion to maintain the reproductive health, thus regulating ROS level in post thaw semen leading to lower value for ROS+ve spermatozoa in group II.…”

Section: Resultsmentioning

confidence: 99%

Effect of group feeding and individual feeding on the post thaw semen quality in breeding Buck

Anand¹,

Yadav²,

Dahariya³

et al. 2023

Int. J. Vet. Sci. Anim. Husbandry

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A study was conducted to evaluate the effect of group feeding and individual feeding on post thaw semen quality in breeding bucks. A total of 16 health breeding buck maintained at goat frozen semen station DUVASU, Mathura were selected for the experiment. After the initial evaluation of semen quality, the bucks were divided into 2 group. In group 1 bucks were kept in together in a shed while in group II every buck was kept in separate pan and feed individually for 90 days. Thereafter semen was collected from each individual buck from both the groups and semen collected from buck of each group was pooled together to reduce the individual variation. The pooled semen was cryopreserved and later analysed. The result exhibited a significantly (p ≤ 0.01) higher values for viability, mitochondrial potential, motility and path velocity and kinematic character in group II compared to group I. The values for viable ROS +ve spermatozoa and those with damaged acrosome were significantly (p ≤ 0.01) higher in group I. The result of study indicate that the breeding bucks maintained at semen station for frozen semen production should be kept and feed in individual pan.

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Section: Resultsmentioning

confidence: 99%

Effect of group feeding and individual feeding on the post thaw semen quality in breeding Buck

Anand¹,

Yadav²,

Dahariya³

et al. 2023

Int. J. Vet. Sci. Anim. Husbandry

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“…During cryopreservation, an increase in free radicals leads to oxidative stress, which leads to structural and functional changes and finally apoptosis. Myo-inositol improves sperm quality, reduces ROS production, protects acrosome integrity and mitochondrial function, protects against cryodamage, and reduces apoptosis [ 40 , 41 , 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Effects of Myo-Inositol Improve the Function and Fertility of Cryopreserved Boar Semen

Osman,

Lee,

Almubarak

et al. 2023

Antioxidants

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During cryopreservation, sperm undergoes structural and molecular changes such as ice crystal formation, DNA fragmentation, and reactive oxygen species (ROS) production, leading to decreased sperm quality after thawing. Antioxidants play a crucial role in preventing these damages, both in vivo and in vitro. One potent antioxidant is myo-inositol, known for its protective effects on sperm against ROS. This study aimed to investigate the protective effect of myo-inositol on cryopreserved boar semen. The semen was diluted, cooled, and cryopreserved using a BF5 extender. It was then divided into five groups: control and different concentrations of myo-inositol (0.5, 1, 1.5, and 2 mg/mL). The post-thaw evaluation included assessments of motility, viability, acrosome integrity, mitochondrial membrane potential (MMP), caspase activity, gene expression, ROS levels, apoptosis, and IVF with treated semen. Results showed that myo-inositol at 0.5 mg/mL improved motility, acrosome integrity, and fertilization ability. It also reduced the expression of pro-apoptotic genes and increased SMCP expression. Lower concentrations also demonstrated improved viability and reduced apoptosis and ROS levels. In conclusion, myo-inositol treatment during cryopreservation improved sperm quality, reduced apoptosis and ROS levels, and enhanced fertility rates in boar semen.

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“…In recent times, there has been significant research conducted on natural antioxidants due to their exceptional ability to counteract oxidative stress [ 6 , 7 ]. Hydroxytyrosol (HT) is a naturally occurring phenolic compound ([2-(3,4-dihydroxyphenyl) ethanol]) that exhibits potent scavengers of hydroxyl radicals (OH ∗ ), peroxynitrite (ONOOH), and superoxide radicals (O(2) ∗ (−)), specifically known as a ROS scavenger.…”

Section: Introductionmentioning

confidence: 99%

Impact of the Antioxidant Hydroxytyrosol on the Quality of Post-Thawed Stallion Semen

Alharbi,

Ali,

Alharbi

2024

Veterinary Medicine International

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The objective of this study was to investigate the impact of including hydroxytyrosol (HT) antioxidant on the viability of sperm after the processes of cooling and freezing. HT antioxidants were used in the HF-20 extender at concentrations of 1.25, 2.5, 5, and 10 μg/ml. The HF-20 extender was a basic extender and was used for the control group. The post-thawed semen exhibited significantly higher total motility in the 2.5 HT and 10 HT treatment groups than the control group. The straight line velocity (VSL) of the 2.5 HT group exhibited a significantly high value compared with the control group. However, the average path velocity (VAP), linearity (LIN), straightness index (STR), and wobble (WOB) revealed identical findings across all groups. The findings of the analysis of HOST, normal morphology, major abnormalities, and minor abnormalities revealed that there were no significant differences between the HT groups and the control groups. Nevertheless, the use of HT antioxidant for freezing semen led to a notable enhancement (p<0.05) in both acrosome integrity and vitality tests when compared to the control group. In this case, the lower quantities of HT (1.25 and 2.5 μg/ml; p<0.05) preserve the DNA fragmentation compared with the 5 HT, 10 HT, and control groups. In conclusion, the HT antioxidant has shown the capacity to enhance the quality of frozen-thawed spermatozoa and positively influence the viability and integrity of DNA inside the frozen-thawed spermatozoa. Additional research should be conducted to assess the fertility potential of cryopreserved stallion semen.

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Role of antioxidants in fertility preservation of sperm — A narrative review

Cited by 30 publications

References 147 publications

Effect of group feeding and individual feeding on the post thaw semen quality in breeding Buck

Effect of group feeding and individual feeding on the post thaw semen quality in breeding Buck

Antioxidant Effects of Myo-Inositol Improve the Function and Fertility of Cryopreserved Boar Semen

Impact of the Antioxidant Hydroxytyrosol on the Quality of Post-Thawed Stallion Semen

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