Role of antiseptics in the prevention and treatment of infections in nursing homes

Alves, Paulo; Gryson, Luc; Hajjar, Joseph; Lepelletier, Didier; Reners, M.; Salazar, J. Rodríguez; Simon, Anne

doi:10.1016/j.jhin.2022.09.021

Cited by 5 publications

(4 citation statements)

References 136 publications

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“…Only one paper compared cadexomer iodine ointment with PVI, recommending cadexomer especially for chronic wound care with increased exudate [15]. Other three papers evaluate antiseptics roles, including PVI, in wound management in different contexts such as European guidelines, critical colonization and/or biofilm and nursing homes [2,16,17]. There were only two systematic reviews on clinical trials regarding antiseptics in chronic wounds management [18,19].…”

Section: Resultsmentioning

confidence: 99%

“…Our literature search, identify 6 reviews on antiseptics that also included PVI, out of which 3 proposed it in wound care. Alves et al recommend PVI in chronic wound management and also propose a practical algorithm in conjunction with mechanically wash and debridement if necessary [16,17]. In contrast, Babalska et al, although one of the antiseptics to consider in wound care, argues against PVI in chronic wounds, due to cytotoxicity and lack of synergy with silver dressings [2].…”

Section: Percutaneous Irrigation and Compression Therapymentioning

confidence: 99%

See 1 more Smart Citation

An Up-to-Date on Povidone-Iodine With Focus on Wound Management: Current Available Data and New Approaches

CHELMUȘ-BURLACU

2023

FARMACIA

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Wound care, mainly chronic wounds and burns with difficult bioburden control and at high risk of infection or biofilm development, remains a challenge. Between antiseptics, as a good option for wound management, povidone-iodine (PVI) is one of the most commonly used. Although with a broad spectrum and efficacy including on biofilms, the available data is controversial, especially regarding its effects on wound healing. Thus, the aim of this paper was to evaluate recent publish data, including original research papers and case reports. Literature search was conducted in PubMed, using a key terms strategy for papers published from 2021 up to present. Out of 101 results, based on inclusion and exclusion criteria, 24 papers were selected for in depth analysis and divided in three categories: reviews, original research and case reports. Out of the selected papers, 6 (25%) were reviews, including two systematic reviews on clinical trials and 3 (12.5%) case reports, out which one reported a significant adverse effect. A total of 15 (62.5%) original research papers were included, that reported heterogeneous results in regards with povidone-iodine effects but similar antimicrobial efficacy. The recent data is focused on comparing antiseptics, including PVI, and proposing algorithms for wound management. Although there is heterogeneity between experimental designs, there is a shift towards more complex models. Thus, is emphasising the need for standardized antiseptic tests and clinical guidelines. RezumatTratamentul plăgilor continuă să fie o provocare, mai ales în cazul celor cronice și al arsurilor, unde controlul încărcăturii microbiene este dificil de obținut, iar riscul de a dezvolta infecții este ridicat. Iod povidona (PVI) este cel mai frecvent antiseptic folosit pentru tratarea plăgilor. Deși are un spectru larg de acțiune, cu eficacitate inclusiv în cazul biofilmelor, datele actuale sunt contradictorii, în special cu privire la impactul asupra procesului de vindecare. Prin urmare, scopul prezentei lucrări a fost evaluarea ultimelor date publicate pe acest subiect. A fost efectuat un studiu de literatură în baza de date PubMed, folosind o combinație de termeni în limba engleză pentru a identifica publicațiile din 2021 până în prezent. Din 101 rezultate generate, au fost selectate, folosind criterii de includere și excludere, 24 de publicații care ulterior au fost împărțite în trei categorii: reviewuri, articole originale de cercetare și raportări de cazuri. Publicațiile selectate, 6 (25%) au fost review-uri, dintre care două review-uri sistematizate despre studii clinice și 3 (12,5%) cazuri raportate, dintre care raportarea unui efect advers semnificativ. Un total de 15 (62,5%) publicații originale din domeniul cercetării incluse, raportează rezultate heterogene cu privire la efectele toxice ale iod-povidonei, deși eficiența antimicrobiană este similară. Datele recente pun accent pe compararea eficacității antisepticelor, inclusiv a iod-povidonei și propun algoritmi pentru utilizarea lor în tratamentul plăgilor. De...

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Section: Resultsmentioning

confidence: 99%

Section: Percutaneous Irrigation and Compression Therapymentioning

confidence: 99%

An Up-to-Date on Povidone-Iodine With Focus on Wound Management: Current Available Data and New Approaches

CHELMUȘ-BURLACU

2023

FARMACIA

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“… 24 The findings of this study highlight that the combination of PV-I with another modality for chronic wounds has improved antibacterial, anti-biofilm, and anti-inflammatory properties. 41 , 42 …”

Section: Discussionmentioning

confidence: 99%

Uncovering the Benefits of Povidone Iodine Compared to Other Therapeutic Agents in Wound Infection Prevention and Healing Outcomes: A Scoping Review

Harun,

Haroen,

Mirwanti

et al. 2024

JMDH

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Background The selection of an appropriate chemical solution in wound care reduces the severity of wounds and accelerates the healing process. Povidone-iodine (PV-I), a chemical solution popularly known as an antiseptic, is frequently used in studies of wound care to prevent wound infection and accelerate woud the process of wound healing. Objective To identify the latest evidence on the benefits of PV-I in wound infection prevention and healing in all areas. Methods This review is a scoping review by Arskey and O’Malley and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) is used for reporting. The literature search used databases including PubMed, CINAHL, and search engines such as Scopus. This study was conducted using thematic analysis. Results This review yielded 19 out of 2109 studies that were identified in the initial search. Four outcomes comprised 20 sub-outcomes have been identified. Although strong evidence is lacking, PV-I in the form of foam is effective in improving wound healing, shortening healing time, and producing fewer adverse events than hydrocelluers. Moreover, saline and PV-I are effective as skin disinfectants when compared to saline alone in reducing surgical site infection (SSI), and they are also more effective than hypochlorous acid in improving wound healing. Nevertheless, there was no difference between PV-I and hypochlorous acid in the prevention of SSI and bacterial growth. In terms of healing time, silver foam and hyaluronic acid were more favorable than PV-I. Moreover, the use of chlorhexidine to improve SSI and silver dressing to improve hospital stay is more favorable than that of PV-I. Conclusion There is limited evidence regarding the effectiveness of wound care outcomes, and the efficacy of PV-I as a surface disinfectant for wound infection prevention remains controversial. Consequently, PV-I is not highly recommended for wound care, and further investigation into the effectiveness of PV-I as a surface disinfectant is required for various types of surgeries.

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“…This COVID-19 mouth washing protocol lasts longer than the daily routine for most patients and may have unexpected benefits in reducing oral microbes as a result [ 15 ]. For example, there is some evidence that povidone–iodine antiseptics are effective in reducing common oropharyngeal infections, including those caused by gram-positive organisms such as Staphylococcus aureus [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of SARS-CoV-2 (COVID-19) Clinical Mouthwash Protocol and Prevalence of the Oral Pathogen Scardovia wiggsiae: A Pilot Study of Antibacterial Effects

Shayegh,

Sorenson,

Downey

et al. 2023

MPs

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One protocol in healthcare facilities and dental offices due to the COVID-19 pandemic for reducing the amount of detectable oral SARS-CoV-2 has been gargling with mouthwash for 60 s. This protocol lasts longer than the daily routine for most patients and may have unexpected benefits in reducing oral microbes as a result. This project evaluated the prevalence of the newly identified oral pathogen Scardovia wiggsiae before and after this procedure to determine any measurable effects. Using an approved protocol, n = 36 pre-mouthwash patient samples, n = 36 matched post-mouthwash samples, and n = 36 matched recall samples were identified (total sample number n = 108). DNA was isolated from each sample (pre-, post-mouthwash, and recall). Screening using qPCR and validated primers revealed n = 10/36 or 27.8% tested positive for Scardovia among the pre-mouthwash (Sample A) isolates with n = 3/36 or 8.3% testing positive among the post-mouthwash (Sample B) isolates. Screening of the recall (Sample C) samples has revealed n = 10/36, or 27.8% once again tested positive for Scardovia, demonstrating that this pathogen was found among a significant proportion of pediatric patient samples. Moreover, the COVID-19-related procedure of requiring sustained mouth washing prior to clinical treatment appears to reduce the levels of detectable Scardovia, at least initially. However, this study found no long-term effects using this isolated protocol.

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Role of antiseptics in the prevention and treatment of infections in nursing homes

Cited by 5 publications

References 136 publications

An Up-to-Date on Povidone-Iodine With Focus on Wound Management: Current Available Data and New Approaches

An Up-to-Date on Povidone-Iodine With Focus on Wound Management: Current Available Data and New Approaches

Uncovering the Benefits of Povidone Iodine Compared to Other Therapeutic Agents in Wound Infection Prevention and Healing Outcomes: A Scoping Review

Assessment of SARS-CoV-2 (COVID-19) Clinical Mouthwash Protocol and Prevalence of the Oral Pathogen Scardovia wiggsiae: A Pilot Study of Antibacterial Effects

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