Role of apolipoproteins in the pathogenesis of obesity

Huang, Mingjing; Zheng, Jiang Yu; Chen, Lijun; You, Sufang; Huang, Huibin

doi:10.1016/j.cca.2023.117359

Cited by 5 publications

(2 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We did not find significant associations with underweight, which was most likely caused by the low sample size and hence lower statistical power. Similar to previous studies 115 , we detected an association of apolipoproteins D and M levels with elevated BMI. We also report novel protein associations with BMI including Apolipoprotein C2 (APOC2) and fibulin 1 (FBLN1), when corrected for metabolic disorders such as T2DM and metS.…”

Section: Discussionsupporting

confidence: 91%

Menopause Hormone Replacement Therapy and Lifestyle Factors affect Metabolism and Immune System in the Serum Proteome of Aging Individuals

Dierks,

Mizrak,

Shomroni

et al. 2024

Preprint

View full text Add to dashboard Cite

Aging is a fundamental risk factor for a wide array of diseases. The Berlin Aging Study II (BASE-II) is a cohort study designed to investigate the physical, mental, and social determinants of successful aging. We utilized high-throughput mass spectrometry to measure the proteomes of 1890 BASE-II participants, divided into two age groups: 27-37 years and 60-85 years. We employed multiple linear regression analyses to explore the effects of demographic factors such as age, sex, and BMI, along with hormonal treatments and lifestyle factors, on the serum proteome. We identify new associations and confirm previously described proteins linked to age, sex, BMI and hormonal contraceptive use (HCU). Notably, we observed that the abundance of nutrient transport proteins, particularly apolipoproteins, is linked to metabolic diseases in aged individuals, including metabolic syndrome and type 2 diabetes. Additionally, we identified specific alterations explained by lifestyle factors, such as smoking and alcohol consumption. We further report a significant proteome signature in female study participants corresponding to menopause hormone replacement therapy (MHT). We successfully classified these participants based on MHT status with an AUROC of 0.82 using two proteins, Complement Component 9 and Plasminogen, slightly outperforming estradiol (AUROC: 0.80), the active ingredient in most MHT preparations. Overall, our study underscores the impact of lifestyle and hormonal therapies on the serum proteome during aging, primarily affecting components of the immune system and metabolism.

show abstract

Section: Discussionsupporting

confidence: 91%

Menopause Hormone Replacement Therapy and Lifestyle Factors affect Metabolism and Immune System in the Serum Proteome of Aging Individuals

Dierks,

Mizrak,

Shomroni

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…For instance, LDH and LDH1 were associated with multiple genes/proteins, including APOH, APOA4, APOC3, APOA2, and partial lncRNAs. LDH is a crucial enzyme involved in the anaerobic glycolysis process [ 60 ], while apolipoprotein is a key component of plasma lipoprotein that plays a role in various processes such as inflammation inhibition, oxidative stress prevention, tissue remodeling, lipid metabolism, energy consumption, and more [ 61 , 62 ]. As altitude increased, the environment’s PO 2 decreased, leading to an increased proportion of glycolysis in animal organisms and a higher likelihood of lipid metabolism and inflammation.…”

Section: Discussionmentioning

confidence: 99%

LncRNA and Protein Expression Profiles Reveal Heart Adaptation to High-Altitude Hypoxia in Tibetan Sheep

He,

Li,

Zhao

et al. 2023

IJMS

View full text Add to dashboard Cite

The Tibetan sheep has an intricate mechanism of adaptation to low oxygen levels, which is influenced by both genetic and environmental factors. The heart plays a crucial role in the adaptation of Tibetan sheep to hypoxia. In the present study, we utilized transcriptomic and proteomic technologies to comprehensively analyze and identify the long non-coding RNAs (lncRNAs), genes, proteins, pathways, and gene ontology (GO) terms associated with hypoxic adaptation in Tibetan sheep at three different altitudes (2500 m, 3500 m, and 4500 m). By integrating the differentially expressed (DE) lncRNA target genes, differentially expressed proteins (DEPs), and differentially expressed genes (DEGs), we were able to identify and characterize the mechanisms underlying hypoxic adaptation in Tibetan sheep. Through this integration, we identified 41 shared genes/proteins, and functional enrichment analyses revealed their close association with lipid metabolism, glycolysis/gluconeogenesis, and angiogenesis. Additionally, significant enrichment was observed in important pathways such as the PPAR signaling pathway, glycolysis/gluconeogenesis, the oxoacid metabolic process, and angiogenesis. Furthermore, the co-expression network of lncRNAs and mRNAs demonstrated that lncRNAs (MSTRG.4748.1, ENSOART00020025894, and ENSOART00020036371) may play a pivotal role in the adaptation of Tibetan sheep to the hypoxic conditions of the plateau. In conclusion, this study expands the existing database of lncRNAs and proteins in Tibetan sheep, and these findings may serve as a reference for the prevention of altitude sickness in humans.

show abstract

Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome

Zhang,

Cheng,

Hong

et al. 2023

Mol Biomed

View full text Add to dashboard Cite

Obesity is a metabolic disorder characterized by the hypertrophy expansion of adipose tissue, resulting in dysregulated energy metabolism, and accompanied by chronic low-grade inflammation. Adipose tissue macrophages (ATMs), a principal component of inflammation, respond to microenvironment signals and modulate adipose tissue remodeling and metabolic processes situation-specific. However, the mechanisms governing how the organism maintains equilibrium between its chronic inflammation and metabolism still need to be understood. Here, we describe a novel role of apolipoprotein E (ApoE), which associated with lipid particles, in maintaining fat deposition and system metabolic inflammation. Using human samples and mouse models, we show that ApoE is robustly downregulated in obese individuals, db/db mice, and mice of high-fat diet (HFD) feeding and increased in obese subjects with diabetes. Furthermore, we found that ApoE deficiency mice globally prevented obesity by restraining adipose tissue expansion and improved systemic glucose tolerance and insulin sensitivity. However, macrophage contributed to metabolic inflammation due to increased IL-1β production in adipose tissue from ApoE-/- mice induced by HFD. Our results suggest that the role of ApoE in regulating obesity and obesity-associated glucose dysregulation is inconsistent. Mechanistically, ApoE modulates of the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome priming and activation step. Thus, our studies might provide new sights into ApoE, which is required for obesity-induced hyperglycemia, hyperinsulinism, and adaptive inflammation responses but diminishes the tolerance towards a subsequent metabolic inflammatory challenge. Our study shed new light on the integral role of apolipoprotein APOE in immunometabolism and adipose tissue homeostasis.

show abstract

Role of apolipoproteins in the pathogenesis of obesity

Cited by 5 publications

References 100 publications

Menopause Hormone Replacement Therapy and Lifestyle Factors affect Metabolism and Immune System in the Serum Proteome of Aging Individuals

Menopause Hormone Replacement Therapy and Lifestyle Factors affect Metabolism and Immune System in the Serum Proteome of Aging Individuals

LncRNA and Protein Expression Profiles Reveal Heart Adaptation to High-Altitude Hypoxia in Tibetan Sheep

Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome

Contact Info

Product

Resources

About