2010
DOI: 10.1186/1471-2121-11-13
|View full text |Cite
|
Sign up to set email alerts
|

Role of apoptosis-inducing factor (AIF) in programmed nuclear death during conjugation in Tetrahymena thermophila

Abstract: BackgroundProgrammed nuclear death (PND), which is also referred to as nuclear apoptosis, is a remarkable process that occurs in ciliates during sexual reproduction (conjugation). In Tetrahymena thermophila, when the new macronucleus differentiates, the parental macronucleus is selectively eliminated from the cytoplasm of the progeny, concomitant with apoptotic nuclear events. However, the molecular mechanisms underlying these events are not well understood. The parental macronucleus is engulfed by a large aut… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
51
0

Year Published

2011
2011
2022
2022

Publication Types

Select...
5
2
1

Relationship

0
8

Authors

Journals

citations
Cited by 42 publications
(53 citation statements)
references
References 40 publications
2
51
0
Order By: Relevance
“…It divides twice mitotically to give rise to precursors for two new macronuclei, one new micronucleus, and a fourth nucleus that degenerates. During this time, the old macronucleus goes through a degenerating process that involves genes related to apoptosis (8) and autophagy (9). The mating pair separates and rests in this state with two new macronuclei and one new micronucleus per cell ("2 MAC 1 MIC").…”
Section: Tetrahymena Life Cyclementioning
confidence: 99%
“…It divides twice mitotically to give rise to precursors for two new macronuclei, one new micronucleus, and a fourth nucleus that degenerates. During this time, the old macronucleus goes through a degenerating process that involves genes related to apoptosis (8) and autophagy (9). The mating pair separates and rests in this state with two new macronuclei and one new micronucleus per cell ("2 MAC 1 MIC").…”
Section: Tetrahymena Life Cyclementioning
confidence: 99%
“…It shares a highly significant homology with different families of oxydoreductases, from Archaea and Bacteria to invertebrates and vertebrates (4, 12) ( Table 1). From ciliated protozoan to mammals, AIF loss is associated with growth retardation at different stages of animal development (14)(15)(16)(17). Therefore, AIF is an important element of the apoptotic machinery that follows the rules of standard evolution (25).…”
Section: Aif Across the Speciesmentioning
confidence: 99%
“…Another apoptotic mitochondrial protein, AIF, is also involved in Tetrahymena PND. Knocking out the AIF gene in MAC caused a four hour delay in DNA fragmentation, but did not completely inhibit the PND (Akematsu & Endoh, 2010). Recently, we have detected increasing acidic DNase activity during late PND, implying a possible role for lysosomal DNase II (Aslan & Arslanyolu, 2015).…”
Section: Introductionmentioning
confidence: 98%
“…PND has been studied mostly with Tetrahymena (Akematsu, Pearlman & Endoh, 2010; Akematsu & Endoh, 2010; Akematsu et al, 2014), and molecular mechanisms of PND in other ciliates remain elusive. PND in Tetrahymena shares some phenotypic and biochemical resemblance to apoptosis or programmed cell death (PCD) in higher eukaryotes.…”
Section: Introductionmentioning
confidence: 99%