Role of ascitic fluid C3 in spontaneous bacterial peritonitis

Kamal, Amany Talaat; Osman, Eman Nagib; Shahin, Rasha Y

doi:10.1016/j.ejmhg.2011.10.005

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Activation and consumption of C3 is one factor causing the low AF C3 concentration observed in SBP patients and in agreed with our study [32]. Kamal et al, reported that the reduced levels of AF C3 in SBP patients is mostly a predisposing factor rather than consumption by complement activation due to bacterial infection [33]. Many mechanism were suggested for the lower level of C3 in the AF: dilution, decreased hepatic synthesis of complement and greater consumption of C3 due to activation of the alternative complement pathway [5].…”

Section: Discussionsupporting

confidence: 93%

Value of Different Diagnostic Markers in Spontaneous Bacterial Peritonitis in HCV Egyptian Cirrhotic Patients

Motasem¹,

Heikal²,

Haddad³

et al. 2015

OJGas

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Background: Spontaneous bacterial peritonitis (SBP) is a life-threatening infection occurring in 8% -30% of ascitic cirrhotic patients; different laboratory diagnostics play a pivotal role for rapid and effective management of SBP patients. Polymorphonuclear leucocytic (PMNLs) count in Ascitic fluid (AF) is the mainstay for the diagnosis, whereas the diagnostic role of alternative biomarkers is rather controversial. In many studies, serum lipopolysaccharide binding protein (LBP) was elevated and Complement 3 (C3) level was significantly consumed in AF of SBP patients. Objectives: To evaluate the diagnostic value of serum LBP and AF C3 in HCV-cirrhotics with SBP in relation to other well-established serum and AF markers. Patients and Methods: One hundred and twenty patients with HCV-cirrhosis and ascites were enrolled and consented: 50 patients with non-SBP ascites in group A and 70 ascitic patients diagnosed with SBP according to clinical suspicion and PMLs count in AF ≥ 250 cells/mm 3 in group B in addition to 15 healthy individuals considered as a control group. Serum LBP, CBC, kidney and liver function tests, CRP, fasting and 2 h PP blood glucose and HCV antibodies were measured. AF samples were sent for C3 level, culture, PMNLs count, LDH, CRP, total proteins and albumin. Results: In patients with SBP, the level of serum LBP was not significantly high (p > 0.05) with best cut off value at 0.4500 and poor AUC (<0.6) with low sensitivity and specificity (53. 3% & 57.7%, respectively). AF C3 was significantly reduced in AF (p < 0.001) with best cut off value at 144.2 and almost excellent AUC (0.889) with good sensitivity and specificity (82% & 84%, respectively). AF culture showed significant difference between both patients groups (p < 0.05) but with low sensitivity (33.3%). Serum and AF CRP and AF PMNLs count were of high significance in SBP diagnosis (p < 0.001). Conclusion: Serum LBP level showed low significance while AF C3 was significantly reduced in patients with SBP. AF culture showed significant difference between both groups but with low sensitivity while serum, AF levels of CRP and AF

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Section: Discussionsupporting

confidence: 93%

Value of Different Diagnostic Markers in Spontaneous Bacterial Peritonitis in HCV Egyptian Cirrhotic Patients

Motasem¹,

Heikal²,

Haddad³

et al. 2015

OJGas

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“…However, these results are not in agreement with the fi ndings of Kamal et al [24], who carried out their study on 45 cirrhotic patients; 25 of these patients had SBP. Th ey found a low level of ascitic fl uid C3 in cirrhotic patients with SBP compared with patients without SBP, probably because C3 plays an important role in the local defense of ascitic fl uid.…”

Section: Figurecontrasting

confidence: 74%

Diagnosis of spontaneous bacterial peritonitis

et al. 2014

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“…Talaat et al (20) found that Both the neutrophil count and the lactate dehydrogenase level in the ascitic fluid of patients with spontaneous bacterial peritonitis were significantly greater than those of individuals with cirrhosis of the liver but no peritonitis symptoms (group II) (P-value 0.000 and 0.003, respectively), Patients in Group I had considerably lower levels of total proteins, albumin, and glucose (Pvalue 0.000, 0.028 and 0.021, respectively).…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients

Elhendawy,

Elghoneimy,

Elnemr

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: A serious problem for cirrhotic individuals is spontaneous bacterial peritonitis (SBP). Clinical significance of SBP's C-reactive protein (CRP) as well as neutrophil-to-lymphocyte ratio (NLR) have been discovered using varying threshold levels. Objective: The aim of the current work was to assess the validity of diagnostic paracentesis with the use of combined blood NLR and CRP as a non-invasive predictor for early diagnosis of SBP. Patients and Methods: This case control study included a total of 60 cirrhotic decompensated patients, admitted at

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Role of ascitic fluid C3 in spontaneous bacterial peritonitis

Cited by 3 publications

References 12 publications

Value of Different Diagnostic Markers in Spontaneous Bacterial Peritonitis in HCV Egyptian Cirrhotic Patients

Value of Different Diagnostic Markers in Spontaneous Bacterial Peritonitis in HCV Egyptian Cirrhotic Patients

Diagnosis of spontaneous bacterial peritonitis

Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients

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