Role of Atrial Natriuretic Peptide in Hemoconcentration During Exercise

Tsai, Rong-Chi; Yamaji, Taiki; Ishibashi, Masayoshi; Takaku, Fumimaro; Hsu, Shih-Tien; Yeh, San‐Jou; Lee, Ying-Shiung

doi:10.1093/ajh/3.11.833

Cited by 3 publications

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“…With respect to the CV system, it shifts fluid from the intravascular to the interstitial compartment, resulting in decrease in PV. Studies have implicated ANP in hemoconcentration occurring in exercise and preeclampsia (Poulsen et al., 1993; Tsai et al., 1990). Sodium lactate is another pharmacological agent that can be used experimentally to induce PAs (Peskind et al., 1998).…”

Section: Discussionmentioning

confidence: 99%

Pentagastrin-induced hemoconcentration in healthy volunteers and patients with panic disorder: effect of pretreatment with ethinyl estradiol

Mellédo

Perez-Parada

Morrow³

et al. 2009

J Psychopharmacol

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Panic disorder has been associated with both an increased risk of coronary events as well as an increased risk of stroke. Hemoconcentration, with both a decrease in plasma volume and an increase in plasma viscosity, is a possible contributor to the risk of acute ischemic events. Our objectives were to demonstrate the process of hemoconcentration in response to induced panic symptoms and to assess the effect of pretreatment with ethinyl estradiol on panic-induced hemoconcentration. Fifteen male patients with panic disorder and 10 male healthy volunteers were included in a double-blind cross-over placebo-controlled design consisting of two injections of pentagastrin following randomized pretreatment with placebo and ethinyl estradiol. Plasma levels of hematocrit and hemoglobin were assessed at baseline and post-injections, and used to calculate an indirect estimation of the change in plasma volume. Pentagastrin-induced panic symptoms were associated with a mean decrease in plasma volume of 4.8% in the placebo pretreatment condition. Pretreatment with ethinyl estradiol attenuated this effect. The acute hemoconcentration observed in relation to pentagastrin-induced panic symptoms may be relevant to the increased risk of stroke and acute coronary events found in patients with panic disorder.

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Section: Discussionmentioning

confidence: 99%

Pentagastrin-induced hemoconcentration in healthy volunteers and patients with panic disorder: effect of pretreatment with ethinyl estradiol

Mellédo

Perez-Parada

Morrow³

et al. 2009

J Psychopharmacol

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“…Daha önceki bir çalışmada ANP'nin kan hematokrit düzeyindeki deği-şimde rol oynayan bir faktör olabileceğini bildirmiştir. [16] Bu nedenle grupların hematokrit düzeylerinin benzer olup olmadığı belirlendi.…”

Section: çAlışma Programı Ve öLçümlerunclassified

The Alteration Of Plasma Atrial Natriuretic Peptide Levels Induced By Postural Changes In Archery Athletes

Vardar¹,

Aktöz²,

Karakuşoğlu³

et al. 2009

TUTFD

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Objectives:The aim of this study was to investigate plasma atrial natriuretic peptid levels in sitting and supine positions and cardiac functions in young male archery athletes. Materials and Methods:Six archery athletes and 10 sedentary males volunteered to participate in the study. Venous blood samples were taken after 10 minutes sitting and after 10 minutes in supine position. Plasma ANP levels were measured by the ELISA method. Cardiac parameters were assessed by echocardiography.Results: Plasma ANP levels in sitting position were higher in archery athletes (72.12±14.01 pg/ ml) than sedentaries (36.22±14.51 pg/ml; p<0.01). Similarly, plasma ANP levels in supine position (124.41±14.66 pg/ml) were significantly higher in the athletes than sedentaries (36.95±9.83 pg/ml). Plasma ANP levels were higher in supine position than those in sitting position in archery athletes (p<0.01). No significant increase in plasma ANP levels were found in supine position than sitting position in sedentary group. Echocardiographic parameters were similar in athletes and sedentary subjects. Conclusion:It is concluded that regular archery exercises without prominent functional and morphological alterations in the heart may cause differences in plasma ANP levels. Marked posture-related alterations may occur in plasma ANP levels of trained archery athletes.Key words: Atrial natriuretic peptid; exercise; posture; archery.Amaç: Bu çalışmanın amacı, okçuluk sporu yapan genç erkek sporcuların plazma atriyal natriüretik peptid (ANP) düzeylerinde oturur ve yatar durumdaki değişimi ve kardiyak fonksiyonlarını incelemektir.Gereçler ve Yöntemler: Çalışmaya, gönüllü 6 okçuluk sporcusu ve 10 sedanter erkek katıldı. Katılımcılardan 10 dk'lık oturma sonrası ve 10 dk'lık yatar durumdan sonra venöz kan alındı. Plazma ANP düzeyleri ELISA yöntemi ile ölçüldü. Kardiyak parametreler ekokardiyografi ile belirlendi. Bulgular:Okçuluk sporcularının oturur durumdaki plazma ANP düzeylerinin (72.12±14.01 pg/ml) sedanter grubun oturur durumdaki ANP düzeylerinden (36.22±14.51 pg/ml) yüksek olduğu bulundu (p<0.01). Aynı şekilde okçuluk sporcularının yatar durumdaki ANP düzeyleri de (124.41±14.66 pg/ml) sedanterlere göre (36.95±9.83 pg/ml) anlamlı yükseklik gösterdi (p<0.01). Sporcu grubun plazma ANP düzeyleri oturur duruma göre yatar durumda artmış bulundu (p<0.01). Sedanter grubun ANP düzeylerinde ise oturur duruma göre yatar durumda anlamlı bir artış saptanmadı. Sporcu ve sedanterlerin ekokardiyografik parametreleri benzer bulundu.Sonuç: Çalışmamıza göre okçulukla ilgili yapılan düzenli egzersizler, kalpte belirgin fonksiyonel ve morfolojik değişim olmaksızın, plazma ANP düzeyle-rinde farklılıklara neden olabilir. Okçuluk sporu yapanların plazma ANP düzeyinde postürle ilişkili belirgin farklılıklar oluşabilir.

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The effects of medications on circulating levels of cardiac natriuretic peptides

et al. 2007

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Circulating cardiac natriuretic peptide levels are being used increasingly in a range of clinical circumstances. Since it is evident that drugs used in the treatment of cardiovascular disorders can modulate natriuretic peptide levels, we here review the literature documenting these effects. Diuretics, blockers of the renin-angiotensin system, vasodilator agents, dopamine-like agonists, amiodarone, and perhaps allopurinol and statins suppress natriuretic peptide levels, most obviously in heart failure. Beta-blockers stimulate natriuretic peptide concentrations in hypertensive subjects, whereas in heart failure they have little effect or are stimulatory in the short term and inhibitory with sustained therapy. Digitalis compounds and aspirin tend to increase natriuretic peptide levels, and calcium channel blocking agents have varying effects depending on the individual drug and duration of administration. The effects of other drugs are less clear. Additional information is needed regarding the effects of medications along with dissection of the role of altered cardiac secretion versus changes in plasma clearance as explanation for drug-induced perturbations in natriuretic peptide concentrations. In the meantime, clinicians need to consider the known effects of medications when interpreting plasma levels of the cardiac natriuretic peptides.

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Role of Atrial Natriuretic Peptide in Hemoconcentration During Exercise

Cited by 3 publications

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Pentagastrin-induced hemoconcentration in healthy volunteers and patients with panic disorder: effect of pretreatment with ethinyl estradiol

Pentagastrin-induced hemoconcentration in healthy volunteers and patients with panic disorder: effect of pretreatment with ethinyl estradiol

The Alteration Of Plasma Atrial Natriuretic Peptide Levels Induced By Postural Changes In Archery Athletes

The effects of medications on circulating levels of cardiac natriuretic peptides

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