Role of autonomic nervous system for development and suppression of motion sickness in Suncus murinus

Uchino, Masahiro; Ishii, Kikujiro; Kuwahara, Masayoshi; Ebukuro, Susumu; Tsubone, Hirokazu

doi:10.1016/s1566-0702(01)00344-7

Cited by 15 publications

(8 citation statements)

References 28 publications

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“…Studies investigating the cardiac autonomic nervous system during motion sickness confi rm this fi nding. Uchino et al [ 41 ] reported that sympathetic nervous system dominance suppresses the motion sickness induced emetic response. Accordingly, Rawat et al [ 31 ] found a strong relationship between aerobic fi tness and motion sickness and suggests that the increased vagal tone of aerobically fi t individuals might be responsible for it.…”

Section: Eff Ects Of Hrv On Ams Developmentmentioning

confidence: 99%

Effects of Exercise and Hypoxia on Heart Rate Variability and Acute Mountain Sickness

Mairer

Wille

Grander³

et al. 2013

Int J Sports Med

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Acute mountain sickness (AMS) is a common condition among non-acclimatized individuals ascending to high altitude. Exercise, a characteristic feature of hiking and mountaineering, has been suggested to exacerbate AMS prevalence and to cause modifications of the autonomic nervous system. A reduction of the heart rate variability (HRV) is a common finding during acute hypoxia, however characteristics of HRV during exercise in subjects suffering from AMS are unknown. Therefore, the aim of the present study was to investigate the effects of acute normobaric hypoxia (FiO2=11.0% ≙ 5 500 m) at rest (PHE) and during exercise (AHE) on the cardiac autonomic function and the development of AMS in 20 healthy, male individuals. HRV recordings were performed during normoxia and after 2, 4, 6 and 8 h in hypoxia during PHE and AHE, respectively. AMS was assessed using the Lake Louise Score. During PHE 50% of participants developed AMS and 70% during AHE (p=0.22). The analysis of HRV data showed a significant reduction of total power (TP), high frequency (HF) and low frequency (LF) components and an increase of the LF:HF ratio during PHE, however without further modification during AHE. Exercise did not increase AMS prevalence or severity, but increased "non-gastrointestinal" symptoms including headache, fatigue and dizziness. HRV indices were not related to the overall incidence of AMS or the development of "non-gastrointestinal" symptoms but we detected significant correlations between gastrointestinal complaints and HRV components. Thus, we suggest that the cardiac autonomic modulation during acute normobaric hypoxia does not play an important role in the development of AMS, but seems to be related to gastrointestinal complaints at high altitude. However, the influence of moderate exercise on HRV and AMS is minor, only "non-GI" symptoms seem to be exacerbated when exercise is applied.

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Section: Eff Ects Of Hrv On Ams Developmentmentioning

confidence: 99%

Effects of Exercise and Hypoxia on Heart Rate Variability and Acute Mountain Sickness

Mairer

Wille

Grander³

et al. 2013

Int J Sports Med

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“…Ebukuro et al [3] noted differences in veratrine sensitivity among musk shrews, and strains with high and low sensitivity have been maintained. In recent years, selected strains with such characteristics have been widely used in various experiments and toxic tests [14,15]. However, all these studies have used adult animals, and there are no data from young animals.…”

Section: Introductionmentioning

confidence: 99%

Emetic Responses and Neural Activity in Young Musk Shrews during the Breast-Feeding/Weaning Period: Comparison between the High and Low Emetic Response Strains Using a Shaking Stimulus

et al. 2005

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“…Other investigators have reported selective breeding of musk shrews for veratrine-induced emesis [39], a plant alkaloid toxin believed to act on the vagus nerve [40, 41]. These veratrine-sensitive animals were also subsequently reported to display differential emetic responses to motion exposure [42, 43]; this would indicate that these high and low response animals have a general sensitivity to emetic activation – independent of the type of emetic input. In contrast, the current study suggests that our High and Low strain musk shrews have specific sensitivity to activation of the vestibular system.…”

Section: Discussionmentioning

confidence: 99%

Musk shrews selectively bred for motion sickness display increased anesthesia-induced vomiting

Horn

Meyers

Oberlies

2014

Physiology & Behavior

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Susceptibility to motion sickness is a predictor of postoperative nausea and vomiting, and studies in humans suggest that genetic factors determine sensitivity to motion sickness. The aim of the current study was to determine if a preclinical model could be selectively bred for motion-induced emesis and to assess a potential relationship to anesthesia-induced emesis. Musk shrews were tested for motion-induced emesis using a shaker plate (10 min, 1 Hz, and 4 cm of lateral displacement). Animals were rank ordered for motion-induced emesis and selectively bred to produce high and low response strains. Shrews were also tested with nicotine (5 mg/kg, sc), copper sulfate (CuSO4; 120 mg/kg, ig), and isoflurane anesthesia (10 min; 3%) to determine responses to a panel of emetic stimuli. High response strain shrews demonstrated significantly more emetic responses to motion exposure compared to low response strain animals in the F1 and F2 generations. In F2 animals, there were no significant differences in total emetic responses or emetic latency between strains after nicotine or CuSO4 injection. However, isoflurane exposure stimulated more emesis in F1 and F2 high versus low strain animals, which suggests a relationship between vestibular- and inhalational anesthesia-induced emesis. Overall, these results indicate genetic determinants of motion sickness in a preclinical model and a potential common mechanism for motion sickness and inhalational anesthesia-induced emesis. Future work may include genetic mapping of potential “emetic sensitivity genes” to develop novel therapies or diagnostics for patients with high risk of nausea and vomiting.

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Role of autonomic nervous system for development and suppression of motion sickness in Suncus murinus

Cited by 15 publications

References 28 publications

Effects of Exercise and Hypoxia on Heart Rate Variability and Acute Mountain Sickness

Effects of Exercise and Hypoxia on Heart Rate Variability and Acute Mountain Sickness

Emetic Responses and Neural Activity in Young Musk Shrews during the Breast-Feeding/Weaning Period: Comparison between the High and Low Emetic Response Strains Using a Shaking Stimulus

Musk shrews selectively bred for motion sickness display increased anesthesia-induced vomiting

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