Role of Autophagy and Mitophagy in Neurodegenerative Disorders

Kapil, Lakshay; Kumar, Vishal; Kaur, Simranjit; Sharma, Deepali; Singh, Charan; Singh, Arti

doi:10.2174/1871527322666230327092855

Cited by 2 publications

(1 citation statement)

References 162 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Autophagy, including mitophagy, is a critically important process that facilitates neuronal recovery after TBI [221]. Accordingly, its malfunction is involved in neurodegenerative disease progression [222]. MSCs given to rats with TBI provided neuroprotection by inducing autophagy, mitophagy, and by elevating anti-inflammatory cytokines, such as interleukin-10 (IL-10) [223].…”

Section: Neurological Injury and Msc Mitochondrial Transfer Involvementmentioning

confidence: 99%

Therapeutic Effects of Mesenchymal Stromal Cells Require Mitochondrial Transfer and Quality Control

Mukkala,

Jerkic,

Khan

et al. 2023

IJMS

View full text Add to dashboard Cite

Due to their beneficial effects in an array of diseases, Mesenchymal Stromal Cells (MSCs) have been the focus of intense preclinical research and clinical implementation for decades. MSCs have multilineage differentiation capacity, support hematopoiesis, secrete pro-regenerative factors and exert immunoregulatory functions promoting homeostasis and the resolution of injury/inflammation. The main effects of MSCs include modulation of immune cells (macrophages, neutrophils, and lymphocytes), secretion of antimicrobial peptides, and transfer of mitochondria (Mt) to injured cells. These actions can be enhanced by priming (i.e., licensing) MSCs prior to exposure to deleterious microenvironments. Preclinical evidence suggests that MSCs can exert therapeutic effects in a variety of pathological states, including cardiac, respiratory, hepatic, renal, and neurological diseases. One of the key emerging beneficial actions of MSCs is the improvement of mitochondrial functions in the injured tissues by enhancing mitochondrial quality control (MQC). Recent advances in the understanding of cellular MQC, including mitochondrial biogenesis, mitophagy, fission, and fusion, helped uncover how MSCs enhance these processes. Specifically, MSCs have been suggested to regulate peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC1α)-dependent biogenesis, Parkin-dependent mitophagy, and Mitofusins (Mfn1/2) or Dynamin Related Protein-1 (Drp1)-mediated fission/fusion. In addition, previous studies also verified mitochondrial transfer from MSCs through tunneling nanotubes and via microvesicular transport. Combined, these effects improve mitochondrial functions, thereby contributing to the resolution of injury and inflammation. Thus, uncovering how MSCs affect MQC opens new therapeutic avenues for organ injury, and the transplantation of MSC-derived mitochondria to injured tissues might represent an attractive new therapeutic approach.

show abstract

Section: Neurological Injury and Msc Mitochondrial Transfer Involvementmentioning

confidence: 99%