Role of Ayurvedic Plants as Anticancer Agents

Pandey, Nikhil; Tripathi, Yamini B.

doi:10.1007/978-1-0716-1952-0_14

Cited by 1 publication

(1 citation statement)

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“…As dietary habits diversify these days, research on natural products for cancer prevention is becoming more important, so in this study, the anticancer effect of Cirsium setidens is to be investigated (Pandey & Tripathi, 2022). Cirsium setidens is a perennial herb of the Asteraceae family and has been used as a medicine and food because it is effective for hypertension, antitumor, antioxidant, and hepatoprotective (Shin et al, 2022).…”

Section: Effects Of Cirsium Setidens Extract On Gene Expression Relat...mentioning

confidence: 99%

Effects of Cirsium setidens extract on gene expression related to apoptosis induction and metastasis inhibition in human breast cancer

PARK

KIM

et al. 2023

Food Sci. Technol

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Cell apoptosis induction and metastasis suppression in human breast cancer cell, MDA-MB-231, were studied to assess the potential of Cirsium setidens extract (CSE) on breast cancer treatment. Cell viability and metastasis analysis using MDA-MB-231 confirmed CSE significantly inhibited the growth and proliferation of cancer cell without suppressing normal cell growth in the range of 0.25 to 0.5 mg/mL of CSE. To analyze the anticancer effect of CSE, the expressions of major genes related to in the apoptosis, including p53, AMPK-α, Bcl-2, and Bax were analyzed by reverse transcription-polymerase chain reaction. The expressions of AMPK-α, p53, and Bax increased by 45, 43, and 68%, respectively, while the expression of Bcl-2 decreased by 12%, showing that CSE treatment induced apoptosis of MDA-MB-231. The major compound of CSE was identified as rhoifolin, a type of flavone, through analysis using LC-MS/MS. Our findings confirmed that rhoifolin, known to possess a variety of significant biological activities, could be obtained from C. setidens and used as an effective natural compound to suppress breast cancer.

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Section: Effects Of Cirsium Setidens Extract On Gene Expression Relat...mentioning

confidence: 99%