2007
DOI: 10.1292/jvms.69.495
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Role of .BETA.1 Integrins in Adhesion of Canine Mastocytoma Cells to Extracellular Matrix Proteins

Abstract: ABSTRACT. The interactions of tumor cells with the extracellular matrix (ECM) are a crucial step in invasion and metastasis. Integrins are adhesive molecules forming heterodimers with α and β subunits that play a definitive role in these interactions. In this study, mastocytoma (mast cell tumor: MCT) cell-ECM interaction was investigated using 3 canine MCT cell lines: CM-MC (originating from cutaneous MCT), VI-MC (originating from intestinal MCT), and CoMS (originating from oral MCT). Flow cytometric analysis … Show more

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Cited by 3 publications
(2 citation statements)
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“…The mast cells adhered to the fibroblasts but did not grow. The main reports on the establishment of cell lines from canine MCTs in continuous culture and with no previous passage in mice are: HRMC 32 , CM-MC, VI-MC, CoMS 33 , 34 , MPT-1 35 , MPT-1.2 cells 36 and MPT-2 37 . However, in these studies, important characteristics were not described in detail, such as the number of passages with viable cells, the culture purification methods, culture conditions, and presence of fibroblasts or other cells in coculture.…”
Section: Discussionmentioning
confidence: 99%
“…The mast cells adhered to the fibroblasts but did not grow. The main reports on the establishment of cell lines from canine MCTs in continuous culture and with no previous passage in mice are: HRMC 32 , CM-MC, VI-MC, CoMS 33 , 34 , MPT-1 35 , MPT-1.2 cells 36 and MPT-2 37 . However, in these studies, important characteristics were not described in detail, such as the number of passages with viable cells, the culture purification methods, culture conditions, and presence of fibroblasts or other cells in coculture.…”
Section: Discussionmentioning
confidence: 99%
“…MCT cells bind collagen, fibronectin, and intercellular matrix laminin via extracellular matrix (ECM) β1 and α1-6 integrins [194]. In particular, VLA5 integrins are the activators of MCT [195].…”
Section: Integrinsmentioning
confidence: 99%