Role of Beta2 Agonists in Respiratory Medicine with Particular Attention to Novel Patents and Effects on Endocrine System and Immune Response

Larocca, N.E.; Moreno, Dolores; Garmendia, Jenny V.; Sanctis, Juan B. De

doi:10.2174/187221411797265908

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…Un grupo en Venezuela [59], con la finalidad de establecer las frecuencias genéticas de los polimorfismos Arg16Gly y Gln27Glu en un grupo de 105 asmáticos y 100 individuos sanos venezolanos. Demostró una diferencia significativa en la frecuencia Arg16Arg entre pacientes y controles:(28,6% vs 47%, p<0,01) respectivamente.…”

Section: Relación Entre Los Polimorfismos Del Gen Adrβ2 Y Asmaunclassified

“…Según los datos para los genotipos Arg16Gly y Gln27Glu, estos se asociaron con una mejor respuesta a uso del post broncodilatador. La conclusión que abordarón para este estudio,fue que, la frecuencia Arg16Arg en la población mestiza venezolana resultó más frecuente a lo descrito en otras poblaciones y esto puede ser un factor de protección en la aparición del asma [59].…”

Section: Relación Entre Los Polimorfismos Del Gen Adrβ2 Y Asmaunclassified

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Caracterización de los polimorfismos Arg16Gly16 y Gln27Glu del ?2-adrenoreceptor en adultos Colombianos y su asociación con el asma

Castillo¹

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Objetivo: Determinar si los polimorfismos del gen del receptor ?2-adrenergico (ADR?2), Arg16Gly y Gln27Glu se asocian con el asma en adultos que asisten al Hospital Universitario San Ignacio en la ciudad de Bogotá, Colombia. Materiales y métodos: Se caracterizaron 70 pacientes asmáticos y 59 no asmáticos para el aminoácido 16 y el 27 del ADR?2, mediante la reacción en cadena de polimerasa (PCR) e

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Section: Relación Entre Los Polimorfismos Del Gen Adrβ2 Y Asmaunclassified

Caracterización de los polimorfismos Arg16Gly16 y Gln27Glu del ?2-adrenoreceptor en adultos Colombianos y su asociación con el asma

Castillo¹

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Current Progress of Structural Studies on β<sub>2</sub> Adrenergic Receptor

唐¹

2015

HJMCe

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Beta-2 adrenergic receptor is an important member among G protein-coupled receptors superfamily. As a membrane protein, it is difficult to crystalize and its three-dimensional structure is not known until recent years. Thanks to the development of the crystal engineering techniques and the breakthroughs in the free electron X-ray laser crystallography, many crystal structures of β 2 adrenergic receptor at different states become available now. The discovery of the crystal structure β 2 adrenergic receptor has enriched our understanding on many life phenomena and its impact to the structure-based drug design cannot be overestimated. We review the discovery history of β 2 adrenergic receptor crystal structures, the structural characteristics of the receptor, the interactions between the receptor and different subtypes of the ligands (agonist, inverse agonist and antagonist) and clinical applications.

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Metabolic Syndrome and Asthma

Garmendia¹,

Moreno²,

García³

et al. 2014

EMI

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Metabolic syndrome (MetS) is a syndrome that involves at least three disorders dyslipidemia, insulin resistance, obesity and/or hypertension. MetS has been associated with several chronic diseases in the adulthood; however, in the recent years, the syndrome was redefined in children. Girls with early menarche and asthma, and children with MetS and asthma that reach adulthood appear to have higher risk to develop severe or difficult to control asthma and a higher probability to suffer cardiovascular diseases. It has been proposed that patients with MetS and endocrinological disorders should be considered a different entity in which pharmacologic treatment should be adjusted according to the individual. Recent patents on the field have addressed new issues on how endocrine control should be managed along with asthma therapeutics. In the near future, new approaches should decrease the high morbidity and mortality associated to these types of patients.

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Role of Beta2 Agonists in Respiratory Medicine with Particular Attention to Novel Patents and Effects on Endocrine System and Immune Response

Cited by 3 publications

References 42 publications

Caracterización de los polimorfismos Arg16Gly16 y Gln27Glu del ?2-adrenoreceptor en adultos Colombianos y su asociación con el asma

Caracterización de los polimorfismos Arg16Gly16 y Gln27Glu del ?2-adrenoreceptor en adultos Colombianos y su asociación con el asma

Current Progress of Structural Studies on β<sub>2</sub> Adrenergic Receptor

Metabolic Syndrome and Asthma

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