Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer

Zahra, Fatema Tuz; Sajib, Sanaullah; Mikelis, Constantinos M.

doi:10.3390/cancers13061422

Cited by 45 publications

(30 citation statements)

References 122 publications

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“…Since there is a strong connection between FGFs and angiogenesis [ 61 ], the reduction of FGFs levels is considered promising for inhibiting tumor development [ 62 , 63 ]. Among the FGFs, FGFb is one of the well-known pro-angiogenic factors [ 64 ], and in this study, we showed a significant reduction of FGFb levels after ApoE-Nut-PNPs + US stimulation. Although the literature reports that electric stimulation enhances angiogenesis in HUVECs by stimulating FGF2 secretion [ 65 ], our findings show as the FGFb levels decreased upon ApoE-Nut-PNPs + US administration.…”

Section: Discussionsupporting

confidence: 67%

Modulation of anti-angiogenic activity using ultrasound-activated nutlin-loaded piezoelectric nanovectors

Şen

Marino

Pucci

et al. 2022

Materials Today Bio

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Angiogenesis plays a fundamental role in tumor development, as it is crucial for tumor progression, metastasis development, and invasion. In this view, anti-angiogenic therapy has received considerable attention in several cancer types in order to inhibit tumor vascularization, and the progress of nanotechnology offers opportunities to target and release anti-angiogenic agents in specific diseased areas. In this work, we showed that the angiogenic behavior of human cerebral microvascular endothelial cells can be inhibited by using nutlin-3a-loaded ApoE-functionalized polymeric piezoelectric nanoparticles, which can remotely respond to ultrasound stimulation. The anti-angiogenic effect, derived from the use of chemotherapy and chronic piezoelectric stimulation, leads to disruption of tubular vessel formation, decreased cell migration and invasion, and inhibition of angiogenic growth factors in the presence of migratory cues released by the tumor cells. Overall, the proposed use of remotely activated piezoelectric nanoparticles could provide a promising approach to hinder tumor-induced angiogenesis.

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Section: Discussionsupporting

confidence: 67%

Modulation of anti-angiogenic activity using ultrasound-activated nutlin-loaded piezoelectric nanovectors

Şen

Marino

Pucci

et al. 2022

Materials Today Bio

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“…Despite the lack of direct reports on the pro-angiogenic effect of FGF in ocular tumors, it is reasonable to assume that its mere expression contributes to sustaining neo-vessel formation. Notably, anti-FGF approaches have been widely characterized as anti-angiogenic; furthermore, they can be employed to overcome resistance to conventional anti-VEGF therapies [ 91 , 92 ]. Interestingly, the anti-angiogenic effect exerted anti-FGFs/FGFRs should be considered from the perspective of an integrate approach, aimed at treating ocular tumors by acting on both the stromal and the parenchymal compartments.…”

Section: Discussionmentioning

confidence: 99%

Exploring the FGF/FGFR System in Ocular Tumors: New Insights and Perspectives

Loda

Turati

Semeraro

et al. 2022

IJMS

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Ocular tumors are a family of rare neoplasms that develop in the eye. Depending on the type of cancer, they mainly originate from cells localized within the retina, the uvea, or the vitreous. Even though current treatments (e.g., radiotherapy, transpupillary thermotherapy, cryotherapy, chemotherapy, local resection, or enucleation) achieve the control of the local tumor in the majority of treated cases, a significant percentage of patients develop metastatic disease. In recent years, new targeting therapies and immuno-therapeutic approaches have been evaluated. Nevertheless, the search for novel targets and players is eagerly required to prevent and control tumor growth and metastasis dissemination. The fibroblast growth factor (FGF)/FGF receptor (FGFR) system consists of a family of proteins involved in a variety of physiological and pathological processes, including cancer. Indeed, tumor and stroma activation of the FGF/FGFR system plays a relevant role in tumor growth, invasion, and resistance, as well as in angiogenesis and dissemination. To date, scattered pieces of literature report that FGFs and FGFRs are expressed by a significant subset of primary eye cancers, where they play relevant and pleiotropic roles. In this review, we provide an up-to-date description of the relevant roles played by the FGF/FGFR system in ocular tumors and speculate on its possible prognostic and therapeutic exploitation.

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“…Furthermore, curcumin may decrease the activity of FGF-induced neovascularization ( 183 ). Previous studies have revealed the angiogenic synergy between bFGF and VEGF pathway ( 184 – 186 ). bFGF may also increase the expression of pro-angiogenic factors, including VEGF, to regulate the angiogenic processes ( 187 , 188 ).…”

Section: Curcuminmentioning

confidence: 99%

Curcumin and Wnt/β‑catenin signaling in exudative age‑related macular degeneration (Review)

Vallée

2022

Int J Mol Med

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Curcumin is a natural product widely used due to its pharmacological effects. Nevertheless, only a limited number of studies concerning the effects of curcumin on exudative age-related macular degeneration (AMD) is currently available. Since ophthalmic diseases, including exudative AMD, have a marked impact on public health, the prevention and therapy of ophthalmic disorders remain of increasing concern. Exudative AMD is characterized by choroidal neovascularization (CNV) invading the subretinal space, ultimately enhancing exudation and hemorrhaging. The exudative AMD subtype corresponds to 10 to 15% of cases of macular degeneration; however, the occurrence of this subtype has been reported as the major cause of vision loss and blindness, with the occurrence of CNV being responsible for 80% of the cases with vision loss. In CNV increased expression of VEGF has been observed, stimulated by the overactivation of Wnt/β-catenin signaling pathway. The stimulation of the Wnt/β-catenin signaling pathway is responsible for the activation of several cellular mechanisms, simultaneously enhancing inflammation, oxidative stress and angiogenesis in numerous diseases, including ophthalmic disorders. Some studies have previously demonstrated the possible advantage of the use of curcumin for the inhibition of Wnt/β-catenin signaling. In the present review article, the different mechanisms of curcumin are described concerning its effects on oxidative stress, inflammation and angiogenesis in exudative AMD, by interacting with Wnt/β-catenin signaling.

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Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer

Cited by 45 publications

References 122 publications

Modulation of anti-angiogenic activity using ultrasound-activated nutlin-loaded piezoelectric nanovectors

Modulation of anti-angiogenic activity using ultrasound-activated nutlin-loaded piezoelectric nanovectors

Exploring the FGF/FGFR System in Ocular Tumors: New Insights and Perspectives

Curcumin and Wnt/β‑catenin signaling in exudative age‑related macular degeneration (Review)

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