“…Next, we confirmed that QUE suppressed IL-1b-induced senescence and the expression of SASP factors, such as MMP-3, MMP-13, IL6 and IL8. Similar to our results, other studies also showed that the protein levels of MMP-3 and MMP-13 could be suppressed by QUE in chondrocytes 30 ; several articles showed that QUE downregulated the production of IL-6 at different levels in hepatocytes, astrocytes and neurons 39 . Salminen et al demonstrated that the NF-kB pathway is a crucial regulator of the expression of SASP-related genes in senescent cells 25 .…”