The endocrine system contributes to the functioning of the body's metabolism, the increase or decrease in hormones favors the formation of disorders that develop metabolic diseases. Aim. Compile information on factors that intervene in the development of endocrinological diseases, mainly in hormonal action and alterations of certain metabolites. Methodology. A bib¬liographic search was carried out in Google Schoolar and PudMed using keywords, the information was analyzed in pairs. Results. Hormonal action is affected by desynchronization in hormonal production, triggering metabolic diseases. Measurement of calcium, phosphorus, PTH, 25OHD, 1.25OHD, calcitonin and osteocalcin help in the diagnosis. Conclusion. Circadian alterations favor the development of metabolic diseases, the participation of the clinical laboratory with specific tests is important.