Role of biologically important imidazole moiety on the antimicrobial and anticancer activity of Fe(III) and Mn(II) complexes

Engineered Fe3 triangle for the rapid and selective removal of aromatic cationic pollutants: complexity is not a necessity

“…The medium intensity bands 546 and 455 are due to the coordinate bond of Fe with various benzoate oxygen donors. 61 The new sharp band at 596 cm À1 can be due to the formation of iron and the m 3 -O atom. 62,63 These data are quite informative and further corroborate the single-crystal data.…”

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

“…The scientific literature reports a large diversity of species concerning both metal ions and ligands available for designing such effective anti-biofilm species ranging from simple to bulky ligands and acting as unidentate to multidentate species. A variety of complexes with anti-biofilm activity, ranging from species with known antibiotics or natural products to new synthetic ligands, mainly with low toxicity and chelating ability have been developed [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , <...>…”

“…A variety of complexes with anti-biofilm activity, ranging from species with known antibiotics or natural products to new synthetic ligands, mainly with low toxicity and chelating ability have been developed [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 ,…”

“…The most recent data concerning these aspects are presented in this review, with highlights on examples of complexes with antibiotics [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ], N-heterocycle derivatives [ 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 ], Schiff bases [ 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 ], biguanides [ 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , …”

“…The imidazole and its derivatives were also studied as ligands because of the ring presence in the protein structure as a part of histidine residues. Among these, [Mn(Him) 6 ]Cl 2 ·2H 2 O ( 11 ) (Him: imidazole) inhibits the E. coli biofilm [ 79 ] while [Cu 2 (acr) 4 (Hbzim/Me 2 bzim) 2 ] ( 12/13 ) (Hacr: acrylic acid, Hbzim: benzimidazole, Me 2 bzim: 5,6-dimethylbenzimidazole) exhibited anti-biofilm activity on a wide range of bacteria ( E. coli , S. aureus , B. subtilis , E. faecium ) as well as C. albicans , activity complemented for ( 12 ) by an antiproliferative effect on the colon adenocarcinoma (HT29) cell line [ 80 , 81 ].…”