Role of biologics in severe food allergy

Abstract

Purpose of review This review examine the dynamic landscape of food allergy treatment within the context of emerging biologics. Our purpose is to comprehensively evaluate the potential benefits, challenges, and transformative impact associated with the utilization of biologics in comparison to conventional therapeutic modalities. Recent findings This document synthesizes recent scientific investigations to various biologics, such as omalizumab, ligelizumab, dupilumab, and tezepelumab, providing a nuanced understanding of their roles in oral immunotherapy, rapid desensitization, and overall food allergy management. Recent studies and clinical trials highlight the impact of anti-IgE treatment on food allergies, revealing critical findings such as dose-related efficacy, facilitation of rapid desensitization in peanut allergies, and the sustained positive outcomes observed in individuals with multifood allergies. Summary The use of biologics presents a groundbreaking approach in the treatment of food allergies. The multifaceted action of these agents, along with their potential to overcome the challenges associated with traditional therapies, marks a significant advancement. Despite the persisting challenges of economic constraints and the need for further safety studies, biologics offer a promising avenue for improving the quality of life for individuals with food allergies. Ongoing research and collaborative efforts are imperative to fully realize the transformative potential inherent in these emerging therapeutic frontiers.

The Indirect Costs of Avoidance in Food Allergy Management: A Scoping Review

“…Likewise, as food insecurity [37][38][39] and health disparities [40,41] amongst those managing food allergy are now beginning to be recognised, exploration of these topics is warranted. Finally, as adult-onset allergies are increasingly prevalent [42], and various forms of immunotherapy [43] and biologics are becoming more commonly used for those with food allergy [44,45], these topics additionally need consideration, in relation to indirect costs, but also direct costs, and longitudinal changes of these costs types and their contributions to total costs.…”