Role of biomaterials in prevention of in‐stent restenosis

Laçin, Nelisa Türkoğlu; Utkan, Güldem

doi:10.1002/jbm.b.33083

Cited by 6 publications

(2 citation statements)

References 87 publications

(167 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Biodegradable stents have been successfully used in the treatment of coronary artery diseases [ 1 – 3 , 8 ] and esophageal strictures [ 6 , 9 – 11 ]. Biodegradable stents may also be utilized for urethral, tracheal, and other applications [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanical properties of a biodegradable self-expandable polydioxanone monofilament stent: In vitro force relaxation and its clinical relevance

et al. 2020

View full text Add to dashboard Cite

Biodegradable stents are promising treatments for many diseases, e.g., coronary artery disease, urethral diseases, tracheal diseases, and esophageal strictures. The mechanical properties of biodegradable stent materials play a key role in the safety and efficacy of treatment. In particular, insufficient creep resistance of the stent material could result in premature stent collapse or narrowing. Commercially available biodegradable self-expandable SX-ELLA stents made of polydioxanone monofilament were tested. A new, simple, and affordable method to measure the shear modulus of tiny viscoelastic wires is presented. The important mechanical parameters of the polydioxanone filament were obtained: the median Young's modulus wasẼ = 958 (922, 974) MPa and the shear modulus wasG = 357 (185, 387) MPa, resulting in a Poisson's ratio of ν = 0.34. The SX-ELLA stents exhibited significant force relaxation due to the stress relaxation of the polydioxanone monofilament, approximately 19% and 36% 10 min and 48 h after stent application, respectively. However, these results were expected, and the manufacturer and implanting clinician should be aware of the known behavior of these biodegradable materials. If possible, a biodegradable stent should be designed considering therapeutic force rather than initial force. Additionally, new and more advanced biodegradable shape-memory polymers should be considered for future study and use.

show abstract

Section: Introductionmentioning

confidence: 99%

Mechanical properties of a biodegradable self-expandable polydioxanone monofilament stent: In vitro force relaxation and its clinical relevance

et al. 2020

View full text Add to dashboard Cite

show abstract

“…An ideal coating should possess certain characteristics such as excellent binding ability, targeted and sustained release, and sufficient vector capacity for significant transfection. 56 Vectors for transfecting genes could be either viral vectors such as adenoviruses, 57 retroviruses, 58 or non-viral vectors such as liposomes and polymers. 59 Naked plasmids 60 are also transfected without vectors.…”

Section: Gene-eluting Stents (Ges)mentioning

confidence: 99%

Drug- and Gene-eluting Stents for Preventing Coronary Restenosis

et al. 2017

View full text Add to dashboard Cite

Coronary artery disease (CAD) has been reported to be a major cause of death worldwide. Current treatment methods include atherectomy, coronary angioplasty (as a percutaneous coronary intervention), and coronary artery bypass. Among them, the insertion of stents into the coronary artery is one of the commonly used methods for CAD, although the formation of in-stent restenosis (ISR) is a major drawback, demanding improvement in stent technology. Stents can be improved using the delivery of DNA, siRNA, and miRNA rather than anti-inflammatory/anti-thrombotic drugs. In particular, genes that could interfere with the development of plaque around infected regions are conjugated on the stent surface to inhibit neointimal formation. Despite their potential benefits, it is necessary to explore the various properties of gene-eluting stents. Furthermore, multifunctional electronic stents that can be used as a biosensor and deliver drug- or gene-based on physiological condition will be a very promising way to the successful treatment of ISR. In this review, we have discussed the molecular mechanism of restenosis, the use of drug- and gene-eluting stents, and the possible roles that these stents have in the prevention and treatment of coronary restenosis. Further, we have explained how multifunctional electronic stents could be used as a biosensor and deliver drugs based on physiological conditions.

show abstract

Fully Bioresorbable Vascular Stents

Malmonge,

Cliquet

2023

Current Trends in Biomedical Engineering

View full text Add to dashboard Cite

Role of biomaterials in prevention of in‐stent restenosis

Cited by 6 publications

References 87 publications

Mechanical properties of a biodegradable self-expandable polydioxanone monofilament stent: In vitro force relaxation and its clinical relevance

Mechanical properties of a biodegradable self-expandable polydioxanone monofilament stent: In vitro force relaxation and its clinical relevance

Drug- and Gene-eluting Stents for Preventing Coronary Restenosis

Fully Bioresorbable Vascular Stents

Contact Info

Product

Resources

About