Role of biometals in activation of immune cum inflammatory response in ovine ageing eye: a potential model for understanding human geriatric eye diseases

Nabi, Showkat Ul; Jan, A.; Muzamil, Showkeen; Razaq, R.; Muhee, Amatul; Ashraf, Tariq; Ahmad, Sheikh F.; Makhdoomi, D. M.; Shah, Naveed Nazir; Syed, Qutub

doi:10.1007/s10534-021-00331-y

Cited by 5 publications

(5 citation statements)

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“…In the present study, COVID-19 patients with hypercreatinemic were found to be in an older age group compared to the normocreatinemic sub-population. These findings are in accordance with a retrospective multicenter study, where patients with kidney dysfunction were in older age groups and were presented with severe manifestations of disease [ 42 , 43 , 44 ]. In the present study, most of the hypercreatinemic patients with COVID-19 were found to have hyper-inflammatory status and coagulopathies, as these patients were having elevated levels of LDH, ferritin, D-Dimer, procalcitonin, Hs-CRP, and IL-1 and IL-6 compared to hypercreatinemic patients with COVID-19.…”

Section: Discussionsupporting

confidence: 91%

Clinical Characterization and Outcomes of Patients with Hypercreatinemia Affected by COVID-19

et al. 2023

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The present study evaluated the clinical presentation and outcome of COVID-19 patients with underlying hypercreatinemia at the time of hospitalization. A retrospective observational study was conducted from the 23rd of March 2020 to the 15th of April 2021 in 1668 patients confirmed positive for COVID-19 in the Chest Disease Hospital in Srinagar, India. The results of the present study revealed that out of 1668 patients, 339 with hypercreatinemia had significantly higher rates of admission to the intensive care unit (ICU), severe manifestations of the disease, need for mechanical ventilation, and all-cause mortality. Multivariable analysis revealed that age, elevated creatinine concentrations, IL-1, D-Dimer, and Hs-Crp were independent risk factors for in-hospital mortality. After adjusted analysis, the association of creatinine levels remained strongly predictive of all-cause, in-hospital mortality (HR-5.34; CI-4.89–8.17; p ≤ 0.001). The amelioration of kidney function may be an effective method for achieving creatinemic targets and, henceforth, might be beneficial for improving outcomes in patients with COVID-19.

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Section: Discussionsupporting

confidence: 91%

Clinical Characterization and Outcomes of Patients with Hypercreatinemia Affected by COVID-19

et al. 2023

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“…Excessive generation of ROS leads to depletion of antioxidant enzymes Nabi et al (2021) therefore it may be proposed that injection of culprit drugs in penicillin-sensitive patients results in oxidative stress because of excessive generation of ROS and depletion of the antioxidant defense system. Radostits et al (2007) has earlier proposed the "reactive metabolite hypothesis" according to their study reactive oxidative species generated in adverse drug reactions activate the immune system in drug-induced hypersensitivity.…”

Section: Resultsmentioning

confidence: 99%

“…Erythrocyte lysate was prepared as per method Nabi et al (2021) oxidative stress markers were estimated in erythrocyte lysate. Lipid peroxidations (MDA), reduced glutathione (GSH), glutathione peroxidases (GPx) activity, glutathione reductase (GSSG) activity, Superoxide Dismutase (SOD) activity Xanthine oxidase (XO) and Catalase (CAT) activity in erythrocyte lysate were accessed as per the method of Jollow et al (1974), Marklund and Marklund (1974); Carlberg and Mannervik, (1975); Wright et al (1981), Mohandas et al (1984); Nabi et al 2021 andClaiborne, (1985) respectively. G6PD was estimated as per the method described by Beutler, (1984).…”

Section: Assessment Of Markers Of Oxidative Response and Glucose-6-ph...mentioning

confidence: 99%

Clinical Study on Penicillin Anaphylaxis and Role of Oxidative Stress and Pro-inflammatory Markers: An Implication for Therapy

Nabi

Haq

Muzammil

et al. 2022

IJAR

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Background: Penicillin belongs to the β-Lactam group of antibiotics which is used as a first-line drug in veterinary medicine. The occurrence of penicillin anaphylaxis and its pathophysiology is rarely reported in ruminants. Methods: In the present study, oxidative stress and pro-inflammatory response were investigated in 4 cases (Jersey crossbred) of penicillin hypersensitivity by assessing oxidative stress biomarkers and pro-inflammatory cytokines. Animals in the current experimental plan were divided into three groups, group I included penicillin hypersensitive (n=4), group II included penicillin tolerant (n=6) and group III (n=10), included healthy control animals. Result: Mean values of temperature, heart rate and respiration were significantly (p less than 0.05) elevated in the penicillin-sensitive group compared to the penicillin tolerant and control group. The present study revealed significantly (p less than 0.05) elevated levels of lipid peroxidation (MDA), xanthine oxidase (XO), nitric oxide (NO), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), while as levels of glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were significantly reduced in the penicillin-sensitive group. Levels of G6PD showed significant positive correlation with GPx (r=0.54, P less than 0.001) and catalase (r=0.34, P less than 0.05) while as significant negative correlation with XO (r=0.39, P less than 0.05) was observed. Collectively, these findings indicate that the pathophysiology of penicillin hypersensitivity involves anti-oxidant imbalance and enhanced pro-inflammatory response and targeting these pathways can have therapeutic implications for penicillin hypersensitivity.

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“…The anti-oxidant markers analyzed included superoxide dismutase (SOD), Catalase, lipid peroxidation (LPO), reduced glutathione peroxidase (GSH), Nitric oxide (NO), Vitamin C and glutathione peroxidase (GPx). The pro-inflammatory markers which include Interleukins (IL), IL-1, IL-2, IL-6 and TNF- α were estimated in granulation tissue of animal model as per method of [ 33 , 34 ].…”

Section: Methodsmentioning

confidence: 99%

Modulation of immune cum inflammatory pathway by earthworm granulation tissue extract in wound healing of diabetic rabbit model

M. E. Elkhalifa,

Ali,

Nabi

et al. 2024

Heliyon

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Role of biometals in activation of immune cum inflammatory response in ovine ageing eye: a potential model for understanding human geriatric eye diseases

Cited by 5 publications

References 60 publications

Clinical Characterization and Outcomes of Patients with Hypercreatinemia Affected by COVID-19

Clinical Characterization and Outcomes of Patients with Hypercreatinemia Affected by COVID-19

Clinical Study on Penicillin Anaphylaxis and Role of Oxidative Stress and Pro-inflammatory Markers: An Implication for Therapy

Modulation of immune cum inflammatory pathway by earthworm granulation tissue extract in wound healing of diabetic rabbit model

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Role of biometals in activation of immune cum inflammatory response in ovine ageing eye: a potential model for understanding human geriatric eye diseases

Cited by 5 publications

References 60 publications

Clinical Characterization and Outcomes of Patients with Hypercreatinemia Affected by COVID-19

Clinical Characterization and Outcomes of Patients with Hypercreatinemia Affected by COVID-19

​Clinical Study on Penicillin Anaphylaxis and Role of Oxidative Stress and Pro-inflammatory Markers: An Implication for Therapy

Modulation of immune cum inflammatory pathway by earthworm granulation tissue extract in wound healing of diabetic rabbit model

Contact Info

Product

Resources

About

Clinical Study on Penicillin Anaphylaxis and Role of Oxidative Stress and Pro-inflammatory Markers: An Implication for Therapy