Role of blood lipid metabolism in mechanisms of interrelationship of ischemic heart disease, anxious and depressive disorders

Abstract

Objective:To study interrelationships of indices of blood lipids with anxious and depressive disorders in IHD patients.Material and Methods:The investigation has included 85 patients with IHD (50,63±7,86 years). of Borderline States Department with anxious and depressive disorders of neurotic and affective level. Blood lipids: TCh, TG, Ch-LPHD have been identified with standardized methods. With calculation we assessed Ch-LPLD, Ch-LPVLD, and index of atherogeneity.Results:Two-factor disperse analysis has identified relationship between fraction of Ch-LPLD and depressive disorders (р=0,0083), and functional class (FC) of angina pectoris (р=0,0116). We have detected effects of interrelationship of depressive disorders, angina and level of Ch-LPLD (р=0,0072) in progressing angina against the background of a depressive episode or prolonged depressive reaction. 19 patients of FC II-III with anxious and depressive disorders were identified as having hypoalphacholesterolemia (Ch-LPHD<0,9 mmol/l; level of TG 2,44±0,5 mmol/l; level of Ch-LPLD 4,42±0,54 mmol/l, TCh 6,52±0,75 mmol/l, IA 4,5. Maximal low level of Ch-LPHD (0,74-0,82 mmol/l) has been revealed in 13 patients with IHD and anxiety disorders. In FC III and progressing angina in 23 patients with leading depressive syndrome level of TCh 7,48±0,55 mmol/l, Ch-LPLD 5,29±0,55 mmol/l, Ch-LPHD 1,04±0,13 mmol/l.In patients with IHD we have detected effects of interrelationship of neurotic and affective disorders, FC of angina and disturbances of metabolism of lipids. Anxious and depressive disorders were associated with atherogenic dyslipidemia conditioned by imbalance of Ch-LPLD and Ch-LPHD. The most substantial reduction of level of “antiatherogenic” fraction has been revealed in patients with IHD and phobic disorders.