Role of Bone Substitutes

Hollinger, Jeffrey O.; Brekke, John H.; Gruskin, Elliott; Lee, Dosuk

doi:10.1097/00003086-199603000-00008

Cited by 372 publications

(220 citation statements)

References 51 publications

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“…[10] In general, open porosity higher than 50 pct and interconnected pores with a mean diameter of 100 lm or higher are considered to be the minimum requirements to permit tissue ingrowth. [11,12] For example, Hadjicharalambous et al [13] showed that about 50 pct porosity and an average pore size of 150 lm are beneficial for cellular growth in zirconia ceramics. The important limitations to the use of materials, especially ceramics, with high porosity and pore size are their low mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic Deposition, Microstructure, and Corrosion Resistance of Porous Sol–Gel Glass/Polyetheretherketone Coatings on the Ti-13Nb-13Zr Alloy

Moskalewicz

Zych

Łukaszczyk

et al. 2017

Metall Mater Trans A

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In this study, microporous composite sol-gel glass/polyetheretherketone (SGG/PEEK) coatings were produced on the Ti-13Nb-13Zr titanium alloy by electrophoretic deposition. Coatings with different levels of high open porosity were developed by introducing SGG particles of varying diameters into the PEEK matrix. The microstructure of the coatings was characterized by electron microscopy and X-ray diffractometry. The coatings with 40-50 lm thickness were composed of semicrystalline SGG particles consisting of hydroxyapatite, CaSiO 3 , some Ca 2 SiO 4 , and an amorphous phase containing Ca, Si, P, and O, homogeneously embedded in a semicrystalline PEEK matrix. The size of SGG particles present in the coatings strongly influenced the formation of microcracks and their adhesion to the underlying substrate. Microscratch tests showed that the coating containing SGG particles with a diameter smaller than 45 lm and open porosity of 45 pct exhibited good adhesion to the titanium alloy substrate, much better than the coating containing particles with a diameter smaller than 85 lm and total open porosity equal to 48 pct. The corrosion resistance was investigated in Ringer's solution at a temperature of 310 K (37°C) for a pH equal to 7.4 and in deaerated solutions with the use of open-circuit potential, potentiodynamic polarization, and electrochemical impedance spectroscopy. The SGG/PEEK-coated alloy indicated better electrochemical corrosion resistance compared with the uncoated alloy.

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Section: Introductionmentioning

confidence: 99%

Electrophoretic Deposition, Microstructure, and Corrosion Resistance of Porous Sol–Gel Glass/Polyetheretherketone Coatings on the Ti-13Nb-13Zr Alloy

Moskalewicz

Zych

Łukaszczyk

et al. 2017

Metall Mater Trans A

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“…Currently, close to 1 million bone grafts are performed each year for the purpose of skeletal augmentation [3][4][5][6][7]. Autografts remain the clinical gold standard, driving bone repair by providing host cells, growth factors, and a template for bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…Some scaffolds (e.g., calcium phosphate) are characterized with a slow degradation [15], while others degrade too fast [16]. Polymeric scaffolds used for bone tissue engineering, such as poly(lactic-co-glycolic acid) or poly-Llactic acid, can induce inflammation due to the acidity of their hydrolysis products [6,17]. Moreover, matching mechanical properties of native bone remains an issue with most polyesters [7,18].…”

Section: Introductionmentioning

confidence: 99%

Silk based biomaterials to heal critical sized femur defects

Meinel

Betz

Fajardo

et al. 2006

Bone

221

179

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“…O osso, quando lesado, tem a capacidade de regenerar e retornar à estrutura tecidual original, sem a formação de tecido cicatricial (Hollinger et al, 1997;Remedios, 1999). Apesar desse potencial, a regeneração necessita de auxílio em várias ocasiões, como nas uniões retardadas, nas não-uniões, em fraturas múltiplas ou cominutivas, nas osteotomias, artrodeses e no preenchimento de cavidades ou defeitos segmentares extensos (Cook e Rueger, 1996).…”

Section: Introductionunclassified

“…Para manter ou auxiliar a capacidade regenerativa inerente, de forma relativamente inalterada, utilizam-se substitutos ósseos (Hollinger et al, 1997) osteoindutores e osteocondutores. Uma das vantagens desses substitutos ósseos é não produzir trauma adicional ao paciente, o que ocorre na coleta de enxerto autógeno.…”

Section: Introductionunclassified