Role of bovine herpesvirus 4 in bacterial bovine mastitis

Dóra, Kálmán; Jánosi, Szilárd; Erdei, László

doi:10.1016/j.micpath.2004.06.011

Cited by 13 publications

(8 citation statements)

References 16 publications

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“…A specific role for bovine herpes virus 4 ( BHV-4 ) in mastitis has been suggested (Wellenberg et al, 2002). Other authors state that BHV-4 does not play a role in causation of mastitis, but that reactivation of the virus by mastitis may contribute to more severe or prolonged mastitis episodes (Kálmán et al, 2004).…”

Section: Nonmastitis Pathogens and Udder Healthmentioning

confidence: 99%

Invited review: The role of contagious disease in udder health

Barkema

Green

Bradley

et al. 2009

Journal of Dairy Science

176

118

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Contagious diseases are a threat to animal health and productivity, both nationally and at the farm level. This makes implementation of biosecurity measures to prevent their introduction and spread within countries and farms a necessity. Mastitis is the most common and costly contagious disease affecting dairy farms in the western world. The major mastitis pathogens are endemic in most countries, and biosecurity measures to prevent introduction and transmission must therefore be implemented at farm level. The 40-yr-old mastitis control plan remains a solid foundation to prevent the spread of contagious intramammary infections. Contagious diseases that do not affect the mammary gland directly may have an indirect effect on mastitis. This is true for list A diseases such as foot and mouth disease, for which biosecurity measures may need to be taken at national level, and for other infections with nonmastitis pathogens such as bovine viral diarrhea virus and Mycobacterium avium ssp. paratuberculosis. Maintaining a closed herd decreases the risk of introduction of pathogens that affect udder health directly or indirectly. If animals are purchased, their udder health history should be evaluated and they should be examined and tested for contagious diseases. Transmission of infections by and to humans and nonbovine animals may occur. Contact with visitors and nonbovine animals should therefore be minimized. Because of globalization and heightened consumer awareness, the importance of biosecurity now supersedes individual farms, and increased pressure to control transmission of contagious diseases can be expected at industry or government levels in western countries and elsewhere.

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Section: Nonmastitis Pathogens and Udder Healthmentioning

confidence: 99%

Invited review: The role of contagious disease in udder health

Barkema

Green

Bradley

et al. 2009

Journal of Dairy Science

176

118

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“…As a gammaherpesvirus, it exhibits latency in monocyte/ macrophage lineage cells. This virus also plays a cofactor role in the escalation of clinical episodes and the extension of recovery periods in cases of postpartum metritis and mastitis caused by the primary bacterial agents such as Streptococcus uberis , Escherichia coli , Staphylococcus aureus , Streptococcus dysgalactiae , Streptococcus agalactiae , Trueperella pyogenes and viral agents such as BVDV and BoHV-1 ( 2 , 3 , 5 , 10 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

“…A microorganism-related inflammation of the mammary glands or quarters, mastitis is a major problem that negatively affects dairy cattle worldwide and has serious economic repercussions. The primary causes of mastitis are a wide range of bacterial species ( 2 ); however, it has been reported that foot and mouth disease virus, parainfluenza virus-3, BVDV, BoHV-1 and BoHV-4 have also been isolated from cases of natural clinical mastitis ( 7 , 19 , 20 , 28 ). If the suffering animal’s immunological activity is reduced or the virulence of the pathogenic microorganisms is high, a partially eliminated infection may persist for a longer time, often presenting as subclinical or chronic mastitis ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

Serum and milk levels of antibodies to bovine viral diarrhoea virus, bovine herpesvirus-1 and -4, and circulation of different bovine herpesvirus-4 genotypes in dairy cattle with clinical mastitis

Ataseven

Ambarcioğlu

Doğan

2023

Journal of Veterinary Research

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Introduction Bovine viral diarrhoea virus (BVDV) and bovine herpesvirus (BoHV)-1 and -4 are important causes of respiratory diseases and reproductive disorders of dairy cattle worldwide. Material and Methods Investigation of BVDV and BoHV-1 and -4 antibody levels in the serum and milk of dairy cattle in a group with clinical mastitis and a healthy group was undertaken using an indirect ELISA, and identification of the BoHV-4 genotypes in clinical mastitis cases was attempted by PCR and sequencing. Results Antibodies specific to BVDV, BoHV-1 and BoHV-4 were detected in the serum and milk of all dairy cattle with clinical mastitis. The cut-off values for BVDV and BoHV-1 in the sera and milk were extremely high in both healthy and mastitic animals. However, BoHV-4 antibodies were detected only in the clinically mastitic cattle, and BoHV-4 levels were higher in milk than in sera among these animals. Genotypes I and II of BoHV-4 were detected in the milk samples of four seropositive cows with clinical mastitis from the same herd. Conclusion The results of this investigation demonstrate that clinical mastitis cases in the same herd may have aetiology in different BoHV-4 genotypes.

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“…Currently, the exact role of this virus in cattle diseases is unknown. However, several research groups [ 8 – 11 ] are studying its participation in the infection of the genital tract. Most reports of BoHV-4 infection in different countries associate BoHV-4 with the development of post-partum and chronic metritis, either alone or in combination with other pathogens [ 12 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization of the First Bovine Herpesvirus 4 (BoHV-4) Strains Isolated from In Vitro Bovine Embryos production in Argentina

et al. 2015

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Bovine herpesvirus 4 (BoHV-4) is increasingly considered as responsible for various problems of the reproductive tract. The virus infects mainly blood mononuclear cells and displays specific tropism for vascular endothelia, reproductive and fetal tissues. Epidemiological studies suggest its impact on reproductive performance, and its presence in various sites in the reproductive tract highlights its potential transmission in transfer-stage embryos. This work describes the biological and genetic characterization of BoHV-4 strains isolated from an in vitro bovine embryo production system. BoHV-4 strains were isolated in 2011 and 2013 from granulosa cells and bovine oocytes from ovary batches collected at a local abattoir, used as “starting material” for in vitro production of bovine embryos. Compatible BoHV-4-CPE was observed in the co-culture of granulosa cells and oocytes with MDBK cells. The identity of the isolates was confirmed by PCR assays targeting three ORFs of the viral genome. The phylogenetic analyses of the strains suggest that they were evolutionary unlinked. Therefore it is possible that BoHV-4 ovary infections occurred regularly along the evolution of the virus, at least in Argentina, which can have implications in the systems of in vitro embryo production. Thus, although BoHV-4 does not appear to be a frequent risk factor for in vitro embryo production, data are still limited. This study reveals the potential of BoHV-4 transmission via embryo transfer. Moreover, the high variability among the BoHV-4 strains isolated from aborted cows in Argentina highlights the importance of further research on the role of this virus as an agent with the potential to cause reproductive disease in cattle. The genetic characterization of the isolated strains provides data to better understand the pathogenesis of BoHV-4 infections. Furthermore, it will lead to fundamental insights into the molecular aspects of the virus and the means by which these strains circulate in the herds.

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Role of bovine herpesvirus 4 in bacterial bovine mastitis

Cited by 13 publications

References 16 publications

Invited review: The role of contagious disease in udder health

Invited review: The role of contagious disease in udder health

Serum and milk levels of antibodies to bovine viral diarrhoea virus, bovine herpesvirus-1 and -4, and circulation of different bovine herpesvirus-4 genotypes in dairy cattle with clinical mastitis

Molecular Characterization of the First Bovine Herpesvirus 4 (BoHV-4) Strains Isolated from In Vitro Bovine Embryos production in Argentina

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