Role of bowel preparation on colocolonic anastomosis: experimental study in dogs

Abstract

0.05). CONCLUSION: Colocolonic anastomosis without previous bowel preparation was shown to be safe and efficacious, suggesting it is not an indispensable procedure in colorectal anastomosis surgery.]]>

Mechanical Bowel Preparation Does Not Affect Anastomosis Healing in an Experimental Rat Model

“…While anastomosis defects at postoperative day 9 were seen in 13% of dogs undergoing MBP, this rate was 47% in those not receiving MBP; the authors concluded that MBP could actually increase the rate of complications. In 2012, Regadas et al [ 11 ] reported a study of 42 dogs that were separated into 2 groups. The authors found no difference in anastomosis bursting pressure at postoperative day 21 between dogs undergoing MCT and those who did not.…”

“…While our study shows similarities to the study by Mersin et al [ 10 ], we also performed histopathological examination of anastomosis site tissues. The 3 studies previously mentioned in this paragraph [ 10 , 11 , 16 ] all examined anastomotic bursting pressure as a measure of anastomosis safety. Although O’Dwyer et al [ 18 ] found a significant decrease in anastomotic leakage pressure in animals not undergoing MBP, Regadus et al [ 11 ], Mersin et al [ 10 ], and the present study found no difference in bursting pressure between the groups.…”

“…While the literature reports that MBP leads to a decrease in anastomosis leakage, surgical site infections, hospital stay, and similar complications, some studies have reported no difference between patients who underwent MBP and those who did not [ 5 – 9 ]. There are also many animal studies supporting the use of MBP [ 10 , 11 ]. In the present study we evaluated the effect of MBP on colon anastomosis and surgical wound healing.…”

Fasting does not induce gastric emptying in rats

“…Preoperative (24 hours) fasting showed that was not sufficient for proper bowel preparation 21 , and many related substances might have better results, such as polyvinylpyrrolidone 22 and retrograde flushing 23 . The findings from this study suggest that fasting might be substituted by other techniques for gastrointestinal cleansing.…”

MECHANICAL AND MANUAL ANASTOMOSES IN COLORECTAL SURGERY (review)

“…Ряд хирургов считают её обязательной процедурой [64,76]. В то же время, немало сообщений, где не было обнаружено разницы в частоте несостоятельности анастомозов, инфекционных осложнений, сроках пребывания в стационаре между больными, получавшими механическую очистку кишечника и больным без подготовки [46][47][48]64,65], с другой стороны, существуют многочисленные публикации об эффективности механической очистки кишечника в эксперименте у животных [54,57,61]. Было изучено отношение к механическим анастомозам с помощью степлеров 241 хирургов-гастроэнтерологов в Японии [49].…”